Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDH3 | 1001 | cadherin 3, type 1, P-cadherin (placental) | 16 | CDHP, PCAD |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26167814 | 2015 | Cell line : - Source : Home institution Clinical Department of General, Colorectal, and Trauma Surgery of the School of Health Sciences, Medical University of Silesia. Sample Type : CRC tumor No. of Sample : 64 Stage : - | Oligonucleotide microarrays,real time RT-PCR | Up-regulation | - | Two coding E-cadherin (CDH1) with the lower expression, and P-cadherin (CDH3) with higher expression in CRC tissue. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015] |
| Chromosome | 16 |
| Location | 16q22.1 |
| Start | 68678151 |
| End | 68732959 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 54809 |
| OMIM ID | 114021 |
| HGNC ID | HGNC:1762 |
| Unigene ID | Hs.191842 |
| Ensembl ID | ENSG00000062038 |
| PharmGKB ID | PA26299 |
mRNA Information
| mRNA ID | NM_001793.5 |
|---|---|
| Exon | join(1..1177,1389..1503,32138..32223,33887..34030, 34254..34409,34515..34659,35552..35727,36721..36849, 38055..38240,40336..40577,40958..41103,43265..43489, 47473..47679,51008..51138,51530..51676,53944..54807) | mRNA Sequence | Download Select all |
| Length | 3706 |
Protein Information
| Protein ID | NP_001784.2 |
|---|---|
| Protein Name | cadherin 3, type 1, P-cadherin (placental) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 829 |
| Uniprot ID | Q15233 |
| Ensembl Protein ID | ENSP00000276079 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 219-324 | Cadherin_repeat |
| cl15786 | 219-324 | CA_like superfamily |
| cd11304 | 333-436 | Cadherin_repeat |
| cl15786 | 333-436 | CA_like superfamily |
| cd11304 | 446-544 | Cadherin_repeat |
| cl15786 | 446-544 | CA_like superfamily |
| pfam01049 | 678-826 | Cadherin_C |
| cl03079 | 678-826 | Cadherin_C superfamily |
| cd00031 | 113-211 | CA_like |
| cl15786 | 113-211 | CA_like superfamily |
| smart00112 | 238-326 | CA |
| pfam00028 | 333-432 | Cadherin |
| pfam00028 | 220-319 | Cadherin |
| smart00112 | 350-438 | CA |
| pfam00028 | 113-206 | Cadherin |
| pfam00028 | 446-527 | Cadherin |
| smart00112 | 463-546 | CA |
| smart00112 | 136-213 | CA |
| cd11304 | 114-211 | Cadherin_repeat |
| pfam00028 | 551-638 | Cadherin |
| cl15786 | 551-638 | CA_like superfamily |
| smart01055 | 27-88 | Cadherin_pro |
| cl07391 | 27-88 | Cadherin_pro superfamily |
| pfam08758 | 26-96 | Cadherin_pro |
Ontology Information
| HPRD ID | 1225 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.