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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ALYREF 10189 THO complex 4  17ALY; BEF; REF; THOC4; ALY/REF 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : TNM Stage II

Biochemical isolation to nano-LC-MS/MS analysisUnknown--


Gene Details



Chromosome: 17; NC_000017.10 (79845711..79849462, complement)

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Gene Type protein coding
Gene Family THO complex subunits, RNA binding motif (RRM) containing
Description The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q25.3
Start 81887835  
End 81891622  
Strand +  
Gene Sequence

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Length 3788  
OMIM ID 604171   
HGNC ID HGNC:19071   
Unigene ID Hs.534385    
Ensembl ID ENSG00000183684   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005782.3
Exon join(37..300,803..934,2294..2441,3040..3103,3205..3382, 3478..3788)  
mRNA Sequence

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Length 1113  



CDS Information


   
Locationjoin(43..300,803..934,2294..2441,3040..3103,3205..3382, 3478..3492)
CDS Sequence

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CCDS ID CCDS32768.2



Protein Information


      
Protein IDNP_005773.3
Protein NameTHO complex 4
Molecular Wt. (Da)27427
Protein Sequence

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Length 264  
Uniprot IDP07099
Ensembl Protein ID ENSP00000272167  



Post-translational Modification Information (Source : HPRD)


Residue Type site
RMethylation57
RMethylation211
RMethylation211
SPhosphorylation190;-
SPhosphorylation15
SPhosphorylation246
SPhosphorylation101

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4116MAGOH4005NP_002361.1in vitro11707413   
7919BAT1805NP_004631.1yeast 2-hybrid14667819   
51176LEF11075NP_057353.1in vitro9119228   


Pathway Information


                        
Pathway Name Pathway ID
Herpes simplex infection hsa05168
mRNA surveillance pathway hsa03015
RNA transport hsa03013
Spliceosome hsa03040


