Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDH11 | 1009 | cadherin 11, type 2, OB-cadherin (osteoblast)  | 16 | OB, CAD11  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24025712    | 2013 | Cell line : KM12C, KM12SM Source : Mouse Model Sample Type : - No. of Sample : - Stage : - | Mouse cytokine array,Cell proliferation, adhesion, migration, and invasion assays,Immunohistochemistry. | Up-regulation | - | LTBP2, CDH11, OLFML3, and FSTL1 as selective biomarkers of cancer stroma, and CALU and CDH11 as candidate stromal biomarkers of prognostic significance in colon cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]   |
| Chromosome | 16 |
| Location | 16q21 |
| Start | 64916794   |
| End | 65160015   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 243222   |
| OMIM ID | 600023    |
| HGNC ID | HGNC:1750    |
| Unigene ID | Hs.116471    |
| Ensembl ID | ENSG00000140937    |
| PharmGKB ID | PA26284    |
mRNA Information
| mRNA ID | XM_005255762.1 |
|---|---|
| Exon | join(1..343,72185..72309,121072..121471,127257..127551, 133079..133198,134178..134345,137769..137956, 143812..144065,153073..153209,154049..154182, 154417..154534,175095..175346,178014..180887)   | mRNA Sequence |    Download   Select all |
| Length | 5408   |
CDS Information
| Location | 641..3031 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10803.1 |    
Protein Information
| Protein ID | XP_005255819.1 |
|---|---|
| Protein Name | cadherin 11, type 2, OB-cadherin (osteoblast) |
| Molecular Wt. (Da) | 87835 |
| Protein Sequence |    Download   Select all |
| Length | 796   |
| Uniprot ID | P29474 |    
| Ensembl Protein ID | ENSP00000297494   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 788 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1000 |    CDH2 |    226 |    NP_001783.2 |    in vivo |    14625392    |
| 1499 |    CTNNB1 |    286 |    NP_001895.1 |    in vivo |    10029089    |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 163-264  | Cadherin_repeat |
| cl15786 | 163-264  | CA_like superfamily |
| cd11304 | 387-484  | Cadherin_repeat |
| cl15786 | 387-484  | CA_like superfamily |
| cd11304 | 272-379  | Cadherin_repeat |
| cl15786 | 272-379  | CA_like superfamily |
| cd11304 | 60-155  | Cadherin_repeat |
| cl15786 | 60-155  | CA_like superfamily |
| pfam01049 | 641-789  | Cadherin_C |
| cl03079 | 641-789  | Cadherin_C superfamily |
| smart00112 | 182-266  | CA |
| pfam00028 | 164-259  | Cadherin |
| smart00112 | 79-157  | CA |
| smart00112 | 406-486  | CA |
| pfam00028 | 391-479  | Cadherin |
| pfam00028 | 273-375  | Cadherin |
| smart00112 | 291-381  | CA |
| pfam00028 | 61-150  | Cadherin |
| smart00112 | 514-598  | CA |
| cl15786 | 514-598  | CA_like superfamily |
| cd00031 | 62-155  | CA_like |
| cd00031 | 431-484  | CA_like |
Ontology Information
| HPRD ID | 1214 |    
|---|---|
| Molecular Class | Cell junction protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
