Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
AKAP9 10142 A kinase (PRKA) anchor protein 9  7KIAA0803, AKAP350, AKAP450, CG-NAP, YOTIAO, HYPERION, PRKA9, MU-RMS-40.16A, PPP1R45, LQT11 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25446987   2015Cell line : HCT116, SW480, SW620, LoVo, CaCo 2, HT 29, Lst174 t, COLO205

Source : Nanfang Hospital. Cells obtained from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China).

Sample Type : CRC tumor

No. of Sample : -

Stage : TNM Stage II,III

Wound healing assay,Invasion assay,Microarray,Colony formation assay,Cell proliferation assay and cell cycle analysis,Western blotting ,2D gel electrophoresis ,ImmunofluorescenceUp-regulation-AKAP-9 was highly expressed in CRC cells with metastatic potential and human primary CRC tissues with lymph node metastasis


Gene Details



NC_000007.13 (91570181..91739987)

View Larger Image
   
Gene Type protein coding
Gene Family A-kinase anchor proteins, "Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits"
Description The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]  
Chromosome 7
Location 7q21-q22
Start 91570181  
End 91739987  
Strand +  
Gene Sequence

   Download   Select all

Length 169807  
OMIM ID 604001   
HGNC ID HGNC:379   
Unigene ID Hs.651221   
Ensembl ID ENSG00000127914   
PharmGKB ID PA24673   

mRNA Information


mRNA ID ?NM_005751.4
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS5622.1



Protein Information


      
Protein IDNP_005742.4
Protein NameA kinase (PRKA) anchor protein 9
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 3911  
Uniprot IDQ9HCU9
Ensembl Protein ID ENSP00000353042  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation3869;-
SPhosphorylation3865;-
SPhosphorylation3857;-
SPhosphorylation402
SPhosphorylation390
SPhosphorylation390
SPhosphorylation402
TPhosphorylation730
TPhosphorylation718
TPhosphorylation718
TPhosphorylation730
SPhosphorylation269
SPhosphorylation257
SPhosphorylation257
SPhosphorylation269
TPhosphorylation267
TPhosphorylation255
TPhosphorylation255
TPhosphorylation267