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12680107-180  RRM_THOC4
cl17169107-180  RRM_SF superfamily
cd12418107-180  RRM_Aly_REF_like
cd00590108-179  RRM_SF
cd12681107-180  RRM_SKAR
cd12399107-178  RRM_HP0827_like
pfam00076108-176  RRM_1
cd12382107-179  RRM_RBMX_like
cd12414107-175  RRM2_RBM28_like
cd12267107-181  RRM_YRA1_MLO3
cd12447107-180  RRM1_gar2
cd12450108-183  RRM1_NUCLs
cd12413108-180  RRM1_RBM28_like
cd12392107-174  RRM2_SART3
cd12316107-174  RRM3_RBM19_RRM2_MRD1
cd12387108-178  RRM3_hnRNPM_like
cd12298107-180  RRM3_Prp24
cd12284108-178  RRM2_RBM23_RBM39
cd12415108-180  RRM3_RBM28_like
cd12378108-178  RRM1_I_PABPs
cd12449107-174  RRM_CIRBP_RBM3
cd12660108-180  RRM2_MYEF2
cd12386110-180  RRM2_hnRNPM_like
cd12384107-180  RRM_RBM24_RBM38_like
cd12381107-189  RRM4_I_PABPs
cd12363115-175  RRM_TRA2
cd12642110-178  RRM_TRA2A
cd12318108-180  RRM5_RBM19_like
pfam13893122-180  RRM_5
cd12365108-179  RRM_RNPS1
cd12408110-168  RRM_eIF3G_like
cd12361107-179  RRM1_2_CELF1-6_like
cd12592108-179  RRM_RBM7
cd12380110-176  RRM3_I_PABPs
cd12251108-180  RRM3_hnRNPR_like
cd12343107-179  RRM1_2_CoAA_like
cd12393110-174  RRM_ZCRB1
cd12659108-180  RRM2_hnRNPM
cd12619108-178  RRM2_PUB1
cd12336108-179  RRM_RBM7_like
cd12498108-180  RRM3_ACF
cd12333108-165  RRM2_p54nrb_like
cd12570107-179  RRM5_MRD1
cd12398110-178  RRM_CSTF2_RNA15_like
cd12566107-178  RRM2_MRD1
cd12324108-175  RRM_RBM8
cd12391110-176  RRM1_SART3
cd12320107-179  RRM6_RBM19_RRM5_MRD1
cd12641108-178  RRM_TRA2B
cd12674108-174  RRM1_Nop4p
cd12409110-180  RRM1_RRT5
cd12407107-182  RRM_FOX1_like
cd12593108-179  RRM_RBM11
cd12254108-175  RRM_hnRNPH_ESRPs_RBM12_like
cd12412107-178  RRM_DAZL_BOULE
cd12236108-174  RRM_snRNP70
cd12353108-178  RRM2_TIA1_like
cd12283109-179  RRM1_RBM39_like
cd12389108-174  RRM2_RAVER
cd12240108-178  RRM_NCBP2
cd12675107-184  RRM2_Nop4p
cd12609107-180  RRM2_CoAA
cd12242107-179  RRM_SLIRP
cd12564107-168  RRM1_RBM19
cd12345108-182  RRM2_SECp43_like
cd12636107-164  RRM2_Bruno_like
cd12494108-180  RRM3_hnRNPR
cd12448108-178  RRM2_gar2
cd12404108-178  RRM2_NCL
cd12506113-165  RRM3_hnRNPH_CRSF1_like
cd12650108-171  RRM1_Hu
cd12241108-174  RRM_SF3B14
cd12673107-178  RRM_BOULE
cd12733110-163  RRM3_GRSF1
cd12317108-171  RRM4_RBM19_RRM3_MRD1
cd12271110-179  RRM1_PHIP1
cd12235108-174  RRM_PPIL4
cd12589108-165  RRM2_PSP1
cd12376108-180  RRM2_Hu_like
cd12773108-183  RRM2_HuR
cd12311108-179  RRM_SRSF2_SRSF8
cd12372108-180  RRM_CFIm68_CFIm59
cd12590108-165  RRM2_PSF
cd12355107-174  RRM_RBM18
cd12438123-183  RRM_CNOT4
cd12591108-163  RRM2_p54nrb
cd12379110-174  RRM2_I_PABPs
cd12651108-180  RRM2_SXL
cd12524108-179  RRM1_MEI2_like
cd12567107-178  RRM3_RBM19
cd12304115-180  RRM_Set1
cd12454110-180  RRM2_RIM4_like
cd12579107-162  RRM2_hnRNPA0
cd12375108-168  RRM1_Hu_like
cd12223108-178  RRM_SR140
cd12662107-180  RRM3_MYEF2
cd12405108-180  RRM3_NCL
cd12306110-178  RRM_II_PABPs
cd12278122-172  RRM_eIF3B
cd12273108-179  RRM1_NEFsp
cd12671110-178  RRM_CSTF2_CSTF2T
cd12370107-174  RRM1_PUF60
cd12571107-164  RRM6_RBM19
cd12346108-179  RRM3_NGR1_NAM8_like
cd12397108-171  RRM2_Nop13p_fungi
cd12239107-179  RRM2_RBM40_like
cd12635107-168  RRM2_CELF3_4_5_6
cd12366116-175  RRM1_RBM45
cd12395110-179  RRM2_RBM34
cd12390108-178  RRM3_RAVER
cd12676108-165  RRM3_Nop4p
cd12608107-180  RRM1_CoAA
cd12652108-173  RRM2_Hu
cd12400108-179  RRM_Nop6
cd12334108-176  RRM1_SF3B4
cd12354110-176  RRM3_TIA1_like
cd12321107-184  RRM1_TDP43
cd12672108-165  RRM_DAZL
cd12495108-184  RRM3_hnRNPQ
cd12359107-173  RRM2_VICKZ
cd12607107-179  RRM2_RBM4
cd12362108-179  RRM3_CELF1-6
cd12618108-182  RRM2_TIA1
cd12280110-180  RRM_FET
cd12295107-180  RRM_YRA2
cd12246108-179  RRM1_U1A_like
cd12569108-171  RRM4_RBM19
cd12312108-179  RRM_SRSF10_SRSF12
cd12383107-175  RRM_RBM42
cd12496108-180  RRM3_RBM46
cd12330107-179  RRM2_Hrp1p
cd12658107-179  RRM1_MYEF2
cd12340107-176  RBD_RRM1_NPL3
cd12534110-180  RRM_SARFH
cd12735113-165  RRM3_hnRNPH3
cd12352108-178  RRM1_TIA1_like
cd12226108-180  RRM_NOL8
cd12315107-179  RRM1_RBM19_MRD1
cd12276108-179  RRM2_MEI2_EAR1_like
cd12637107-169  RRM2_FCA
cd12515108-174  RRM5_RBM12_like
cd12497108-180  RRM3_RBM47
cd12774108-180  RRM2_HuD
cd12776108-168  RRM2_HuC
cd12338107-180  RRM1_SRSF1_like
cd12661107-180  RRM3_hnRNPM
cd12373107-180  RRM_SRSF3_like
cd12612108-183  RRM2_SECp43
cd12617108-182  RRM2_TIAR
cd12568108-164  RRM3_MRD1
cd12565107-168  RRM1_MRD1
cd12588107-180  RRM1_p54nrb
cd12385110-179  RRM1_hnRNPM_like
cd12416107-175  RRM4_RBM28_like
smart00360107-178  RRM
pfam14259108-175  RRM_6
COG0724107-203  RRM
TIGR01628108-190  PABP-1234
TIGR01628108-189  PABP-1234
TIGR01628108-190  PABP-1234
TIGR01622107-181  SF-CC1
TIGR01628110-174  PABP-1234
PLN03134107-209  PLN03134
TIGR01648108-180  hnRNP-R-Q
TIGR01661108-171  ELAV_HUD_SF
TIGR01645107-197  half-pint
TIGR01622108-199  SF-CC1


Ontology Information


   
HPRD ID1281
Molecular ClassUnknown
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO