Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHAF1A | 10036 | chromatin assembly factor 1, subunit A (p150) | 19 | CAF1P150, CAF1B, CAF-1, CAF1, P150, MGC71229 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24845563 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 203 Stage : - | CHAF1A knockdown,colony formation assay | Up-regulation | - | CHAF1A upregulation functions as a poor prognostic indicator of colon cancer, potentially contributing to its progression by mediating cancer cell proliferation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008] |
| Chromosome | 19 |
| Location | 19p13.3 |
| Start | 4402660 |
| End | 4443394 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 40735 |
| OMIM ID | 601246 |
| HGNC ID | HGNC:1910 |
| Unigene ID | Hs.79018 |
| Ensembl ID | - |
| PharmGKB ID | PA26446 |
Protein Information
| Protein ID | NP_005474.2 |
|---|---|
| Protein Name | chromatin assembly factor 1, subunit A (p150) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 956 |
| Uniprot ID | P85298 |
| Ensembl Protein ID | ENSP00000337287 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 141 |
| S | Phosphorylation | 206 |
| S | Phosphorylation | 203;- |
| S | Phosphorylation | 199;- |
| S | Phosphorylation | 772;- |
| Y | Phosphorylation | 780;- |
| T | Phosphorylation | 783;- |
| T | Phosphorylation | 154;- |
| S | Phosphorylation | 65;- |
| S | Phosphorylation | 224 |
| T | Phosphorylation | 722 |
| S | Phosphorylation | 951 |
| T | Phosphorylation | 770 |
| S | Phosphorylation | 775 |
| S | Phosphorylation | 777 |
| T | Phosphorylation | 778 |
| T | Phosphorylation | 779 |
| S | Phosphorylation | 873 |
| T | Phosphorylation | 949 |
| T | Phosphorylation | 865 |
| S | Phosphorylation | 143 |
| T | Phosphorylation | 259 |
| S | Phosphorylation | 767 |
| S | Phosphorylation | 862 |
| S | Phosphorylation | 83 |
| T | Phosphorylation | 266 |
| S | Phosphorylation | 255 |
| S | Phosphorylation | 123 |
| S | Phosphorylation | 129 |
| S | Phosphorylation | 138 |
| S | Phosphorylation | 310 |
| T | Phosphorylation | 330 |
| T | Phosphorylation | 454 |
| S | Phosphorylation | 787 |
| S | Phosphorylation | 794 |
| S | Phosphorylation | 868 |
| S | Phosphorylation | 876 |
| S | Phosphorylation | 308 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro | 16826239 |
| 4152 | MBD1 | 1133 | NP_056671.2 | in vivo;yeast 2-hybrid | 1 269 782 217 066 070 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vitro;in vivo;yeast 2-hybrid | 1 064 860 616 826 230 |
| 8208 | CHAF1B | 3147 | NP_005432.1 | in vivo | 9614144 |
| 8353 | HIST1H3E | 11907 | NP_003523.1 | in vitro;in vivo | 1 566 419 817 081 970 |
| 10155 | TRIM28 | 3445 | NP_005753.1 | in vitro | 10938122 |
| 10926 | DBF4 | 10371 | NP_006707.1 | in vivo;yeast 2-hybrid | 16826239 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam15539 | 665-956 | CAF1-p150_C2 |
| cl21343 | 665-956 | CAF1-p150_C2 superfamily |
| pfam15557 | 1-229 | CAF1-p150_N |
| cl21359 | 1-229 | CAF1-p150_N superfamily |
| pfam12253 | 557-601 | CAF1A |
| cl13660 | 557-601 | CAF1A superfamily |
| pfam11600 | 266-479 | CAF-1_p150 |
Ontology Information
| HPRD ID | 13061 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.