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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BCL2L11 | 10018 | BCL2-like 11 (apoptosis facilitator) | 2 | BAM; BIM; BOD |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22322955 | 2012 | Cell line : HCT 116 Source : Kyushu University Hospital at Beppu and affiliated hospitals, ATCC. Sample Type : CRC tumor and normal tissue No. of Sample : 88 Stage : - | real time RT-PCR | Down-regulation | - | miR-10b directly inhibits pro-apoptotic BIM, and the overexpression of miR-10b confers chemoresistance in colorectal cancer cells to 5-FU. |
| 20348947 | 2010 | Cell line : HCT 117 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western blotting , Immunohistochemistry, PGE2 quantification, Apoptosis assays | Phosphorylation | - | COX-2/PGE(2) pathway as an important negative regulator of Bim expression in colorectal tumours and suggest that Bim repression may be an important step during colorectal cancer tumorigenesis. Repression of Bim expression was dependent upon PGE(2)-mediated activation of the Raf-MEK-ERK1/2 pathway, which promoted Bim phosphorylation and proteasomal degradation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013] |
| Chromosome | 2 |
| Location | 2q13 |
| Start | 111120618 |
| End | 111168445 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 47828 |
| OMIM ID | 603827 |
| HGNC ID | HGNC:994 |
| Unigene ID | Hs.469658 |
| Ensembl ID | ENSG00000153094 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011510463.1 |
|---|---|
| Exon | join(1..571,2485..2486,3116..3522,29427..30338) | mRNA Sequence | Download Select all |
| Length | 1892 |
CDS Information
| Location | join(536..571,2485..2486,3116..3522,29427..29653) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001191035.1 |
|---|---|
| Protein Name | BCL2-like 11 (apoptosis facilitator) |
| Molecular Wt. (Da) | 12585 |
| Protein Sequence | Download Select all |
| Length | 108 |
| Uniprot ID | P54753 |
| Ensembl Protein ID | ENSP00000332118 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 104 |
| T | Phosphorylation | 116 |
| S | Phosphorylation | 118 |
| S | Phosphorylation | 59 |
| S | Phosphorylation | 69 |
| S | Phosphorylation | 77 |
| T | Phosphorylation | 56 |
| S | Phosphorylation | 58 |
| T | Phosphorylation | 56 |
| S | Phosphorylation | 58 |
| S | Phosphorylation | 59 |
| S | Phosphorylation | 69 |
| S | Phosphorylation | 77 |
| S | Phosphorylation | 59 |
| S | Phosphorylation | 69 |
| S | Phosphorylation | 77 |
| S | Phosphorylation | 77 |
| S | Phosphorylation | 77 |
| S | Phosphorylation | 77 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;in vivo | 943 063 010 198 631 000 000 000 000 000 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vitro;in vivo | 118 593 721 019 863 000 000 000 000 000 000 000 000 |
| 599 | BCL2L2 | 3569 | NP_004041.1 | in vitro;in vivo;yeast 2-hybrid | 9 430 630 973 171 010 000 000 |
| 8655 | DYNLL1 | 3334 | NP_003737.1 | in vitro;in vivo;yeast 2-hybrid | 1 019 863 112 591 950 |
| 399664 | MEX3D | 15254 | NP_976049.3 | in vitro;yeast 2-hybrid | 14769789 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| FoxO signaling pathway | hsa04068 |
| MicroRNAs in cancer | hsa05206 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam08945 | 131-166 | Bclx_interact |
| cl07517 | 131-166 | Bclx_interact superfamily |
| pfam06773 | Apr-40 | Bim_N |
| cl06026 | Apr-40 | Bim_N superfamily |
Ontology Information
| HPRD ID | 586 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.