Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24898286 | 2015 | Cell line : HCT 116 Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 131 Stage : - | SSCP and DNA sequencing | Polymorhpism | - | CDH10, CDH24 and DCHS2 genes harbored frameshift mutations. These mutations might inactivate the cell adhesion-related functions and could be a feature of GC and CRC with MSI-H. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015] |
| Chromosome | 5 |
| Location | 5p14.2 |
| Start | 24487209 |
| End | 24645085 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 157877 |
| OMIM ID | 604555 |
| HGNC ID | HGNC:1749 |
| Unigene ID | Hs.92489 |
| Ensembl ID | ENSG00000040731 |
| PharmGKB ID | PA26283 |
mRNA Information
| mRNA ID | XM_011513923.1 |
|---|---|
| Exon | join(1..431,33886..33942,51412..51765,107351..107645, 109203..109322,109746..109913,133511..133698, 135206..135459,139777..139913,146506..146627, 152100..152208,153198..153449,156872..157925) | mRNA Sequence | Download Select all |
| Length | 3541 |
Protein Information
| Protein ID | XP_011512225.1 |
|---|---|
| Protein Name | cadherin 10, type 2 (T2-cadherin) |
| Molecular Wt. (Da) | 88321 |
| Protein Sequence | Download Select all |
| Length | 788 |
| Uniprot ID | P35228 |
| Ensembl Protein ID | ENSP00000327251 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 784 |
| T | Phosphorylation | 694 |
| S | Phosphorylation | 788 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1004 | CDH6 | 4305 | NP_004923.1 | in vivo | 10861224 |
| 5764 | PTN | 1199 | NP_002816.1 | yeast 2-hybrid | 16169070 |
| 10980 | COPS6 | 16735 | NP_006824.2 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 164-265 | Cadherin_repeat |
| cl15786 | 164-265 | CA_like superfamily |
| cd11304 | 273-380 | Cadherin_repeat |
| cl15786 | 273-380 | CA_like superfamily |
| cd11304 | 388-485 | Cadherin_repeat |
| cl15786 | 388-485 | CA_like superfamily |
| cd11304 | 73-156 | Cadherin_repeat |
| cl15786 | 73-156 | CA_like superfamily |
| cd11304 | 493-587 | Cadherin_repeat |
| cl15786 | 493-587 | CA_like superfamily |
| pfam01049 | 636-782 | Cadherin_C |
| cl03079 | 636-782 | Cadherin_C superfamily |
| smart00112 | 183-267 | CA |
| pfam00028 | 165-260 | Cadherin |
| smart00112 | 292-382 | CA |
| pfam00028 | 274-376 | Cadherin |
| smart00112 | 408-487 | CA |
| smart00112 | 80-158 | CA |
| pfam00028 | 493-587 | Cadherin |
| pfam00028 | 389-477 | Cadherin |
| smart00112 | 511-587 | CA |
| pfam00028 | 80-134 | Cadherin |
| cd00031 | 73-156 | CA_like |
Ontology Information
| HPRD ID | 1827 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Anti-apoptosis (GO:0006916) |
Drug Information
No matching records could be found.