CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
NAT2	10	N-acetyltransferase 2 (arylamine N-acetyltransferase)	8	AAC2; PNAT; NAT-2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
9528834	1998	Cell line : - Source : Edinburgh Royal Infirmary, Edinburgh, UK; Western General Hospital, Edinburgh, UK; St Johns Hospital, Livingstone, UK. Sample Type : CRC tumor and Normal tissue No. of Sample : 245 CRC tumor and 217 normal tissue Stage : Duke stage A-C	DNA Sequencing	Polymorhpism	-	May be there is a genetic linkage between NAT1 and NAT2 which are closely related and have overlapping substrate specificity.
21188325	2010	Cell line : - Source : 3rd Surgical Clinic of Cluj-Napoca Sample Type : CRC tumor and Normal tissue No. of Sample : 70 Stage : Duke stage B-D	PCR based DNA Fragment Sequencing	Polymorhpism	-	NAT2 gene may be considered as a prognostic factor for the survival of patients with CRC. Compared patients with a slow acetylator genotype with those having an intermediate or rapid acetylator genotype.
21390146	2011	Cell line : - Source : Oncology Division, Department of Gastroenterology, University Hospital, UNIFESP. Sample Type : CRC tumor and Normal tissue No. of Sample : 147 CRC tumor and 212 normal tissue Stage : -	PCR- RFLP	Polymorhpism	-	The risk of CRC was higher among fast acetylators who reported a higher meat intake. Slow NAT2 acetylation was associated with an increased risk of CRC.
22588343	2012	Cell line : - Source : Pubmed, EMBASE, Medline, Biosis, Wiley-Blackwell, ISI Web of Knowledge, CNKI, and Chinese Biomedicine Database Sample Type : Population based case control study No. of Sample : 8 phenotype studies (791 cases and 1158 controls) and 45 genotype studies (13 875 cases and 18 879 controls) Stage : -	Meta-analysis	Polymorhpism	-	Relevant studies that had investigated NAT2 polymorphism and CRC susceptibility. Results of meta-analysis suggest that there is no overall association between NAT2 polymorphism and CRC susceptibility.
22724046	2012	Cell line : - Source : EPIC-Heidelberg cohort. Sample Type : - No. of Sample : - Stage : -	Genotyping	Polymorhpism	-	Polymorphisms in NAT1, NAT2, and GSTA1 are related to colorectal adenoma risk in German cohort.
22905173	2012	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Meta-analysis	Polymorhpism	-	-
23226745	2012	Cell line : - Source : - Sample Type : Population based case control study No. of Sample : 7 case-control studies, including 3,197 cases and 4,681 controls Stage : -	Meta-analysis	Polymorhpism	-	NAT2 polymorphisms may be a risk factor for colorectal adenomas in individuals who have a history of smoking.