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
808CALM3243NP_005175.2in vitro;in vivo;yeast 2-hybrid12221128   
1192CLIC14188NP_001279.2in vivo12163479   
1453CSNK1D2920NP_001884.2in vitro;in vivo;yeast 2-hybrid12270714   
1454CSNK1E2919NP_001885.1in vitro;yeast 2-hybrid12270714   
5519PPP2R1B4384NP_859050.1in vitro10358086   
5523PPP2R3A9225NP_002709.2in vitro10358086   
5576PRKAR2A1484NP_004148.1in vitro;in vivo1   035   808   611   799   240   
5577PRKAR2B1486NP_002727.2in vitro;in vivo11799244   
5581PRKCE1500NP_005391.1in vitro;in vivo10945988   
7257TSNAX4270NP_005990.1in vitro;in vivo12036294   
9322TRIP105142NP_004231.1in vitro;yeast 2-hybrid15047863   
10460TACC35601NP_006333.1yeast 2-hybrid12015314   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam104953708-3790  PACT_coil_coil
cl111353708-3790  PACT_coil_coil superfamily
COG1627336-624  COG1627
cl19548336-624  DUF515 superfamily
COG1196289-1010  Smc
COG1196175-994  Smc
COG1196200-1001  Smc
TIGR02168289-1018  SMC_prok_B
TIGR02168219-912  SMC_prok_B
COG0419169-761  SbcC
COG11962028-2381  Smc
TIGR02169167-910  SMC_prok_A
TIGR021682041-2444  SMC_prok_B
COG1196167-966  Smc
TIGR02168172-896  SMC_prok_B
COG0419296-896  SbcC
TIGR021682071-2765  SMC_prok_B
COG11962036-2767  Smc
TIGR021681923-2626  SMC_prok_B
TIGR04523173-804  Mplasa_alph_rch
TIGR021691920-2264  SMC_prok_A
COG1196262-654  Smc
COG04191988-2561  SbcC
TIGR04523321-804  Mplasa_alph_rch
COG11961860-2454  Smc
TIGR02169202-1010  SMC_prok_A
TIGR02168178-577  SMC_prok_B
COG11961846-2624  Smc
TIGR02168272-657  SMC_prok_B
PRK03918507-1012  PRK03918
TIGR021681626-2442  SMC_prok_B
COG1196436-777  Smc
TIGR021681923-2642  SMC_prok_B
TIGR021681862-2453  SMC_prok_B
PTZ00121182-896  PTZ00121
pfam02463287-1004  SMC_N
TIGR021681853-2191  SMC_prok_B
TIGR04523300-905  Mplasa_alph_rch
TIGR00618163-822  sbcc
TIGR045231936-2458  Mplasa_alph_rch
COG11962121-2772  Smc
TIGR01612279-1087  235kDa-fam
pfam121281863-2454  DUF3584
pfam12128159-641  DUF3584
TIGR02168167-786  SMC_prok_B
TIGR02168565-898  SMC_prok_B
COG04192207-2767  SbcC
COG11961625-2444  Smc
TIGR02169437-1019  SMC_prok_A
PRK03918169-672  PRK03918
COG11961988-2759  Smc
COG11963068-3326  Smc
TIGR021692144-2500  SMC_prok_A
TIGR021683165-3450  SMC_prok_B
TIGR01612282-1377  235kDa-fam
pfam05622232-778  HOOK
COG11961596-2242  Smc
pfam02463349-1176  SMC_N
COG11963150-3450  Smc
TIGR021683113-3444  SMC_prok_B
PTZ001213078-3450  PTZ00121
TIGR021692198-2461  SMC_prok_A
PRK03918385-912  PRK03918
COG11963091-3425  Smc
COG04191844-2430  SbcC
PTZ00121173-961  PTZ00121
PTZ00121323-805  PTZ00121
TIGR021691988-2320  SMC_prok_A
TIGR021693092-3358  SMC_prok_A
COG43722029-2340  COG4372
PRK02224284-788  PRK02224
PTZ001211884-2402  PTZ00121
TIGR021681861-2241  SMC_prok_B
TIGR045232072-2603  Mplasa_alph_rch
pfam02463501-1205  SMC_N
TIGR02169352-715  SMC_prok_A
TIGR02169323-658  SMC_prok_A
TIGR021692226-2454  SMC_prok_A
pfam12128168-803  DUF3584
pfam05557299-800  MAD
PRK039182070-2646  PRK03918
pfam12128207-790  DUF3584
COG11963091-3425  Smc
pfam05483316-869  SCP-1
PRK02224152-657  PRK02224
TIGR02168493-1129  SMC_prok_B
COG11963069-3375  Smc
PTZ001211808-2454  PTZ00121
PRK03918522-1035  PRK03918
TIGR045232210-2562  Mplasa_alph_rch
TIGR04523342-999  Mplasa_alph_rch
pfam01576163-788  Myosin_tail_1
PLN03229517-804  PLN03229
PRK039181941-2455  PRK03918
COG43721988-2172  COG4372
TIGR00606279-983  rad50
pfam024631990-2772  SMC_N
COG49422068-2277  EnvC
pfam07888220-548  CALCOCO1
PRK05771524-815  PRK05771
PTZ00121321-1019  PTZ00121
COG5022221-819  COG5022
TIGR021683031-3369  SMC_prok_B
TIGR021683131-3448  SMC_prok_B
COG49422004-2253  EnvC
COG1196563-904  Smc
COG1196642-1010  Smc
COG04972095-2422  RecN
COG11963065-3418  Smc
TIGR021681597-2374  SMC_prok_B
COG04193066-3441  SbcC
PRK022241996-2453  PRK02224
COG5022368-800  COG5022
TIGR021691959-2251  SMC_prok_A
pfam131662185-2539  AAA_13
pfam054833104-3440  SCP-1
PTZ00121466-1210  PTZ00121
TIGR031852197-2454  DNA_S_dndD
PRK057712043-2280  PRK05771
pfam039992134-2373  MAP65_ASE1
pfam024631867-2606  SMC_N
pfam056222023-2461  HOOK
pfam121282003-2626  DUF3584
COG04193068-3464  SbcC
pfam05483232-781  SCP-1
COG4942172-422  EnvC
COG12692016-2266  NtpI
TIGR021693232-3450  SMC_prok_A
pfam054831989-2478  SCP-1
TIGR021691980-2261  SMC_prok_A
COG04192145-2751  SbcC
PRK127042144-2265  PRK12704
pfam054831988-2642  SCP-1
COG4942368-629  EnvC
TIGR04523172-418  Mplasa_alph_rch
pfam024632131-2868  SMC_N
PTZ001213078-3433  PTZ00121
pfam05911323-1019  DUF869
TIGR021693072-3450  SMC_prok_A
pfam05483181-796  SCP-1
pfam07888251-619  CALCOCO1
COG2433321-448  COG2433
PRK048632037-2322  mukB
COG5022231-894  COG5022
TIGR00606166-510  rad50
PRK05771696-1020  PRK05771
PRK12704553-750  PRK12704
COG5281159-573  COG5281
COG4913153-760  COG4913
TIGR00606182-599  rad50
COG04192-588  SbcC
pfam05557548-1015  MAD
COG43722199-2376  COG4372
pfam12128488-1010  DUF3584
pfam066372010-2248  PV-1
TIGR00618243-826  sbcc
PHA02562278-451  46
pfam135141996-2424  AAA_27
pfam12128334-913  DUF3584
COG5185350-747  HEC1
PTZ001211988-2431  PTZ00121
TIGR006181919-2561  sbcc
pfam078882024-2332  CALCOCO1
pfam04111680-801  APG6
COG30962004-2262  MukB
PRK11281515-795  PRK11281
TIGR021693070-3328  SMC_prok_A
TIGR018432138-2273  type_I_hlyD
COG11963165-3470  Smc
pfam056223114-3434  HOOK
TIGR021693118-3433  SMC_prok_A
pfam07111165-792  HCR
TIGR021692042-2859  SMC_prok_A
pfam054832032-2415  SCP-1
COG3096177-560  MukB
COG1269540-795  NtpI
TIGR02169147-391  SMC_prok_A
PHA025622151-2381  46
PRK12704608-788  PRK12704
TIGR03185170-457  DNA_S_dndD
PRK127042191-2261  PRK12704
PRK01156167-781  PRK01156
pfam13166226-410  AAA_13
COG5185206-558  HEC1
COG3096209-637  MukB
PRK04863226-560  mukB
PRK00409323-444  PRK00409
TIGR00618159-487  sbcc
TIGR021683068-3247  SMC_prok_B
pfam071112063-2435  HCR
pfam08317208-361  Spc7
COG15792201-2375  COG1579
pfam08317676-805  Spc7
COG51852029-2320  HEC1
pfam101863092-3218  Atg14
pfam121282115-2485  DUF3584
PRK11281202-412  PRK11281
PRK039183112-3447  PRK03918
COG12692141-2389  NtpI
PRK01156285-859  PRK01156
COG4372167-361  COG4372
TIGR00606176-1019  rad50
pfam13514169-813  AAA_27
PRK01156483-1014  PRK01156
COG30962004-2320  MukB
PRK057712151-2424  PRK05771
pfam131662081-2414  AAA_13
PRK048632121-2440  mukB
COG1511507-801  YhgE
COG1269469-698  NtpI
TIGR021693039-3255  SMC_prok_A
pfam13514330-780  AAA_27
TIGR03185520-801  DNA_S_dndD
PRK048632145-2321  mukB
TIGR01069553-739  mutS2
smart007872145-2374  Spc7
pfam09726211-384  Macoilin
PTZ00108608-995  PTZ00108
TIGR021691990-2767  SMC_prok_A
TIGR033192115-2261  RNase_Y
TIGR042112063-2170  SH3_and_anchor
PRK02224431-815  PRK02224
PHA02562289-527  46
TIGR00606588-786  rad50
COG51852067-2384  HEC1
PRK12704311-474  PRK12704
pfam015762024-2450  Myosin_tail_1
PRK039181846-2273  PRK03918
pfam03999222-453  MAP65_ASE1
PRK01156290-598  PRK01156
COG30961862-2182  MukB
TIGR045231862-2268  Mplasa_alph_rch
pfam09726556-771  Macoilin
pfam01496188-429  V_ATPase_I
pfam097263088-3207  Macoilin
PTZ001212122-2775  PTZ00121
pfam015762120-2450  Myosin_tail_1
PRK11281330-737  PRK11281
TIGR04211359-460  SH3_and_anchor
TIGR01069322-437  mutS2
pfam13166492-785  AAA_13


Ontology Information


   
HPRD ID7572
Molecular ClassAdapter molecule
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO