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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NAT1 | 9 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 8 | AAC1; MNAT; NATI; NAT-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9528834 | 1998 | Cell line : HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | DNA Sequencing | Polymorhpism | - | DNA sequencing revealed the wild-type sequence (NAT1*4) and two single base substitutions at adjacent positions 999 bp (C to T, NAT1*14) and 1000 bp (G to A, NAT1*15) of the gene, changing Arg187 to a stop codon and Arg187 to Gln respectively. NAT1 alleles NAT1*4 (0.98) and NAT1*15 (0.02) were present at a similar frequency colorectal cancer and control.The third allele, NAT1*14, was present only in the colorectal cancer group at a frequency of 0.006. |
| 22327651 | 2012 | Cell line : - Source : Edinburgh Royal Infirmary, Edinburgh, UK; Western General Hospital, Edinburgh, UK; St Johns Hospital, Livingstone, UK. Sample Type : CRC tumor and Normal tissue No. of Sample : 260 CRC tumor and 323 Normal tissue Stage : - | Meta-analysis | Polymorhpism | - | Meta-analysis wasn't able to detect a significant association between polymorphisms in NAT1 and predisposition to CRC. However, CRC is a multifactor and multiprocessing disease that resulted from complex interactions between gene and gene environment. 20 published literatures that described the association between the NAT1 polymorphisms and CRC. |
| 22724046 | 2012 | Cell line : - Source : Literature survey Sample Type : - No. of Sample : - Stage : - | Genotyping | Polymorhpism | - | Polymorphisms in NAT1, NAT2, and GSTA1 are related to colorectal adenoma risk in German cohort. Gentyping were performed by Sequenom MassArray system and the LightCycler 480. |
| 22905173 | 2012 | Cell line : - Source : EPIC-Heidelberg cohort Sample Type : Population based case control study No. of Sample : 488 CRC tumor and 828 normal tissue Stage : - | Meta-analysis | Polymorhpism | - | Individuals with the rapid NAT2 genotype have higher risk of CRC. |
| 21347396 | 2011 | Cell line : - Source : Medline database Sample Type : Population based case control study No. of Sample : 11,724 CRC cases and 16,215 controls and 3,701 CRA cases and 5,149 controls Stage : - | real time RT- PCR, Western Blottting | Unknown | - | NAT1 may be a novel drug target for cancer therapeutics. This study indentified that a phenotypic change in cancer cells such as an increase in cell-cell contact growth inhibition and a loss of cell viability at confluence. associated with the loss of NAT1 protein. NAT1 may play a role in cell growth and survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| Chromosome | 8 |
| Location | 8p22 |
| Start | 18170462 |
| End | 18223689 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 53228 |
| OMIM ID | 108345 |
| HGNC ID | HGNC:7645 |
| Unigene ID | Hs.591847 |
| Ensembl ID | ENSG00000171428 |
| PharmGKB ID | PA17 |
mRNA Information
| mRNA ID | NM_001291962.1 |
|---|---|
| Exon | join(1..46,218..278,39320..39494,46416..46533, 48950..49028,51581..53228) | mRNA Sequence | Download Select all |
| Length | 2025 |
CDS Information
| Location | join(46433..46533,48950..49028,51581..52459) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS55205.1 |
Protein Information
| Protein ID | NP_001153647.1 |
|---|---|
| Protein Name | N-acetyltransferase 1 (arylamine N-acetyltransferase) |
| Molecular Wt. (Da) | 40715 |
| Protein Sequence | Download Select all |
| Length | 352 |
| Uniprot ID | P18440 |
| Ensembl Protein ID | ENSP00000307218 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Acetylation | 68 |
| T | Phosphorylation | 25 |
Enzyme Information
| EC | 2.3.1.5 |
|---|---|
| Name | arylamine N-acetyltransferase arylamine acetylase beta-naphthylamine N-acetyltransferase 4-aminobiphenyl N-acetyltransferase acetyl CoA-arylamine N-acetyltransferase 2-naphthylamine N-acetyltransferase arylamine acetyltransferase indoleamine N-acetyltransferase N-acetyltransferase (ambiguous) p-aminosalicylate N-acetyltransferase serotonin acetyltransferase serotonin N-acetyltransferase |
| Class | Transferases; Acyltransferases; Transferring groups other than aminoacyl groups |
| Sysname | acetyl-CoA:arylamine N-acetyltransferase |
| Substrate | acetyl-CoA [CPD:C00024]; arylamine |
| Product | CoA [CPD:C00010]; N-acetylarylamine |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Caffeine metabolism | hsa00232 |
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - other enzymes | hsa00983 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00797 | 20-280 | Acetyltransf_2 |
| cl00949 | 20-280 | Acetyltransf_2 superfamily |
| COG2162 | 1-275 | NhoA |
| PRK15047 | 3-284 | PRK15047 |
Ontology Information
| HPRD ID | 149 |
|---|---|
| Molecular Class | Enzyme: Acyltransferase |
| Molecular Function | Acyltransferase activity (GO:0008415) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P18440 | DB01015 | Sulfamethoxazole | SmallMoleculeDrug |