Gene Details

Chromosome: 8; NC_000008.10 (18248755..18258723)
View Larger Image

Gene Type	protein coding
Gene Family	-
Description	This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Chromosome	8
Location	8p22
Start	18391245
End	18401219
Strand	+
Gene Sequence	>gi\|568815590:18391245-18401219 Homo sapiens chromosome 8, GRCh38.p2 Primary Assembly TGAGATCACTTCCCTTGCAGACTTTGGAAGGGAGAGCACTTTATTACAGACCTTGGAAGCAAGAGGATTG CATTCAGCCTAGTTCCTGGTTGCTGGCCAAAGTAAGTAGAACTTTGTAAGTAATTTGCAGTGTACTTTGA AAGTGGGGTATAAATTAAAAATAAAATCAAGTCCCCCTACTGACTGAATGGATCCCCTCTTGTCCTAGGC GACCCCAGAGAAACCTGGAAAACTAAATTCCAGGCCATAATGGAAAGGGAGGTCAGACACGCCTCATTAT ACACACTCCCTTTTGGAGTTCAGGCACAACTGACCAGCATTAACATTGAAACAGTGATCATAAGACTGTC AAAATGGACTGTTTGTGGGAATAAGATACCAAATTCCAATCTGACTCTGGTTTAGCATCACATGACAATA GCAGACCCTGAAGGAAATCAATATATTTAATCCCCAAAATATATTTCTTTGACACATATTGAAATGGTCT TGCAAAACCATCTTTTATGGGGAAATTTGCTGGTTTCTGGCTCTGCTCTGATTGAGGAGAGAATAAATGA GAGTCTGACACCTTAAAAATCTGAAAAGAGATATTTACCATCTGTTTTCTCTAAGGCTGCTAGCTGGAGG TTTCATCTACATGACATAAACCATGGTTCCCATAAGCCCTTTTAACTCAAGCATTTAATTGTACTGACCG CAAGTCTTTAGACAAAACTTAACTCTTCAACAAATTGCCAATCACAAAATCTTTGAATCCACCTTTGTCC TGTAAGCTCTCCTACTTCAATATGTCTGATTTTCAGGCAGAGCCAATGTATACCTTATGTGGGGGCCATA GGCTGTTGGCCCCCTAAAGCTTCACTAAAAGTCACTGTCATGTGACAGGTTGATTAATAGGGGAAAGGGA GTACAAATTTATTTAATGTATATACATGGTCTATTAGCCAGGACCCTTTAGAGGGCCAGAACTAATAGGA TAGATGTATACATAAAGGGGAGTTTATTAAGGAGTAGTGAGTCACATGATCACAAGGTGACGTCCCACAG TAGGCCGTCTGCAAGCTGAGGAGCAAGGAAGCCAGTCCGAGTCCCAAAACCTCAAAAGTAGGGAAGCCGA CAGTGCAGCCTTCAGTCTGTGGTCAAAGGTCCAGGAGTCCAAAGGCTGAAGAACTTGGAGTTTGATGTTT GAGGGCAGGAAGCATCCAGCACAGGAGAAAGATGTAGGCTGGGAGACTAAGCCAGTCTAGTCTTTCCACA TTCTTCTGCCTACTTTCATTCTGGCTGTGCTGGCAGCTGATTAGATGGTGCCCACCCGGATTGAGGGTGG GCCTCCCTTTCTCAGTCCACTGATTCAAATGTTAATTTCCTTTGGCAACACCCTCACAGACACACCCAGG AACAATACTTTGAATCCTTCAATCCAATCAAGTTGACACTCAATATTAACCACCACACTTGGGAAACTTG AGAATGAAGACCCAACTTCCCAGTAAGTTACAGAAACTCATGTATTATTCCGAGGCCACAGTAAAGAGTG GAGACTCAAAGCATGGCCAGAAACAGGTAAATTAGTTTTAGTGGCAACACAGGTTAAGAGAGAGAGGAAG GAAGAAGCTCGGCTAGCAAAGGTGGCCTTGTTATGTAGACGAACCTTTTCTCAGAAGCAAAAGATGGTAA ATGTTTCTATCCAGATCTTTAAAGGTGTCAGACTCTCAATCGCTCTGGATCCTGGGAAAGGCTTAGAAAC AGGAGAGGGTATGGCTGCATTAATGGACATTGTCCACAGACGCAAATTTTCCTCAGTTAAGACAGTTTTG CAATGCCACTTCTGCTTGTTGGCCAGTGGAAACCATTTTTAAATATGTCAAAGAAATATATTTGAGGGTA AAATATTTTGATTTTCTTCAGTCCCCACTTTGAAATTTAAAACAAGTTTCACATACTAAAAGCCAAGGTA ATAGCTTTGGGGAGATTTAAGTTAGAGGTGTTTAGATAGAGACAGTCATAGCAGTGGAAAAACACATTTG GGATAAATATAAATGAGCAAATTTAAATATATCATTCCATATTTTCTTTAGGCAGTCCCTTGGTTTTGAG GTGAGATCAGTTCAGTTAAATATCTACGTCCCATTCCAGGAGGTGGGACTGCAAATGGTTTAGGCCTTTA GACGTAATGTAGGCAATCAGATTTCTAGTAGGAGGCATTTCTGTAGAAACAGAAAAAAATAAATAAATAA ATGTTACTATCTGGAGTAGTCTATATATCTAGAAAAGCTAGTCTATAGCTTTTTCTCTGAGGCGTCTTCA TATTGCAGTGGCAATGTCCCAGATTTCCCTGGAAGTTCAAACCAGGTGTTCCACTGAACTTTCTGAGAAG GCCTCACATCAGCAGATATGCATGAAGGTTGTTTATAAGTTACTGTTATTTTCTCCTGATACCTTCAGTT TGCAAGACTTTAAGAAAACCCCAGTTTTAATTTCTAGTGAATTCAAGTAAGAAAAATGGGAGAAAACGTT GAAAATGTTACTTTGCAGACTTGTAGCCAGAAAAAAATTCAGGATTTGGTCTAACTTGTAAAAAATAATA AAAACTGAAAAAACAATGGGCAAGGCTAGAAGATACTAACAGATACACTATAGTTTTTGAAACATAGTAT TTCTGCTTCCAGTTCTTCAATTTTATGAAAGACATAGTTTCATGCACATCCGTGTGAAGAGACCACCAAA CAGACTCTGTGTGAGCAACATGGCTGTTTATTTCACCTGGGTGCAGGCGGGCTGAGTCCTAAAAGAGAGT CAGTGAAGGGAGATAAGGGTGGGGCCATTTTATAGGATTTGGATAGATAAAAGAAAAGTACAGTCAAAGG GGGGTTGTTCTCTGGCAGGCAGAGTGGGGGTCACAAGGTGCTCAGTAGGGGAGCTATTGAGCCAGGATGA GCCAGGAGAAGGAATTTCACAAGACAGTGTCATCAGTTAAGGCAGGAACAGGCCATTTTCCCATCTTTTG TGGTGGAATGTCATCAGTAAGGCAGGAACCGGCCATCTGGATGTGTACATGCAGGTCACGGGATATGATG GCTTAGCTTAGGCTCAGAGGCCTGACACACAGTAGAACTGATTTATTTGCAAAATAAGTTTTGTTACTAT ACTTGGTCTGATTTTTTGCATAAAGGGCAGCAAGAATAATTATTTACTATATAGGCTCCTTTTTAAAAAA TGGCTTTGCTGGAACATTCTTTTTTGTAAAGAATCTCATATTAGACCTCTTAAAAGCATCCTGAGCCCAA CCAAGGATTTATCTGTTTCTACGAGATACCTGTATGAATTAAGTGAATTCTCTCTCAAGGTCCCAAAATA AGTTGGGGTTCCTGGGCCTGTCAGAATGTGACCTTCTTTTACCCATTACAGGCCAGAAACCTGTAAAGGA ACCTGTAAAGGAACTGCATAGACAAGCTGTGAGGCCAGTTTTATCCACAGGGCTATTATCAGCTTTATAA AGTCCCAATATCAATTTCTTAAAAATAGGGCATTCCAGTCAAATCCTTGATTTTTGTCTCCACTTGTGGC CTGTTACAAAACAAAACAGATTCTAACTGAATTTATGCAAATAATTATATTCCCATAAATTAGCAATAAT CACTAAGAGTTTCCAAATTTCAGAGAAATCAGGCAGATAGAGGGAAATATGCTTCAAATTTTGCTCACAA GAGTATACTTTACACAAATATTAAAAGCTGTAAATGTCTAAAAAGAAAAAAATTTTGACTCTGAAAAACA AAAGTGGCAATGTTTCAACAAAACCCATAAAAAGATTATTTCAGTCTTCTATTATTTCAGTCCATGCAAT