Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDK6 | 1021 | Cyclin-dependent kinase 6  | 7 | PLSTIRE  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23197571    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 10 CRC and breast cancer and 10 healthy control Stage : - | Whole-genome analyses | Amplification | - | In all patients, structural alterations such as chromosomal copy number changes and rearrangements, including amplification that were not present in plasma DNA from healthy subjects were identified. |
| 17848589    | 2007 | Cell line : - Source : Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : - No. of Sample : - Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistoc | Down-regulation | 0.529 | - |
| 20736363    | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Assaying apoptosis, mitosis, and crypt size in vivo, Assaying proliferation in vivo, Immunohistochem | Up-regulation | - | Cyclin D-CDK4/6 complexes are required for the efficient proliferation of cells. Cyclin D2 is upregulated immediately following Apc loss, which corresponded with a significant increase in cyclin-dependent kinase 4 (CDK4) and hyperphosphorylated Rb levels. |
| 22252525    | 2012 | Cell line : SW 480, LoVo Source : ATCC Sample Type : - No. of Sample : - Stage : - | Cell proliferation assays,Colony forming efficiency in soft agar, Serum starvation. | Up-regulation | - | PAK1 knock-down downregulated c-Jun amino terminal kinases (JNK) activity and the levels of cyclinD1, CDK4/6. PAK1 expression was increased with colorectal cancer (CRC) progression through the adenoma to carcinoma sequence. PAK1 knockdown decreased proliferation and delayed the G1/S cell-cycle transition, and increased apoptosis in vivo and in vitro. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Cyclin-dependent kinases |
| Description | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]   |
| Chromosome | 7 |
| Location | 7q21-q22 |
| Start | 92604921   |
| End | 92836627   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 231707   |
| OMIM ID | 603368    |
| HGNC ID | HGNC:1777    |
| Unigene ID | Hs.119882     |
| Ensembl ID | ENSG00000105810    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001145306.1 |
|---|---|
| Exon | join(1..150,2938..3537,61797..61932,110835..111002, 165093..165202,213542..213592,218421..218556, 221342..231707)   | mRNA Sequence |    Download   Select all |
| Length | 11733   |
CDS Information
| Location | join(3305..3537,61797..61932,110835..111002, 165093..165202,213542..213592,218421..218556, 221342..221488) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS5628.1 |    
Protein Information
| Protein ID | NP_001138778.1 |
|---|---|
| Protein Name | Cyclin-dependent kinase 6 |
| Molecular Wt. (Da) | 36807 |
| Protein Sequence |    Download   Select all |
| Length | 326   |
| Uniprot ID | Q13489 |    
| Ensembl Protein ID | ENSP00000263464   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 13;- |
| Y | Phosphorylation | 24;- |
| Y | Phosphorylation | 24;- |
| Y | Phosphorylation | 13;- |
| K | Acetylation | 264 |
| K | Acetylation | 43 |
Enzyme Information
| EC | 2.7.11.22 |    
|---|---|
