CoReCG

Team

Dr. Ashutosh Singh Assistant Professor School of Natural Sciences Department of Life Sciences Shiv Nadar University Uttar Pradesh, India Email: [email protected] [email protected]	Dr. Dhwani Raghav Research Scientist 1 Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, Delhi, India Email: [email protected]
Dr. Sri Krishna Jayadev Assistant Professor School of Natural Sciences Department of Life Sciences Shiv Nadar University Uttar Pradesh, India Email: [email protected]	Er. Rahul Agarwal Ph.D Scholar School of Natural Sciences Department of Life Sciences Shiv Nadar University Uttar Pradesh, India Email: [email protected]
Binayak Kumar Ph.D Scholar School of Natural Sciences Department of Life Sciences Shiv Nadar University Uttar Pradesh, India Email: [email protected]

Highlights

N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients(British Joumal of Cancer.

The role of annexin A3 playing in cancers

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.

Comprehensive molecular characterization of human colon and rectal cancer.

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma.

Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.

Recurrent R-spondin fusions in colon cancer.

A proteomics analysis of cell signaling alterations in colorectal cancer.

Loss of Expression of the Tumor Suppressor CEACAM1 Links Different Hereditary Colorectal Carcinoma Subtypes to the Genesis of Sporadic Colorectal Carcinoma.

Evaluation of Germline BMP4 Mutation as a Cause of Colorectal Cancer.

Promoter hypermethylation downregulates RUNX3 gene expressionin colorectal cancer cell lines.

CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer.

Screening of tumor suppressor genes on 1q31.1-32.1 in Chinese patients with sporadic colorectal cancer.

Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

Downregulation of EphA7 by hypermethylation in colorectal cancer

Significance of ELF3 mRNA Expression for Detection of Lymph Node Metastases of Colorectal Cancer

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms

Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.

Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas

Human leukocyte antigen G expression as a significant prognostic indicator for patients with colorectal cancer.

Analysis of the Association between CIMP and BRAFV600E in Colorectal Cancer by DNA Methylation Profiling.

HEDGEHOG SIGNALLING IN COLORECTAL TUMOUR CELLS: INDUCTION OF APOPTOSIS WITH CYCLOPAMINE TREATMENT.

Selective suppression of cytokine secretion in whole blood cell cultures of patients with colorectal cancer.

Receptors for Interleukin (IL)-4 Do Not Associate with the Commong Chain, and IL-4 Induces the Phosphorylation of JAK2 TyrosineKinase in Human Colon Carcinoma Cells.

Comparative proteomic analysis for the insoluble fractions of colorectal cancer patients.

Smad2 and Smad3 Phosphorylated at Both Linker and COOHTerminal Regions Transmit Malignant TGF-B Signal in Later Stages ofHuman Colorectal Cancer and Somatic alterations of the SMIAD-2 gene in human colorectal cancers.

Smad7 induces hepatic metastasis in colorectal cancer.

Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review

Methylation of the Polycomb Group Target Genes (PCGT) is a Possible Biomarker for Favorable Prognosis in Colorectal Cancer.

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

Methylation of NEUROG1 in Serum Is a Sensitive Marker for the Detection of Early Colorectal cancer.

Notch1 counteracts WNT/?-catenin signalingthrough chromatin modification in colorectal cancer.

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

RET is a potential tumor suppressor gene in colorectal cancer.

Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair.

Down-Regulation of CDH1 Is Associated with Expression of SNAI1 in Colorectal Adenomas.

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-20deoxycytidine to increase SPARC expression and improve therapy response.

The Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells.

MicroRNA Profiling Differentiates Colorectal Cancer According to KRAS Status.

Tissue inhibitor of metalloproteinases-3 transfer suppresses malignant behaviors of colorectal cancer cells.

TUFM is a potential new prognostic indicator for colorectal carcinoma.

VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal patients.

IFN?-dependent, spontaneous development of colorectal carcinomas in SOCS1-defi cient mice

Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer.

Colon Cancer Stem Cells Resist Antiangiogenesis Therapy-induced Apoptosis

N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients(British Joumal of Cancer.

The role of annexin A3 playing in cancers

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer.

Comprehensive molecular characterization of human colon and rectal cancer.

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma.

Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.

Recurrent R-spondin fusions in colon cancer.

A proteomics analysis of cell signaling alterations in colorectal cancer.

Loss of Expression of the Tumor Suppressor CEACAM1 Links Different Hereditary Colorectal Carcinoma Subtypes to the Genesis of Sporadic Colorectal Carcinoma.

Evaluation of Germline BMP4 Mutation as a Cause of Colorectal Cancer.

Promoter hypermethylation downregulates RUNX3 gene expressionin colorectal cancer cell lines.

CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer.

Screening of tumor suppressor genes on 1q31.1-32.1 in Chinese patients with sporadic colorectal cancer.

Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

Downregulation of EphA7 by hypermethylation in colorectal cancer

Significance of ELF3 mRNA Expression for Detection of Lymph Node Metastases of Colorectal Cancer

Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms

Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.

Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer

Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas

Human leukocyte antigen G expression as a significant prognostic indicator for patients with colorectal cancer.

Analysis of the Association between CIMP and BRAFV600E in Colorectal Cancer by DNA Methylation Profiling.

HEDGEHOG SIGNALLING IN COLORECTAL TUMOUR CELLS: INDUCTION OF APOPTOSIS WITH CYCLOPAMINE TREATMENT.

Selective suppression of cytokine secretion in whole blood cell cultures of patients with colorectal cancer.

Receptors for Interleukin (IL)-4 Do Not Associate with the Commong Chain, and IL-4 Induces the Phosphorylation of JAK2 TyrosineKinase in Human Colon Carcinoma Cells.

Comparative proteomic analysis for the insoluble fractions of colorectal cancer patients.

Smad2 and Smad3 Phosphorylated at Both Linker and COOHTerminal Regions Transmit Malignant TGF-B Signal in Later Stages ofHuman Colorectal Cancer and Somatic alterations of the SMIAD-2 gene in human colorectal cancers.

Smad7 induces hepatic metastasis in colorectal cancer.

Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review

Methylation of the Polycomb Group Target Genes (PCGT) is a Possible Biomarker for Favorable Prognosis in Colorectal Cancer.

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.

Methylation of NEUROG1 in Serum Is a Sensitive Marker for the Detection of Early Colorectal cancer.

Notch1 counteracts WNT/?-catenin signalingthrough chromatin modification in colorectal cancer.

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

RET is a potential tumor suppressor gene in colorectal cancer.

Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair.

Down-Regulation of CDH1 Is Associated with Expression of SNAI1 in Colorectal Adenomas.

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-20deoxycytidine to increase SPARC expression and improve therapy response.

The Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells.

MicroRNA Profiling Differentiates Colorectal Cancer According to KRAS Status.

Tissue inhibitor of metalloproteinases-3 transfer suppresses malignant behaviors of colorectal cancer cells.

TUFM is a potential new prognostic indicator for colorectal carcinoma.

VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal patients.

IFN?-dependent, spontaneous development of colorectal carcinomas in SOCS1-defi cient mice

Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer.

Colon Cancer Stem Cells Resist Antiangiogenesis Therapy-induced Apoptosis

Statistics

Gene Entries	2056
Pubmed Entries	2486
PTMs	2175
Pathways	288
Domains	11815

Links

NCBI	HGNC
UNIPROT	ENSEMBL
UCSC	dbSNP
PDB	KEGG
STRING	COSMIC
HPRD	OMIM