TAACTCCTATTCTGTTAGATATTGGGTGAGCAATCTTCATGAACATATTAGTTCTCCATGAGAGTCCTGG GAGTTTTTTTTCTCTATACCAGTGGCACAATCTCCAAAGTTATCATAAAGCTTCATTCAAAAGCACCCCT TAGAGTCCTATAGCTAATTGCAAACCACCTTTTTAAAAGCACCAAAGTAGAACAACTGTCAATGACAGAA GTCTTAGGACAGCCATGGTCAAGGACACACTTAACAAGGAAATTTGGTTATTTCTGTGGCATATAACAAT TTAACATAATAATTATAAATACTAATAACATATATAAAGACATCAGAATGATAGGAATATCACGCAATGT TGAAAAACATACTAGTAACAGGTTTAATATAAATGTAGAACAAATAAAGTTGAACACCATTTCATATTTG ACAATGTTTCCTATATGATTTTAACATGCCAAATACACCGAATATGTCTGTTTTTGGCTTCAGGGGACTT AATATCAAAAAAGATAATGAGGTCAACAAGACTGAATTTAGAATTTGATTTTGGAAAGTTTGATTTTCTT CAGTCCCCACTTTGAAACTTAAAACAAGTTTCATATATTAAAAGCCAAGGTAATAGCTTTGGAGAGATTT GGGTTACGGGTATTTAGATAGAGACAGATATTGTGGTGGAAAAACAAATTACAATCACCAAACAGGTCAT TGTAAATAAGTCATTCATTTAGGCAAAGTGATAACTCAAAGATTTCAAAAAGTAAAAACCTTCACTCTTT GAGAGAGAGGACTCACTTTCACAAACAATAAGACCTAATAAAGACAGCATGAGGCCAACTAAATTTGTCT CTCTTCCCCAACCCATCTTTTTTTTTTTTTTTTTGCAGTTTTCTCAAAAGGTAAGCAAAAATCTTTCACT ATCTCTTAATATTAAAAGAAAATCTTATTCAAAGGAAATCTAAATTTTACCATTGCATAGCTTATTATTA ATGCTAAAGTTAGCATTAATAAAATCTTACAAACAAATCTATTTAATTAGTTGTAACACAAGGTAGAGAT TTTTATAAATCTTTTACAACATTTTATAATTTTCCATAAAAGAGCAGATTAGTATTCTAATAAAACCCTG ATATTTTGACATAAGGGCCTAGATTCTGGCCCTGAATTAGTATGCTTTTTATTTTAAGGTTTAATTTATG CAAAAACTAAATAATCCCTTTCAAATTTTAGCCAGCTGGCTTATATATAGAATTCCTTTTACAAGATCAA TGATCAATCTTTCATAAACCTTTAGTTTTGTCCACATTTTTAACTTAAAACAATCTTTAAAATCTAAAAA ATTTTTTTTTGTTCTTTTGAGACCGAATCTCACTCTGTCAGCCAGGCTGGAGTGCCTGCCTCCAGGGTTC AAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGCTGTGCATGACCACACCCGCCTAATT TTTGTATTTTTAGTAGAGACGGGGTTTCACCACGTTGGTCAGGATGGTCTCGAACCCCTGACCTCGTGAT CTGCCCACCTTGGCTTCCCAAAGTGCTGGGATGACAGGCATGAACCAATGCACCCAGCCTGTAATTTTTT AAATAAATAAGACTAGCTTAATATTCGTTTCATAAAAACAGCTAAATCCTGAGCTATCTGTAAAAAAATA CGTTTAACATTAAGGTTTATACTTGGGTGAACACCTGATATTCACAGGCTATAAAATAGTTAGCAAGGAA ATAACTTTAAATGTGACTAGTTTTGTCTAATGTCTCAGTTCTCAAAGCAATCTAGGTAAACTGCTAACAA TGAATAAATTGAACAAATATAAGTGGGATGGATAAATGCTTGTTGGTTAACTTTTATGTAATTTAAAATC TTAAACTTATTTTGGATTAAAGAACAGCTACTCATTAATAGTTTGGCTCATTTCCAATTAAGTAGAGATA TGGAGAAACATGCCTAAAAATTATAGAGTGATTTCATCTATAAAGTACTGATACCTGATATGCAGTTTAG GATTTCATGTTTCCTAGGTTTAAGGTCACTAAAAATAAAAATTCCACTTAATATATAATTCTGTTTATAA AGTCTGTCAAAGACATGTTTTTGATGAAAAAAGAAAATAATATAAGACAAATAGAAAAATGTATTCTCAT TAAAAAGAAAATCACTTTTGTCTAATTCAAAGGTTATTTATGAAACAAAGTAAAAAGGAACCAGTAAATA GGGGAAAGAGATGTAAAGAAAGTTATAGATATAAAGATGTATTTGTGATAAGAGAGATTAAAAAGAAAAG AGAATTATTTTGTATGATAAATAATTTTATATTTTTTTCTGAAGTAAGATGACTGGTAATCTAAGAAAGA GGGAAATTTAGGATACAATGGAAAGTCCAATCATGTTGGAAGTGGCATGTGTATAATCAAATTCATAAAA GAAATTTTGTTTGTGGTTATGTTGGCTTTAATTAAAATTGAATTATTTATAGTCGTCTTTCTGGAAACTG AGCTTTGACCAAAAAAACCACAATACAAAACCAAAACATTGGTTAGAGCAATAAGGGTTTCTTAAAGTAT TGATTTGCTCTTCATTAAATTCCAAGAAGTTTTAATGTTTAATGCTATTTTTTTCTTTTTGAAACTTCTC AGATATCTCAGAAGTTCAACTTCTGGTGTATCCTGCTGCTTTTAGCCTTTTCTTCATTTGAGAATAGCTG AGATCTTAACTCTCTCTTTCAACTTTTTGTTGGCTCTGGCAAATTTTTTTTTTCTTCAGGTCTAAATCTG TTGCTATAGCCTGATGCTGAAGTGTTTCGTCTTAAAGCTTCAAAAAAAGCAATGTTTTCTTCCATTATCA CTTAATTCTGTGCTGTTGGCTTTTCCTCCTATGAGTAAGGGCCAGAAACCCTCTGAAGGATTACTGAAAA ATCAACTCACAAAAGATAGATCAGTTGAAGAGAAGGCATGCAGATTTGTTTGGAGTGTGTATGCTGGAGT CTTCAGAATAAAGACCCCAACACACAGGGGAAATTGTCCTTTTTATGCTTAGGTGCGACAAGGTATGGGC ACATATAAAAATATGATTGAGGCAAAAGGCATAACCTAATGCCAATGGACTGGGGAAACCCAGCAAGACC TGTCTGTCTAGATTCCTCTTGACCTCTCTGAGCATGTACTCCTTCCTTCTGGGTATAGGGATCTTATGAC CTACAATCCAACAAGGTAAGTTGGATAATTTCTTTATGGCTAATTCATACACAGAAAGGGAGAGGGCAAA TTAGAGTAATATTTTTAGACTTTGTGGCTGGTTTTGAGAAAAAGGAGTTCTGATTTCTAGGTTCTGCCTT GGGGAAAGAGATTCTAGTTTGTTTGGCCAGCTTTGAGGGATATTGGGACTGAGAGATAGGAGGCCAGGAG AAGGCCAAAGAAAAACTGACTTCTGAAGCTTTTACCTTGGGGCACTGTCTTCTGAGCTACAACGTGTATT TAAAGTCTTCGACGAAACCATGAAACTTCCTATGCTGGTACTAAGAGTCACGTATTCCCCTGCTCAAGTT ACTAGTAAATTCTTTGTTAGTATTGTTCTTCAGTGGGTTCTCCCCAGTAGCTTTGGGTTGATATCCTCCC AGCTTCTAGCCTTGCAGCATAATACATGTGCTTAGATTTCAGCAAAAATGCCTCAATAGAGTTTCAATGA TCTACTTAGGTCACATGCCACCCATCAGCCAAGCTTTGGTCCTAGAGCTGTTGTGTTTGAAGTGGTCCTA CATAGTTTATGTGACAGCCCATAGAGCTCAATATGGGCAGCCTATTGTCCACACAGTAGCTAGACAGATC ACTTTGATTAGGCGAACACTGTTCCGCTTATAACCCTTCTCTCATCCTGTCTCACTTTGATTTCTCATCT CGTTTAGAATAGAAGCCAAAATATAAGCATTGGCTCCAAGGCCACTGTTAGTTGTCAGATATCATCTCAA TCCATTCCCCTTCTCACTGACTGTGCTCCAGTCACCCTGGCTTCCTGGATGTTTCCTCAACACTTGGGAC AGGTTCCAGCTAAGGATCCTGGTACTTTCTGTTCCACTGCATGGAACAATCCTCCTCACACATATCCACA GAACTTATTCTCTAGCATCCTTAAAGTCTTAGTGAGCCTTTCTTTAACCACCTTGTTTGAATTCAGTGCT CTCCCTGTGCACCCACTAACCCCTCTTTTTGTTTTCACCAGGCACTTACCACAATCTAACAGACTGCATG TTTTATCCATTTATTCAGTTTCCTATTTGTGTCCCTTCAACTCCCATTAAAATATAATATTTTTGAGGGC AAGCAAGTACTAGAACAATAGGAAACACATCAAGAGTATTCTGTAAACTATTTCTTGAATCAATCAGTGA ATGAATGAATTAATCAATATATTTTTTGAGTGAGGAGCTTTGTGTTAGGTACAGCTAAATGGGAAATCAA GTGGGTCATGTACCATGAATACCATATACTCTACTGTATAATTCTCCTGCTTATATCAGAAACTGTTTAT AAGCCTATTATAATTGATACCAATTGGAATCTCTTTTTTACTCATCACCAAGAACACCACAAACAAGTTG TTTACCATTTGGCTCCTTATTTAATCTGGATTTCCAACTCCTCATGCTTAAAAGACGGAAGATACAATAA TACTTTCCTTACAGGGTTCTGAGACTACTAAGAGAACTTATGCATGTAAAAGGGATTCATGCAGTAGAAA TACTAACAAAAGAATTACTATGACAGATACTTATAACCATTGTGTTTTTACGTATTTAAAATACGTTATA CCTATAATTAGTCACACGAGGAAATCAAATGCTAAAGTATGATATGTTTTTATGTTTTGTTTTTCTTGCT TAGGGGATCATGGACATTGAAGCATATTTTGAAAGAATTGGCTATAAGAACTCTAGGAACAAATTGGACT TGGAAACATTAACTGACATTCTTGAGCACCAGATCCGGGCTGTTCCCTTTGAGAACCTTAACATGCATTG TGGGCAAGCCATGGAGTTGGGCTTAGAGGCTATTTTTGATCACATTGTAAGAAGAAACCGGGGTGGGTGG TGTCTCCAGGTCAATCAACTTCTGTACTGGGCTCTGACCACAATCGGTTTTCAGACCACAATGTTAGGAG GGTATTTTTACATCCCTCCAGTTAACAAATACAGCACTGGCATGGTTCACCTTCTCCTGCAGGTGACCAT TGACGGCAGGAATTACATTGTCGATGCTGGGTCTGGAAGCTCCTCCCAGATGTGGCAGCCTCTAGAATTA ATTTCTGGGAAGGATCAGCCTCAGGTGCCTTGCATTTTCTGCTTGACAGAAGAGAGAGGAATCTGGTACC TGGACCAAATCAGGAGAGAGCAGTATATTACAAACAAAGAATTTCTTAATTCTCATCTCCTGCCAAAGAA GAAACACCAAAAAATATACTTATTTACGCTTGAACCTCGAACAATTGAAGATTTTGAGTCTATGAATACA TACCTGCAGACGTCTCCAACATCTTCATTTATAACCACATCATTTTGTTCCTTGCAGACCCCAGAAGGGG TTTACTGTTTGGTGGGCTTCATCCTCACCTATAGAAAATTCAATTATAAAGACAATACAGATCTGGTCGA GTTTAAAACTCTCACTGAGGAAGAGGTTGAAGAAGTGCTGAGAAATATATTTAAGATTTCCTTGGGGAGA AATCTCGTGCCCAAACCTGGTGATGGATCCCTTACTATTTAGAATAAGGAACAAAATAAACCCTTGTGTA TGTATCACCCAACTCACTAATTATCAACTTATGTGCTATCAGATATCCTCTCTACCCTCACGTTATTTTG AAGAAAATCCTAAACATCAAATACTTTCATCCATAAAAATGTCAGCATTTATTAAAAAACAATAACTTTT TAAAGAAACATAAGGACACATTTTCAAATTAATAAAAATAAAGGCATTTTAAGGATGGCCTGTGATTATC TTGGGAAGCAGAGTGATTCATGCTAGAAAACATTTAATATTGATTTATTGTTGAATTCATAGTAAATTTT TACTGGTAAATGAATAAAGAATATTGTGGAAAAAC Download Select all
Length	9975
OMIM ID	612182
HGNC ID	HGNC:7646
Unigene ID	Hs.2
Ensembl ID	ENSG00000156006
PharmGKB ID	PA18

