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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TRAP1 | 10131 | TNF receptor-associated protein 1 | 16 | HSP75, HSP90L |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25493016 | 2014 | Cell line : - Source : University of Washington and the Cleveland Clinic Foundation in Cleveland via institutional internal tissue banks. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Immunohistochemistry, tissue microarrays ,Immunostaining | Up-regulation | - | Oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1, which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat shock proteins / HSPC |
| Description | This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| Chromosome | 16 |
| Location | 16p13.3 |
| Start | 3708038 |
| End | 3767598 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 59561 |
| OMIM ID | 606219 |
| HGNC ID | HGNC:16264 |
| Unigene ID | Hs.30345 |
| Ensembl ID | ENSG00000126602 |
| PharmGKB ID | PA36781 |
Protein Information
| Protein ID | NP_001258978.1 |
|---|---|
| Protein Name | TNF receptor-associated protein 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 704 |
| Uniprot ID | Q9Y337 |
| Ensembl Protein ID | ENSP00000337733 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| F | Proteolytic Cleavage | 59 |
| T | Phosphorylation | 494 |
| Y | Phosphorylation | 498 |
| Y | Phosphorylation | 366 |
| K | Acetylation | 424 |
| K | Acetylation | 466 |
| K | Acetylation | 332 |
| K | Acetylation | 382 |
| K | Acetylation | 431 |
| S | Phosphorylation | 282 |
| S | Phosphorylation | 341 |
| T | Phosphorylation | 153 |
| T | Phosphorylation | 174 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2131 | EXT1 | 598 | NP_000118.2 | in vitro;yeast 2-hybrid | 10545594 |
| 2132 | EXT2 | 599 | NP_000392.2 | in vitro;yeast 2-hybrid | 10545594 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo;yeast 2-hybrid | 87 566 269 312 071 |
| 7132 | TNFRSF1A | 1861 | NP_001056.1 | in vitro;yeast 2-hybrid | 7876093 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00075 | 112-220 | HATPase_c |
| cl00075 | 112-220 | HATPase_c superfamily |
| pfam00183 | 263-701 | HSP90 |
| cl20204 | 263-701 | HSP90 superfamily |
| pfam02518 | 113-217 | HATPase_c |
| pfam13589 | 113-220 | HATPase_c_3 |
| smart00387 | 113-258 | HATPase_c |
| PRK05218 | 87-702 | PRK05218 |
| COG0326 | 84-702 | HtpG |
| PTZ00272 | 85-697 | PTZ00272 |
| PTZ00130 | 75-682 | PTZ00130 |
| PRK14083 | 88-499 | PRK14083 |
| TIGR00585 | 113-307 | mutl |
| COG0323 | 113-295 | MutL |
| TIGR01052 | 89-227 | top6b |
| COG1389 | 77-260 | COG1389 |
Ontology Information
| HPRD ID | 6456 |
|---|---|
| Molecular Class | Heat shock protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.