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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CDH11 1009 cadherin 11, type 2, OB-cadherin (osteoblast)  16OB, CAD11 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24025712   2013Cell line : KM12C, KM12SM

Source : Mouse Model

Sample Type : -

No. of Sample : -

Stage : -

Mouse cytokine array,Cell proliferation, adhesion, migration, and invasion assays,Immunohistochemistry.Up-regulation-LTBP2, CDH11, OLFML3, and FSTL1 as selective biomarkers of cancer stroma, and CALU and CDH11 as candidate stromal biomarkers of prognostic significance in colon cancer.


Gene Details



NC_000016.9 (64916794..65160015, complement)

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Gene Type protein coding
Gene Family Cadherins / Major cadherins
Description This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]  
Chromosome 16
Location 16q21
Start 64916794  
End 65160015  
Strand -  
Gene Sequence

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Length 243222  
OMIM ID 600023   
HGNC ID HGNC:1750   
Unigene ID Hs.116471   
Ensembl ID ENSG00000140937   
PharmGKB ID PA26284   

mRNA Information


mRNA ID XM_005255762.1
Exon join(1..343,72185..72309,121072..121471,127257..127551, 133079..133198,134178..134345,137769..137956, 143812..144065,153073..153209,154049..154182, 154417..154534,175095..175346,178014..180887)  
mRNA Sequence

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Length 5408  



CDS Information


   
Location641..3031
CDS Sequence

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CCDS ID CCDS10803.1



Protein Information


      
Protein IDXP_005255819.1
Protein Namecadherin 11, type 2, OB-cadherin (osteoblast)
Molecular Wt. (Da)87835
Protein Sequence

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Length 796  
Uniprot IDP29474
Ensembl Protein ID ENSP00000297494  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation788

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1000CDH2226NP_001783.2in vivo14625392   
1499CTNNB1286NP_001895.1in vivo10029089   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11304163-264  Cadherin_repeat
cl15786163-264  CA_like superfamily
cd11304387-484  Cadherin_repeat
cl15786387-484  CA_like superfamily
cd11304272-379  Cadherin_repeat
cl15786272-379  CA_like superfamily
cd1130460-155  Cadherin_repeat
cl1578660-155  CA_like superfamily
pfam01049641-789  Cadherin_C
cl03079641-789  Cadherin_C superfamily
smart00112182-266  CA
pfam00028164-259  Cadherin
smart0011279-157  CA
smart00112406-486  CA
pfam00028391-479  Cadherin
pfam00028273-375  Cadherin
smart00112291-381  CA
pfam0002861-150  Cadherin
smart00112514-598  CA
cl15786514-598  CA_like superfamily
cd0003162-155  CA_like
cd00031431-484  CA_like


Ontology Information


   
HPRD ID1214
Molecular ClassCell junction protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO