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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21302622 | 2010 | Cell line : HCT 8 Source : - Sample Type : - No. of Sample : - Stage : - | siRNA silencing,Western blotting and immunofluorescent microscopy,real time RT-PCR,MTT and flow cytometry | Up-regulation | - | TSPAN1 plays an important role in colon cancer progression, and RNAi targeting of TSPAN1 may be a potential therapeutic strategy for the treatment of colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tetraspanins |
| Description | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1p33 |
| Start | 46640749 |
| End | 46651634 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10886 |
| OMIM ID | 613170 |
| HGNC ID | HGNC:20657 |
| Unigene ID | Hs.38972 |
| Ensembl ID | ENSG00000117472 |
| PharmGKB ID | PA134938100 |
Protein Information
| Protein ID | NP_005718.2 |
|---|---|
| Protein Name | tetraspanin 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 241 |
| Uniprot ID | O95238 |
| Ensembl Protein ID | ENSP00000363149 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 141;- |
| N | Glycosylation | 154;- |
| N | Glycosylation | 178;- |
| N | Glycosylation | 184;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03156 | 110-212 | uroplakin_I_like_LEL |
| cl02781 | 110-212 | tetraspanin_LEL superfamily |
| cd03161 | 128-211 | TM4SF2_6_like_LEL |
| cd03163 | 147-204 | TM4SF8_like_LEL |
| cd03155 | 126-211 | CD151_like_LEL |
| cd03127 | 128-212 | tetraspanin_LEL |
| cd03160 | 122-204 | CD37_CD82_like_LEL |
| cd03166 | 130-180 | CD63_LEL |
| cd03167 | 146-212 | oculospanin_like_LEL |
| cd03158 | 110-182 | penumbra_like_LEL |
| cd03165 | 137-212 | NET-5_like_LEL |
| pfam00335 | 6-240 | Tetraspannin |
Ontology Information
| HPRD ID | 5732 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Serine-type peptidase activity (GO:0008236) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.