Colorectal Cancer
The colon-rectal cancer (also known as Bowel Cancer) is the unrestrained enlargement of colon and rectal cells. Initially, this cancer develops at the walls of colon or rectal and at the later stage (i.e. metastasis) this extended to other organs through the blood or lymphatic vessels. There are numerous risk factors involved for the causation of this disease like high consumption of alcohol, fat, red meat, poor lifestyle like smoking, lack of physical exercises etc. Colorectal carcinoma is among the three most common malignancies reported worldwide with alarming numbers of incidence of 1234000 cases and 608000 fatalities worldwide. The highest rate of incidence in both the sexes was reported from Australian continent followed by Western Europe and North America. However, much rise in incidence of colon and rectal cancer has been observed in Indian subcontinent due to changing food habits, environmental conditions and lifestyle.
Colorectal Cancer Gene Database
Despite imperative advances in surgical techniques and adjuvant therapies in oncology, molecular diagnostic tools for colorectal carcinoma are still not very well established. Though, much of work is being carried out to understand the mechanism of carcinogenesis and advancement of this disease. There is an urgent need to find better diagnostic tools for colorectal carcinogenesis in early stages. The present effort involved construction of highly curated factual database named Colon Rectal Cancer Gene Database (CoReCG), which contains all relevant validated colon-rectal cancer genes information from published literature with an effective knowledge based information retrieval system. Therefore CoReCG provides the information of mechanism of incidence and progression of the disease, which would help the researchers to look for colon-rectal specific gene therapies and disease specific targeted drug designing. Moreover, it will help in development of biomarkers for the better and early detection of CRC and will help in better clinical management of the disease.