mRNA Information

mRNA ID	NM_000015.2
Exon	join(1..101,8754..9969)
mRNA Sequence	>10 TGAGATCACTTCCCTTGCAGACTTTGGAAGGGAGAGCACTTTATTACAGACCTTGGAAGCAAGA GGATTGCATTCAGCCTAGTTCCTGGTTGCTGGCCAAAGGGATCATGGACATTGAAGCATATTTT GAAAGAATTGGCTATAAGAACTCTAGGAACAAATTGGACTTGGAAACATTAACTGACATTCTTG AGCACCAGATCCGGGCTGTTCCCTTTGAGAACCTTAACATGCATTGTGGGCAAGCCATGGAGTT GGGCTTAGAGGCTATTTTTGATCACATTGTAAGAAGAAACCGGGGTGGGTGGTGTCTCCAGGTC AATCAACTTCTGTACTGGGCTCTGACCACAATCGGTTTTCAGACCACAATGTTAGGAGGGTATT TTTACATCCCTCCAGTTAACAAATACAGCACTGGCATGGTTCACCTTCTCCTGCAGGTGACCAT TGACGGCAGGAATTACATTGTCGATGCTGGGTCTGGAAGCTCCTCCCAGATGTGGCAGCCTCTA GAATTAATTTCTGGGAAGGATCAGCCTCAGGTGCCTTGCATTTTCTGCTTGACAGAAGAGAGAG GAATCTGGTACCTGGACCAAATCAGGAGAGAGCAGTATATTACAAACAAAGAATTTCTTAATTC TCATCTCCTGCCAAAGAAGAAACACCAAAAAATATACTTATTTACGCTTGAACCTCGAACAATT GAAGATTTTGAGTCTATGAATACATACCTGCAGACGTCTCCAACATCTTCATTTATAACCACAT CATTTTGTTCCTTGCAGACCCCAGAAGGGGTTTACTGTTTGGTGGGCTTCATCCTCACCTATAG AAAATTCAATTATAAAGACAATACAGATCTGGTCGAGTTTAAAACTCTCACTGAGGAAGAGGTT GAAGAAGTGCTGAGAAATATATTTAAGATTTCCTTGGGGAGAAATCTCGTGCCCAAACCTGGTG ATGGATCCCTTACTATTTAGAATAAGGAACAAAATAAACCCTTGTGTATGTATCACCCAACTCA CTAATTATCAACTTATGTGCTATCAGATATCCTCTCTACCCTCACGTTATTTTGAAGAAAATCC TAAACATCAAATACTTTCATCCATAAAAATGTCAGCATTTATTAAAAAACAATAACTTTTTAAA GAAACATAAGGACACATTTTCAAATTAATAAAAATAAAGGCATTTTAAGGATGGCCTGTGATTA TCTTGGGAAGCAGAGTGATTCATGCTAGAAAACATTTAATATTGATTTATTGTTGAATTCATAG TAAATTTTTACTGGTAAATGAATAAAGAATATTGTGG Download Select all
Length	1317

CDS Information

Location	8760..9632
CDS Sequence	>gi\|116295259:108-980 Homo sapiens N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2), mRNA ATGGACATTGAAGCATATTTTGAAAGAATTGGCTATAAGAACTCTAGGAACAAATTGGACTTGGAAACAT TAACTGACATTCTTGAGCACCAGATCCGGGCTGTTCCCTTTGAGAACCTTAACATGCATTGTGGGCAAGC CATGGAGTTGGGCTTAGAGGCTATTTTTGATCACATTGTAAGAAGAAACCGGGGTGGGTGGTGTCTCCAG GTCAATCAACTTCTGTACTGGGCTCTGACCACAATCGGTTTTCAGACCACAATGTTAGGAGGGTATTTTT ACATCCCTCCAGTTAACAAATACAGCACTGGCATGGTTCACCTTCTCCTGCAGGTGACCATTGACGGCAG GAATTACATTGTCGATGCTGGGTCTGGAAGCTCCTCCCAGATGTGGCAGCCTCTAGAATTAATTTCTGGG AAGGATCAGCCTCAGGTGCCTTGCATTTTCTGCTTGACAGAAGAGAGAGGAATCTGGTACCTGGACCAAA TCAGGAGAGAGCAGTATATTACAAACAAAGAATTTCTTAATTCTCATCTCCTGCCAAAGAAGAAACACCA AAAAATATACTTATTTACGCTTGAACCTCGAACAATTGAAGATTTTGAGTCTATGAATACATACCTGCAG ACGTCTCCAACATCTTCATTTATAACCACATCATTTTGTTCCTTGCAGACCCCAGAAGGGGTTTACTGTT TGGTGGGCTTCATCCTCACCTATAGAAAATTCAATTATAAAGACAATACAGATCTGGTCGAGTTTAAAAC TCTCACTGAGGAAGAGGTTGAAGAAGTGCTGAGAAATATATTTAAGATTTCCTTGGGGAGAAATCTCGTG CCCAAACCTGGTGATGGATCCCTTACTATTTAG Download Select all
CCDS ID	CCDS6008.1

Protein Information

Protein ID	NP_000006.2
Protein Name	N-acetyltransferase 2 (arylamine N-acetyltransferase)
Molecular Wt. (Da)	33439
Protein Sequence	>10 MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGQAMELGLEAIFDHIVRRNR GGWCLQVNQLLYWALTTIGFQTTMLGGYFYIPPVNKYSTGMVHLLLQVTIDGRNYIVDAGSGSS SQMWQPLELISGKDQPQVPCIFCLTEERGIWYLDQIRREQYITNKEFLNSHLLPKKKHQKIYLF TLEPRTIEDFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILTYRKFNYKDNTDLVEFK TLTEEEVEEVLRNIFKISLGRNLVPKPGDGSLTI Download Select all
Length	290
Uniprot ID	P11245
Ensembl Protein ID	ENSP00000286479

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

EC	2.3.1.5
Name	arylamine N-acetyltransferase arylamine acetylase beta-naphthylamine N-acetyltransferase 4-aminobiphenyl N-acetyltransferase acetyl CoA-arylamine N-acetyltransferase 2-naphthylamine N-acetyltransferase arylamine acetyltransferase indoleamine N-acetyltransferase N-acetyltransferase (ambiguous) p-aminosalicylate N-acetyltransferase serotonin acetyltransferase serotonin N-acetyltransferase
Class	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups
Sysname	acetyl-CoA:arylamine N-acetyltransferase
Substrate	acetyl-CoA [CPD:C00024]; arylamine
Product	CoA [CPD:C00010]; N-acetylarylamine
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Caffeine metabolism	hsa00232
Chemical carcinogenesis	hsa05204
Drug metabolism - other enzymes	hsa00983
Metabolic pathways	hsa01100

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam00797	20-280	Acetyltransf_2
cl00949	20-280	Acetyltransf_2 superfamily
COG2162	1-245	NhoA
PRK15047	3-169	PRK15047

Ontology Information

HPRD ID	2000
Molecular Class	Enzyme: Acyltransferase
Molecular Function	Acyltransferase activity (GO:0008415)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P11245 DB00250 Dapsone SmallMoleculeDrug
P11245 DB00316 Acetaminophen SmallMoleculeDrug
P11245 DB00951 Isoniazid SmallMoleculeDrug
P11245 DB01015 Sulfamethoxazole SmallMoleculeDrug
P11245 DB01068 Clonazepam SmallMoleculeDrug
P11245 DB04953 Ezogabine SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Uniprot ID	DrugBank ID	Name	Type
P11245	DB00250	Dapsone	SmallMoleculeDrug
P11245	DB00316	Acetaminophen	SmallMoleculeDrug
P11245	DB00951	Isoniazid	SmallMoleculeDrug
P11245	DB01015	Sulfamethoxazole	SmallMoleculeDrug
P11245	DB01068	Clonazepam	SmallMoleculeDrug
P11245	DB04953	Ezogabine	SmallMoleculeDrug

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO