Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 8920673 | 1996 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, western blotting | Up-regulation | - | p16 overexpression would be induced as a brake at G1/S transition through pRB phosphorylation by CDK4 overexpression in advanced colorectal carcinomas. |
| 14562378 | 2003 | Cell line : - Source : Academic Department of Pathology, St. Marks Hospital, London, UK and Department of Pathology, the former West China University of Medical Sciences, China. Sample Type : CRC tumor No. of Sample : 74 Stage : TNM stage I,II,III,IV | Immunohistochemistry,real time RT-PCR,Methylation-specific PCR | Up-regulation | - | �Expression patterns of�CDK4�and p16 may be involved in the development of�colorectal�carcinoma, |
| 16108056 | 2006 | Cell line : - Source : pathology archives at University Hospitals of Cleveland. Sample Type : - No. of Sample : - Stage : TNM stage I,II,III,IV | BAT-RII mutation assay,MSI analysis,Immunohistochemistry, | Up-regulation | - | TGFBR2 mutations in primary colon cancers may be responsible for the increased proliferation and cdk4 expression in these tumors and provide evidence that deregulation of cdk4 is a pathogenic in vivo consequence of TGFBR2 inactivation in primary colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cyclin-dependent kinases |
| Description | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12q13 |
| Start | 58141510 |
| End | 58146304 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4795 |
| OMIM ID | 123829 |
| HGNC ID | HGNC:1773 |
| Unigene ID | Hs.95577 |
| Ensembl ID | - |
| PharmGKB ID | PA102 |
mRNA Information
| mRNA ID | XM_005269074.2 |
|---|---|
| Exon | complement(<4213..>4721) | mRNA Sequence | Download Select all |
| Length |
Protein Information
| Protein ID | XP_005269131.2 |
|---|---|
| Protein Name | cyclin-dependent kinase 4 |
| Molecular Wt. (Da) | 33283 |
| Protein Sequence | Download Select all |
| Length | 300 |
| Uniprot ID | Q9UM47 |
| Ensembl Protein ID | ENSP00000263388 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 172 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro;in vivo | 9244350 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro | 15232106 |
| 1050 | CEBPA | 296 | NP_004355.2 | in vivo | 11684017 |
| 4087 | SMAD2 | 3221 | NP_005892.1 | in vitro | 15241418 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vitro;in vivo | 15241418 |
| 4171 | MCM2 | 303 | NP_004517.2 | in vitro | 15232106 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 9 003 781 112 546 780 000 000 000 000 000 000 000 000 000 |
| 5933 | RBL1 | 312 | NP_002886.2 | in vivo | 12006580 |
| 5981 | RFC1 | 24 | NP_002904.3 | in vivo | 10353443 |
| 5984 | RFC4 | 22 | NP_002907.1 | in vivo | 10353443 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vivo | 15761153 |
| 7917 | BAT3 | 808 | NP_004630.3 | yeast 2-hybrid | 16169070 |
| 9869 | SETDB1 | 6828 | NP_001138887.1 | yeast 2-hybrid | 16169070 |
| 51534 | VTA1 | 9855 | NP_057569.2 | yeast 2-hybrid | 16189514 |
| 79027 | ZNF655 | 11673 | NP_001078837.1 | in vitro;in vivo | 15558030 |
| 79159 | NOL12 | 17537 | NP_077289.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Bladder cancer | hsa05219 |
| Cell cycle | hsa04110 |
| Chronic myeloid leukemia | hsa05220 |
| Glioma | hsa05214 |
| Hepatitis B | hsa05161 |
| HTLV-I infection | hsa05166 |
| Measles | hsa05162 |
| Melanoma | hsa05218 |
| Non-small cell lung cancer | hsa05223 |
| p53 signaling pathway | hsa04115 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Small cell lung cancer | hsa05222 |
| T cell receptor signaling pathway | hsa04660 |
| Tight junction | hsa04530 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07863 | 5-295 | STKc_CDK4 |
| cl21453 | 5-295 | PKc_like superfamily |
| cd07838 | 6-295 | STKc_CDK4_6_like |
| cd07862 | 5-294 | STKc_CDK6 |
| cd07829 | 6-295 | STKc_CDK_like |
| cd07835 | 6-295 | STKc_CDK1_CdkB_like |
| cd07840 | 6-294 | STKc_CDK9_like |
| cd07860 | 6-294 | STKc_CDK2_3 |
| cd07841 | 5-294 | STKc_CDK7 |
| cd07843 | 6-294 | STKc_CDC2L1 |
| cd07836 | 6-294 | STKc_Pho85 |
| cd07845 | 4-294 | STKc_CDK10 |
| cd07861 | 6-295 | STKc_CDK1_euk |
| cd07830 | 6-295 | STKc_MAK_like |
| cd07839 | 5-294 | STKc_CDK5 |
| cd07844 | 6-295 | STKc_PCTAIRE_like |
| cd07837 | 6-294 | STKc_CdkB_plant |
| cd07834 | 5-303 | STKc_MAPK |
| cd07842 | 5-294 | STKc_CDK8_like |
| cd07832 | 5-295 | STKc_CCRK |
| cd07866 | 4-294 | STKc_BUR1 |
| cd05118 | 6-295 | STKc_CMGC |
| cd07852 | 4-295 | STKc_MAPK15-like |
| cd07871 | 6-295 | STKc_PCTAIRE3 |
| cd07833 | 5-295 | STKc_CDKL |
| cd14137 | 5-294 | STKc_GSK3 |
| cd07873 | 6-296 | STKc_PCTAIRE1 |
| cd07865 | 4-294 | STKc_CDK9 |
| cd07855 | 4-297 | STKc_ERK5 |
| cd07864 | 1-295 | STKc_CDK12 |
| cd07870 | 6-295 | STKc_PFTAIRE2 |
| cd07831 | 6-294 | STKc_MOK |
| cd07872 | 6-295 | STKc_PCTAIRE2 |
| cd07849 | 4-295 | STKc_ERK1_2_like |
| cd07851 | 5-303 | STKc_p38 |
| cd07847 | 5-294 | STKc_CDKL1_4 |
| cd07854 | 4-295 | STKc_MAPK4_6 |
| cd07853 | 7-300 | STKc_NLK |
| cd07858 | 3-295 | STKc_TEY_MAPK |
| cd07869 | 6-295 | STKc_PFTAIRE1 |
| cd07856 | 3-295 | STKc_Sty1_Hog1 |
| cd07857 | 5-302 | STKc_MPK1 |
| cd07846 | 5-294 | STKc_CDKL2_3 |
| cd00180 | 12-293 | PKc |
| cd14133 | 6-295 | PKc_DYRK_like |
| cd06606 | 12-295 | STKc_MAPKKK |
| cd07850 | 5-296 | STKc_JNK |
| cd14210 | 5-295 | PKc_DYRK |
| cd05117 | 5-292 | STKc_CAMK |
| cd07880 | 4-303 | STKc_p38gamma |
| cd14014 | 5-290 | STKc_PknB_like |
| cd14002 | 5-295 | STKc_STK36 |
| cd07859 | 5-294 | STKc_TDY_MAPK |
| cd07867 | 11-295 | STKc_CDC2L6 |
| cd07868 | 11-295 | STKc_CDK8 |
| cd07878 | 5-303 | STKc_p38beta |
| cd07877 | 5-303 | STKc_p38alpha |
| cd14132 | 4-294 | STKc_CK2_alpha |
| cd07879 | 5-303 | STKc_p38delta |
| cd07848 | 4-292 | STKc_CDKL5 |
| cd14008 | 12-295 | STKc_LKB1_CaMKK |
| cd14003 | 5-292 | STKc_AMPK-like |
| cd07876 | 5-296 | STKc_JNK2 |
| cd07874 | 5-296 | STKc_JNK3 |
| cd08215 | 5-295 | STKc_Nek |
| cd14009 | 12-285 | STKc_ATG1_ULK_like |
| cd14212 | 6-238 | PKc_YAK1 |
| cd13999 | 12-243 | STKc_MAP3K-like |
| cd14226 | 5-299 | PKc_DYRK1 |
| cd14136 | 4-295 | STKc_SRPK |
| cd14098 | 5-294 | STKc_Rad53_Cds1 |
| cd05122 | 6-295 | PKc_STE |
| cd07875 | 5-296 | STKc_JNK1 |
| cd06627 | 11-295 | STKc_Cdc7_like |
| cd14007 | 12-295 | STKc_Aurora |
| cd08530 | 5-293 | STKc_CNK2-like |
| cd13994 | 12-290 | STKc_HAL4_like |
| cd08217 | 6-295 | STKc_Nek2 |
| cd05123 | 12-289 | STKc_AGC |
| cd14134 | 3-295 | PKc_CLK |
| cd14225 | 5-295 | PKc_DYRK4 |
| cd06632 | 12-295 | STKc_MEKK1_plant |
| cd14224 | 5-295 | PKc_DYRK2_3 |
| cd14019 | 6-295 | STKc_Cdc7 |
| cd14010 | 6-294 | STKc_ULK4 |
| cd06614 | 6-295 | STKc_PAK |
| cd13996 | 3-208 | STKc_EIF2AK |
| cd00192 | 11-208 | PTKc |
| cd13993 | 5-212 | STKc_Pat1_like |
| cd14081 | 6-295 | STKc_BRSK1_2 |
| cd14069 | 6-295 | STKc_Chk1 |
| cd06628 | 10-295 | STKc_Byr2_like |
| cd14211 | 6-295 | STKc_HIPK |
| cd06629 | 12-295 | STKc_Bck1_like |
| cd06630 | 12-292 | STKc_MEKK1 |
| cd06623 | 7-207 | PKc_MAPKK_plant_like |
| cd14135 | 5-295 | STKc_PRP4 |
| cd14080 | 6-295 | STKc_TSSK-like |
| cd06612 | 6-212 | STKc_MST1_2 |
| cd14046 | 4-292 | STKc_EIF2AK4_GCN2_rpt2 |
| cd06625 | 12-243 | STKc_MEKK3_like |
| cd14077 | 6-201 | STKc_Kin1_2 |
| cd14093 | 5-295 | STKc_PhKG |
| cd14119 | 12-295 | STKc_LKB1 |
| cd08529 | 6-295 | STKc_FA2-like |
| cd13997 | 5-293 | PKc_Wee1_like |
| cd05579 | 12-249 | STKc_MAST_like |
| cd08224 | 5-216 | STKc_Nek6_7 |
| cd14216 | 4-295 | STKc_SRPK1 |
| cd14096 | 5-295 | STKc_RCK1-like |
| cd05581 | 11-229 | STKc_PDK1 |
| cd14663 | 5-203 | STKc_SnRK3 |
| cd14082 | 12-203 | STKc_PKD |
| cd14161 | 5-204 | STKc_NUAK2 |
| cd05609 | 6-241 | STKc_MAST |
| cd06626 | 12-207 | STKc_MEKK4 |
| cd13985 | 5-218 | STKc_GAK_like |
| cd14079 | 12-295 | STKc_AMPK_alpha |
| cd14181 | 5-295 | STKc_PhKG2 |
| cd14086 | 4-295 | STKc_CaMKII |
| cd14006 | 12-203 | STKc_MLCK-like |
| cd05578 | 12-295 | STKc_Yank1 |
| cd05611 | 11-286 | STKc_Rim15_like |
| cd14084 | 12-295 | STKc_Chk2 |
| cd06609 | 4-212 | STKc_MST3_like |
| cd06624 | 12-295 | STKc_ASK |
| cd14103 | 12-295 | STKc_MLCK |
| cd14229 | 6-235 | STKc_HIPK3 |
| cd14218 | 5-295 | STKc_SRPK3 |
| cd14073 | 4-203 | STKc_NUAK |
| cd06631 | 12-295 | STKc_YSK4 |
| cd14131 | 5-295 | PKc_Mps1 |
| cd06653 | 12-243 | STKc_MEKK3_like_u1 |
| cd06647 | 5-212 | STKc_PAK_I |
| cd06613 | 6-212 | STKc_MAP4K3_like |
| cd06611 | 3-212 | STKc_SLK_like |
| cd14083 | 3-203 | STKc_CaMKI |
| cd06648 | 11-295 | STKc_PAK_II |
| cd06605 | 7-299 | PKc_MAPKK |
| cd14121 | 12-285 | STKc_ULK3 |
| cd14095 | 5-292 | STKc_DCKL |
| cd14201 | 12-221 | STKc_ULK2 |
| cd08222 | 5-295 | STKc_Nek11 |
| cd14092 | 51-298 | STKc_MSK_C |
| cd14085 | 3-301 | STKc_CaMKIV |
| cd14120 | 12-203 | STKc_ULK1_2-like |
| cd14004 | 6-295 | STKc_PASK |
| cd14074 | 12-295 | STKc_SNRK |
| cd14202 | 12-295 | STKc_ULK1 |
| cd14228 | 3-235 | STKc_HIPK1 |
| cd06607 | 5-218 | STKc_TAO |
| cd06633 | 11-218 | STKc_TAO3 |
| cd14227 | 3-235 | STKc_HIPK2 |
| cd14214 | 5-295 | PKc_CLK3 |
| cd13986 | 5-292 | STKc_16 |
| cd05572 | 12-230 | STKc_cGK |
| cd14166 | 12-298 | STKc_CaMKI_gamma |
| cd14058 | 12-280 | STKc_TAK1 |
| cd13983 | 11-235 | STKc_WNK |
| cd14005 | 5-295 | STKc_PIM |
| cd14106 | 11-203 | STKc_DRAK |
| cd14012 | 23-294 | PK_eIF2AK_GCN2_rpt1 |
| cd06608 | 3-215 | STKc_myosinIII_N_like |
| cd13982 | 11-292 | STKc_IRE1 |
| cd14094 | 6-299 | STKc_CASK |
| cd06652 | 12-243 | STKc_MEKK2 |
| cd14118 | 11-285 | STKc_CAMKK |
| cd13990 | 5-294 | STKc_TLK |
| cd13979 | 10-216 | STKc_Mos |
| cd05612 | 4-244 | STKc_PRKX_like |
| cd06917 | 4-216 | STKc_NAK1_like |
| cd08528 | 6-214 | STKc_Nek10 |
| cd06655 | 4-214 | STKc_PAK2 |
| cd14217 | 4-295 | STKc_SRPK2 |
| cd05573 | 4-241 | STKc_ROCK_NDR_like |
| cd14047 | 6-208 | STKc_EIF2AK2_PKR |
| cd06656 | 5-214 | STKc_PAK3 |
| cd08220 | 5-283 | STKc_Nek8 |
| cd05580 | 6-207 | STKc_PKA_like |
| cd08228 | 11-207 | STKc_Nek6 |
| cd06654 | 5-214 | STKc_PAK1 |
| cd13989 | 12-206 | STKc_IKK |
| cd08218 | 5-295 | STKc_Nek1 |
| cd08225 | 5-264 | STKc_Nek5 |
| cd14197 | 3-295 | STKc_DRAK1 |
| cd14099 | 5-295 | STKc_PLK |
| cd14066 | 12-231 | STKc_IRAK |
| cd06635 | 6-218 | STKc_TAO1 |
| cd14065 | 12-212 | PKc_LIMK_like |
| cd05041 | 12-208 | PTKc_Fes_like |
| cd06659 | 7-303 | STKc_PAK6 |
| cd06610 | 4-201 | STKc_OSR1_SPAK |
| cd13977 | 5-288 | STKc_PDIK1L |
| cd05584 | 12-234 | STKc_p70S6K |
| cd06644 | 6-212 | STKc_STK10 |
| cd06651 | 12-243 | STKc_MEKK3 |
| cd14213 | 1-295 | PKc_CLK1_4 |
| cd14185 | 6-294 | STKc_DCKL3 |
| cd14167 | 12-295 | STKc_CaMKI_alpha |
| cd08219 | 5-218 | STKc_Nek3 |
| cd14105 | 6-226 | STKc_DAPK |
| cd14052 | 5-293 | PTKc_Wee1_fungi |
| cd06642 | 6-212 | STKc_STK25 |
| cd06641 | 6-212 | STKc_MST3 |
| cd14097 | 6-295 | STKc_STK33 |
| cd06643 | 6-212 | STKc_SLK |
| cd05079 | 9-290 | PTKc_Jak1_rpt2 |
| cd05038 | 9-208 | PTKc_Jak_rpt2 |
| cd14091 | 6-295 | STKc_RSK_C |
| cd14169 | 4-298 | STKc_CaMKI_beta |
| cd06634 | 11-218 | STKc_TAO2 |
| cd05048 | 11-255 | PTKc_Ror |
| cd14196 | 6-226 | STKc_DAPK2 |
| cd14182 | 52-297 | STKc_PhKG1 |
| cd14194 | 6-226 | STKc_DAPK1 |
| cd05032 | 11-207 | PTKc_InsR_like |
| cd14048 | 3-207 | STKc_EIF2AK3_PERK |
| cd05600 | 1-218 | STKc_Sid2p_like |
| cd05084 | 11-210 | PTKc_Fes |
| cd14180 | 12-208 | STKc_MSK2_C |
| cd13978 | 12-212 | STKc_RIP |
| cd14049 | 3-208 | STKc_EIF2AK1_HRI |
| cd14113 | 4-295 | STKc_Trio_C |
| cd14164 | 55-295 | STKc_TSSK6-like |
| cd14198 | 11-295 | STKc_DRAK2 |
| cd14114 | 5-295 | STKc_Twitchin_like |
| cd14162 | 12-212 | STKc_TSSK4-like |
| cd14215 | 5-295 | PKc_CLK2 |
| cd14145 | 12-208 | STKc_MLK1 |
| cd14038 | 12-206 | STKc_IKK_beta |
| cd08229 | 11-217 | STKc_Nek7 |
| cd06621 | 12-201 | PKc_Pek1_like |
| cd14039 | 12-206 | STKc_IKK_alpha |
| cd14089 | 12-216 | STKc_MAPKAPK |
| cd05599 | 6-215 | STKc_NDR_like |
| cd14186 | 12-226 | STKc_PLK4 |
| cd08223 | 5-295 | STKc_Nek4 |
| cd06638 | 6-295 | STKc_myosinIIIA_N |
| cd14192 | 3-295 | STKc_MLCK3 |
| cd14062 | 12-223 | STKc_Raf |
| cd14177 | 6-302 | STKc_RSK4_C |
| cd14148 | 12-208 | STKc_MLK2 |
| cd06650 | 6-278 | PKc_MEK1 |
| cd05044 | 12-206 | PTKc_c-ros |
| cd14199 | 4-295 | STKc_CaMKK2 |
| cd06636 | 6-215 | STKc_MAP4K4_6_N |
| cd05148 | 11-210 | PTKc_Srm_Brk |
| cd14146 | 12-208 | STKc_MLK4 |
| cd14155 | 12-210 | PKc_TESK |
| cd05060 | 11-208 | PTKc_Syk_like |
| cd06640 | 6-234 | STKc_MST4 |
| cd05050 | 7-208 | PTKc_Musk |
| cd14195 | 6-226 | STKc_DAPK3 |
| cd06620 | 7-251 | PKc_Byr1_like |
| cd14033 | 11-207 | STKc_WNK4 |
| cd06646 | 6-212 | STKc_MAP4K5 |
| cd05053 | 4-208 | PTKc_FGFR |
| cd14200 | 5-285 | STKc_CaMKK1 |
| cd14059 | 12-207 | STKc_MAP3K12_13 |
| cd14205 | 11-208 | PTKc_Jak2_rpt2 |
| cd14075 | 55-201 | STKc_NIM1 |
| cd14168 | 12-203 | STKc_CaMKI_delta |
| cd13987 | 12-204 | STKc_SBK1 |
| cd14172 | 119-295 | STKc_MAPKAPK3 |
| cd14193 | 12-295 | STKc_MLCK4 |
| cd14179 | 52-284 | STKc_MSK1_C |
| cd06639 | 3-207 | STKc_myosinIIIB_N |
| cd14011 | 55-218 | PK_SCY1_like |
| cd14190 | 12-227 | STKc_MLCK2 |
| cd14147 | 12-283 | STKc_MLK3 |
| cd05598 | 4-226 | STKc_LATS |
| cd14108 | 3-203 | STKc_SPEG_rpt1 |
| cd14050 | 6-201 | PKc_Myt1 |
| cd08221 | 112-214 | STKc_Nek9 |
| cd14170 | 12-303 | STKc_MAPKAPK2 |
| cd05059 | 66-208 | PTKc_Tec_like |
| cd05112 | 9-208 | PTKc_Itk |
| cd06658 | 11-295 | STKc_PAK5 |
| cd06649 | 6-278 | PKc_MEK2 |
| cd14036 | 12-212 | STKc_GAK |
| cd05570 | 127-283 | STKc_PKC |
| cd14076 | 12-295 | STKc_Kin4 |
| cd14183 | 3-298 | STKc_DCKL1 |
| cd14175 | 12-303 | STKc_RSK1_C |
| cd14071 | 55-295 | STKc_SIK |
| cd14116 | 12-226 | STKc_Aurora-A |
| cd05091 | 1-255 | PTKc_Ror2 |
| cd05605 | 99-214 | STKc_GRK4_like |
| cd05061 | 11-207 | PTKc_InsR |
| cd14184 | 56-294 | STKc_DCKL2 |
| cd05057 | 4-212 | PTKc_EGFR_like |
| cd05577 | 99-214 | STKc_GRK |
| cd14072 | 5-203 | STKc_MARK |
| cd14178 | 3-295 | STKc_RSK3_C |
| cd14176 | 3-299 | STKc_RSK2_C |
| cd13988 | 12-204 | STKc_TBK1 |
| cd05040 | 11-242 | PTKc_Ack_like |
| cd14090 | 6-292 | STKc_Mnk |
| cd14061 | 12-207 | STKc_MLK |
| cd05056 | 1-226 | PTKc_FAK |
| cd14017 | 5-165 | STKc_TTBK |
| cd14056 | 11-288 | STKc_TGFbR_I |
| cd14087 | 4-295 | STKc_PSKH1 |
| cd05098 | 67-208 | PTKc_FGFR1 |
| cd05592 | 127-223 | STKc_nPKC_theta_like |
| cd05052 | 12-207 | PTKc_Abl |
| cd05101 | 67-208 | PTKc_FGFR2 |
| cd14191 | 6-226 | STKc_MLCK1 |
| cd13998 | 12-210 | STKc_TGFbR-like |
| cd05034 | 12-208 | PTKc_Src_like |
| cd14032 | 11-207 | STKc_WNK2_like |
| cd05619 | 12-226 | STKc_nPKC_theta |
| cd05049 | 11-220 | PTKc_Trk |
| cd06617 | 7-207 | PKc_MKK3_6 |
| cd06637 | 6-215 | STKc_TNIK |
| cd14031 | 11-207 | STKc_WNK3 |
| cd05099 | 54-208 | PTKc_FGFR4 |
| cd14104 | 5-229 | STKc_Titin |
| cd05081 | 9-208 | PTKc_Jak3_rpt2 |
| cd05036 | 12-208 | PTKc_ALK_LTK |
| cd14189 | 12-295 | STKc_PLK3 |
| cd06645 | 6-295 | STKc_MAP4K3 |
| cd05039 | 10-208 | PTKc_Csk_like |
| cd14000 | 12-240 | STKc_LRRK |
| cd05574 | 4-218 | STKc_phototropin_like |
| cd14150 | 12-207 | STKc_A-Raf |
| cd14101 | 12-207 | STKc_PIM2 |
| cd05100 | 67-208 | PTKc_FGFR3 |
| cd14037 | 15-202 | STKc_NAK_like |
| cd05046 | 55-208 | PTK_CCK4 |
| cd06615 | 6-256 | PKc_MEK |
| cd14078 | 5-295 | STKc_MELK |
| cd14013 | 106-295 | STKc_SNT7_plant |
| cd05632 | 99-219 | STKc_GRK5 |
| cd05601 | 131-226 | STKc_CRIK |
| cd05074 | 12-210 | PTKc_Tyro3 |
| cd14209 | 6-230 | STKc_PKA |
| cd05571 | 128-284 | STKc_PKB |
| cd14664 | 12-207 | STK_BAK1_like |
| cd05603 | 12-299 | STKc_SGK2 |
| cd05607 | 99-207 | STKc_GRK7 |
| cd14030 | 11-207 | STKc_WNK1 |
| cd05586 | 12-242 | STKc_Sck1_like |
| cd05085 | 12-208 | PTKc_Fer |
| cd14165 | 12-207 | STKc_TSSK1_2-like |
| cd05575 | 128-214 | STKc_SGK |
| cd14154 | 12-256 | STKc_LIMK |
| cd14174 | 6-296 | STKc_Mnk1 |
| cd14111 | 121-234 | STKc_SPEG_rpt2 |
| cd14060 | 13-216 | STKc_MLTK |
| cd05035 | 12-210 | PTKc_TAM |
| cd05095 | 54-251 | PTKc_DDR2 |
| cd14016 | 5-165 | STKc_CK1 |
| cd05097 | 54-208 | PTKc_DDR_like |
| cd14187 | 121-214 | STKc_PLK1 |
| cd05604 | 12-214 | STKc_SGK3 |
| cd05092 | 11-220 | PTKc_TrkA |
| cd13995 | 122-295 | STKc_MAP3K8 |
| cd05595 | 12-243 | STKc_PKB_beta |
| cd05589 | 127-230 | STKc_PKN |
| cd05630 | 127-207 | STKc_GRK6 |
| cd05090 | 11-255 | PTKc_Ror1 |
| cd14107 | 4-203 | STKc_obscurin_rpt1 |
| cd14665 | 5-208 | STKc_SnRK2-3 |
| cd14110 | 3-201 | STKc_obscurin_rpt2 |
| cd05631 | 99-222 | STKc_GRK4 |
| cd14156 | 52-212 | PKc_LIMK_like_unk |
| cd14088 | 63-221 | STKc_CaMK_like |
| cd05582 | 12-207 | STKc_RSK_N |
| cd14117 | 6-295 | STKc_Aurora-B_like |
| cd05075 | 12-210 | PTKc_Axl |
| cd14109 | 58-295 | PK_Unc-89_rpt1 |
| cd05042 | 65-208 | PTKc_Aatyk |
| cd05058 | 12-210 | PTKc_Met_Ron |
| cd06616 | 11-234 | PKc_MKK4 |
| cd05620 | 123-223 | STKc_nPKC_delta |
| cd05587 | 127-228 | STKc_cPKC |
| cd06657 | 11-297 | STKc_PAK4 |
| cd05067 | 9-207 | PTKc_Lck_Blk |
| cd14662 | 5-294 | STKc_SnRK2 |
| cd14207 | 116-208 | PTKc_VEGFR1 |
| cd14020 | 55-208 | STKc_KIS |
| cd05627 | 6-235 | STKc_NDR2 |
| cd05055 | 68-208 | PTKc_PDGFR |
| cd05065 | 12-239 | PTKc_EphR_B |
| cd06622 | 7-207 | PKc_PBS2_like |
| cd05591 | 128-230 | STKc_nPKC_epsilon |
| cd05602 | 12-228 | STKc_SGK1 |
| cd05590 | 12-230 | STKc_nPKC_eta |
| cd05113 | 68-208 | PTKc_Btk_Bmx |
| cd05083 | 10-208 | PTKc_Chk |
| cd14222 | 54-207 | STKc_LIMK2 |
| cd14163 | 6-208 | STKc_TSSK3-like |
| cd05108 | 4-212 | PTKc_EGFR |
| cd05045 | 63-207 | PTKc_RET |
| cd05054 | 68-208 | PTKc_VEGFR |
| cd14158 | 12-230 | STKc_IRAK4 |
| cd05610 | 9-296 | STKc_MASTL |
| cd14204 | 12-210 | PTKc_Mer |
| cd14151 | 12-255 | STKc_B-Raf |
| cd05616 | 127-223 | STKc_cPKC_beta |
| cd13968 | 12-160 | PKc_like |
| cd05608 | 110-211 | STKc_GRK1 |
| cd05628 | 6-235 | STKc_NDR1 |
| cd05033 | 9-239 | PTKc_EphR |
| cd05080 | 11-210 | PTKc_Tyk2_rpt2 |
| cd05593 | 123-295 | STKc_PKB_gamma |
| cd05107 | 113-208 | PTKc_PDGFR_beta |
| cd14027 | 15-211 | STKc_RIP1 |
| cd14149 | 10-207 | STKc_C-Raf |
| cd05068 | 55-207 | PTKc_Frk_like |
| cd06619 | 125-207 | PKc_MKK5 |
| cd05106 | 105-208 | PTKc_CSF-1R |
| cd14070 | 68-201 | STKc_HUNK |
| cd05614 | 6-286 | STKc_MSK2_N |
| cd14171 | 68-295 | STKc_MAPKAPK5 |
| cd14188 | 117-295 | STKc_PLK2 |
| cd14040 | 5-223 | STKc_TLK1 |
| cd14041 | 5-223 | STKc_TLK2 |
| cd14112 | 3-203 | STKc_Unc-89_rpt2 |
| cd05606 | 127-209 | STKc_beta_ARK |
| cd05585 | 123-214 | STKc_YPK1_like |
| cd05115 | 11-212 | PTKc_Zap-70 |
| cd05094 | 11-219 | PTKc_TrkC |
| cd05615 | 127-228 | STKc_cPKC_alpha |
| cd05105 | 116-208 | PTKc_PDGFR_alpha |
| cd14159 | 12-213 | STKc_IRAK1 |
| cd05102 | 116-208 | PTKc_VEGFR3 |
| cd13991 | 12-286 | STKc_NIK |
| cd05096 | 54-257 | PTKc_DDR1 |
| cd14206 | 11-208 | PTKc_Aatyk3 |
| cd14064 | 12-208 | PKc_TNNI3K |
| cd05103 | 116-208 | PTKc_VEGFR2 |
| cd05596 | 128-228 | STKc_ROCK |
| cd14144 | 127-288 | STKc_BMPR1 |
| cd14221 | 12-229 | STKc_LIMK1 |
| cd05116 | 11-212 | PTKc_Syk |
| cd14053 | 126-210 | STKc_ACVR2 |
| cd13975 | 11-204 | PKc_Dusty |
| cd06618 | 7-201 | PKc_MKK7 |
| cd05093 | 11-208 | PTKc_TrkB |
| cd14055 | 12-210 | STKc_TGFbR2_like |
| cd14173 | 55-295 | STKc_Mnk2 |
| cd05066 | 12-207 | PTKc_EphR_A |
| cd05082 | 12-212 | PTKc_Csk |
| cd05623 | 95-228 | STKc_MRCK_alpha |
| cd05597 | 99-226 | STKc_DMPK_like |
| cd14054 | 12-210 | STKc_BMPR2_AMHR2 |
| cd05051 | 55-257 | PTKc_DDR |
| cd13980 | 123-300 | STKc_Vps15 |
| cd05073 | 11-242 | PTKc_Hck |
| cd05613 | 6-243 | STKc_MSK1_N |
| cd05583 | 128-207 | STKc_MSK_N |
| cd05594 | 123-243 | STKc_PKB_alpha |
| cd05633 | 12-209 | STKc_GRK3 |
| cd14142 | 136-288 | STKc_ACVR1_ALK1 |
| cd05072 | 9-221 | PTKc_Lyn |
| cd05114 | 68-208 | PTKc_Tec_Rlk |
| cd05624 | 95-228 | STKc_MRCK_beta |
| cd05070 | 50-210 | PTKc_Fyn |
| cd05062 | 11-207 | PTKc_IGF-1R |
| cd14068 | 12-283 | STKc_LRRK2 |
| cd05104 | 94-208 | PTKc_Kit |
| cd05626 | 4-214 | STKc_LATS2 |
| cd14001 | 56-286 | PKc_TOPK |
| cd14223 | 12-222 | STKc_GRK2 |
| cd14203 | 50-207 | PTKc_Src_Fyn_like |
| cd05629 | 121-226 | STKc_NDR_like_fungal |
| cd14100 | 12-207 | STKc_PIM1 |
| cd14102 | 6-207 | STKc_PIM3 |
| cd05625 | 4-235 | STKc_LATS1 |
| cd14067 | 123-235 | STKc_LRRK1 |
| cd05063 | 12-242 | PTKc_EphR_A2 |
| cd05617 | 6-214 | STKc_aPKC_zeta |
| cd05618 | 64-214 | STKc_aPKC_iota |
| COG3642 | 53-164 | Bud32 |
| TIGR03724 | 53-164 | arch_bud32 |
| smart00220 | 6-295 | S_TKc |
| PLN00009 | 5-302 | PLN00009 |
| pfam00069 | 6-295 | Pkinase |
| PTZ00024 | 3-298 | PTZ00024 |
| COG0515 | 6-296 | SPS1 |
| PTZ00036 | 12-290 | PTZ00036 |
| smart00221 | 11-208 | STYKc |
| smart00219 | 11-208 | TyrKc |
| pfam07714 | 11-201 | Pkinase_Tyr |
| PHA03209 | 6-286 | PHA03209 |
| PLN00034 | 4-295 | PLN00034 |
| PHA03212 | 53-293 | PHA03212 |
| PHA03211 | 52-206 | PHA03211 |
| PHA03207 | 55-286 | PHA03207 |
| TIGR03903 | 28-245 | TOMM_kin_cyc |
| PTZ00267 | 24-293 | PTZ00267 |
| PTZ00263 | 12-214 | PTZ00263 |
| PTZ00266 | 4-223 | PTZ00266 |
| PLN03225 | 109-294 | PLN03225 |
| PTZ00284 | 128-297 | PTZ00284 |
| PTZ00283 | 120-290 | PTZ00283 |
| PHA03210 | 56-290 | PHA03210 |
| PRK13184 | 5-211 | pknD |
| PTZ00426 | 128-217 | PTZ00426 |
| PHA03390 | 67-201 | pk1 |
| PLN03224 | 105-214 | PLN03224 |
| COG0478 | 11-159 | RIO2 |
Ontology Information
| HPRD ID | 1246 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P11802 | DB09073 | Palbociclib | SmallMoleculeDrug |