| Name | cyclin-dependent kinase Bur1 Bur1 Cdk Cak1 Cak1p cdc2 cdc2 kinase Cdc28p CDK cdk-activating kinase Cdk-activating protein kinase cdk1 cdk2 Cdk2 cdk3 cdk4 cdk5 cdk6 cdk7 cdk8 cdk9 cyclin A-activated cdc2 cyclin A-activated cdk2 cyclin D-cdk6 kinase cyclin D-dependent kinase cyclin E kinase cyclin-A associated kinase cyclin-dependent kinase 6 cyclin-dependent kinase-2 cyclin-dependent kinase-4 cyclin-dependent protein kinase activating kinase cyk D-type cyclin kinase nclk neuronal cdc2-like kinase PCTAIRE-1 STK25 |
| Class | Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases |
| Sysname | ATP:cyclin phosphotransferase   |
| Substrate | ATP [CPD:C00002]; protein   |
| Product | ADP [CPD:C00008]; phosphoprotein   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 595 |    CCND1 |    1346 |    NP_444284.1 |    in vitro;in vivo |    11   739   795   152   321   000   000   000   000   000   000    |
| 896 |    CCND3 |    452 |    NP_001751.1 |    in vitro;in vivo |    8   114   739   113   601   840   000   000   000   000   000    |
| 1026 |    CDKN1A |    298 |    NP_510867.1 |    in vitro |    15232106    |
| 1029 |    CDKN2A |    2542 |    NP_478102.1 |    in vitro |    9751050    |
| 1032 |    CDKN2D |    2957 |    NP_001791.1 |    in vitro |    97   510   509   751   051    |
| 4171 |    MCM2 |    303 |    NP_004517.2 |    in vitro |    15232106    |
| 5111 |    PCNA |    1456 |    NP_002583.1 |    in vivo |    9667749    |
| 6310 |    ATXN1 |    3333 |    NP_000323.2 |    yeast 2-hybrid |    16713569    |
| 7046 |    TGFBR1 |    1822 |    NP_004603.1 |    in vivo |    15761153    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle |    hsa04110 |    
| Chronic myeloid leukemia |    hsa05220 |    
| Glioma |    hsa05214 |    
| Hepatitis B |    hsa05161 |    
| Measles |    hsa05162 |    
| Melanoma |    hsa05218 |    
| MicroRNAs in cancer |    hsa05206 |    
| Non-small cell lung cancer |    hsa05223 |    
| p53 signaling pathway |    hsa04115 |    
| Pancreatic cancer |    hsa05212 |    
| Pathways in cancer |    hsa05200 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Small cell lung cancer |    hsa05222 |    
| Viral carcinogenesis |    hsa05203 |    
Structure Information
| PDB ID | 1BI7 |
|---|---|
| Resolution | 3.4 |
| Method | X-RAY DIFFRACTION |
| Chains | A   |
| Molecule | CYCLIN-DEPENDENT KINASE 6   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07862 | 11-300  | STKc_CDK6 |
| cl21453 | 11-300  | PKc_like superfamily |
| cd07838 | 13-300  | STKc_CDK4_6_like |
| cd07863 | 12-300  | STKc_CDK4 |
| cd07829 | 13-300  | STKc_CDK_like |
| cd07835 | 13-300  | STKc_CDK1_CdkB_like |
| cd07860 | 13-300  | STKc_CDK2_3 |
| cd07840 | 13-300  | STKc_CDK9_like |
| cd07843 | 7-300  | STKc_CDC2L1 |
| cd07861 | 13-300  | STKc_CDK1_euk |
| cd07836 | 12-300  | STKc_Pho85 |
| cd07839 | 12-300  | STKc_CDK5 |
| cd07832 | 12-300  | STKc_CCRK |
| cd07837 | 13-300  | STKc_CdkB_plant |
| cd07845 | 5-302  | STKc_CDK10 |
| cd07844 | 13-300  | STKc_PCTAIRE_like |
| cd07841 | 12-300  | STKc_CDK7 |
| cd07830 | 13-300  | STKc_MAK_like |
| cd07834 | 13-303  | STKc_MAPK |
| cd07866 | 7-300  | STKc_BUR1 |
| cd07833 | 11-300  | STKc_CDKL |
| cd05118 | 13-300  | STKc_CMGC |
| cd07852 | 11-302  | STKc_MAPK15-like |
| cd07842 | 12-300  | STKc_CDK8_like |
| cd07865 | 7-300  | STKc_CDK9 |
| cd14137 | 12-303  | STKc_GSK3 |
| cd07871 | 11-300  | STKc_PCTAIRE3 |
| cd07873 | 11-305  | STKc_PCTAIRE1 |
| cd07870 | 13-300  | STKc_PFTAIRE2 |
| cd07847 | 11-300  | STKc_CDKL1_4 |
| cd07831 | 13-300  | STKc_MOK |
| cd07864 | 12-299  | STKc_CDK12 |
| cd07855 | 10-311  | STKc_ERK5 |
| cd07849 | 10-301  | STKc_ERK1_2_like |
| cd07869 | 8-303  | STKc_PFTAIRE1 |
| cd07872 | 11-303  | STKc_PCTAIRE2 |
| cd07857 | 13-299  | STKc_MPK1 |
| cd07846 | 11-300  | STKc_CDKL2_3 |
| cd07851 | 10-300  | STKc_p38 |
| cd07858 | 10-303  | STKc_TEY_MAPK |
| cd07854 | 12-302  | STKc_MAPK4_6 |
| cd14133 | 13-300  | PKc_DYRK_like |
| cd14132 | 12-301  | STKc_CK2_alpha |
| cd05117 | 12-298  | STKc_CAMK |
| cd07853 | 19-302  | STKc_NLK |
| cd06606 | 12-300  | STKc_MAPKKK |
| cd05122 | 13-300  | PKc_STE |
| cd14210 | 12-300  | PKc_DYRK |
| cd07880 | 11-316  | STKc_p38gamma |
| cd07848 | 12-300  | STKc_CDKL5 |
| cd07856 | 11-299  | STKc_Sty1_Hog1 |
| cd00180 | 19-298  | PKc |
| cd07879 | 11-308  | STKc_p38delta |
| cd07878 | 11-300  | STKc_p38beta |
| cd07859 | 12-305  | STKc_TDY_MAPK |
| cd14002 | 12-299  | STKc_STK36 |
| cd14014 | 12-295  | STKc_PknB_like |
| cd07877 | 11-300  | STKc_p38alpha |
| cd07850 | 12-299  | STKc_JNK |
| cd08215 | 12-300  | STKc_Nek |
| cd14003 | 12-299  | STKc_AMPK-like |
| cd14008 | 19-300  | STKc_LKB1_CaMKK |
| cd07867 | 18-300  | STKc_CDC2L6 |
| cd06627 | 18-300  | STKc_Cdc7_like |
| cd07868 | 18-300  | STKc_CDK8 |
| cd05123 | 19-300  | STKc_AGC |
| cd14009 | 19-299  | STKc_ATG1_ULK_like |
| cd14212 | 13-300  | PKc_YAK1 |
| cd07876 | 11-299  | STKc_JNK2 |
| cd14007 | 19-301  | STKc_Aurora |
| cd13999 | 19-288  | STKc_MAP3K-like |
| cd07874 | 11-299  | STKc_JNK3 |
| cd06632 | 19-299  | STKc_MEKK1_plant |
| cd13994 | 19-300  | STKc_HAL4_like |
| cd14134 | 10-300  | PKc_CLK |
| cd14226 | 12-301  | PKc_DYRK1 |
| cd07875 | 11-299  | STKc_JNK1 |
| cd06614 | 13-301  | STKc_PAK |
| cd14098 | 12-299  | STKc_Rad53_Cds1 |
| cd05581 | 11-300  | STKc_PDK1 |
| cd06609 | 11-299  | STKc_MST3_like |
| cd05579 | 19-304  | STKc_MAST_like |
| cd14225 | 12-300  | PKc_DYRK4 |
| cd06623 | 14-301  | PKc_MAPKK_plant_like |
| cd08217 | 12-300  | STKc_Nek2 |
| cd06611 | 13-302  | STKc_SLK_like |
| cd14019 | 13-300  | STKc_Cdc7 |
| cd06613 | 12-300  | STKc_MAP4K3_like |
| cd14131 | 12-299  | PKc_Mps1 |
| cd08530 | 12-223  | STKc_CNK2-like |
| cd06626 | 19-299  | STKc_MEKK4 |
| cd14069 | 12-300  | STKc_Chk1 |
| cd00192 | 18-213  | PTKc |
| cd06612 | 11-300  | STKc_MST1_2 |
| cd14224 | 12-299  | PKc_DYRK2_3 |
| cd14006 | 19-299  | STKc_MLCK-like |
| cd05609 | 12-304  | STKc_MAST |
| cd06625 | 19-300  | STKc_MEKK3_like |
| cd14135 | 13-300  | STKc_PRP4 |
| cd14095 | 13-299  | STKc_DCKL |
| cd14081 | 12-300  | STKc_BRSK1_2 |
| cd06629 | 19-299  | STKc_Bck1_like |
| cd08224 | 13-212  | STKc_Nek6_7 |
| cd14663 | 12-208  | STKc_SnRK3 |
| cd14214 | 8-300  | PKc_CLK3 |
| cd06605 | 14-305  | PKc_MAPKK |
| cd14213 | 12-300  | PKc_CLK1_4 |
| cd13993 | 13-291  | STKc_Pat1_like |
| cd13990 | 19-299  | STKc_TLK |
| cd06648 | 18-300  | STKc_PAK_II |
| cd05578 | 19-300  | STKc_Yank1 |
| cd14136 | 13-300  | STKc_SRPK |
| cd14092 | 11-302  | STKc_MSK_C |
| cd08529 | 13-298  | STKc_FA2-like |
| cd14083 | 13-299  | STKc_CaMKI |
| cd14119 | 19-300  | STKc_LKB1 |
| cd06630 | 19-300  | STKc_MEKK1 |
| cd14093 | 57-300  | STKc_PhKG |
| cd14080 | 13-300  | STKc_TSSK-like |
| cd14215 | 11-300  | PKc_CLK2 |
| cd13982 | 18-300  | STKc_IRE1 |
| cd06647 | 10-301  | STKc_PAK_I |
| cd14121 | 19-299  | STKc_ULK3 |
| cd14010 | 13-299  | STKc_ULK4 |
| cd06608 | 13-299  | STKc_myosinIII_N_like |
| cd06628 | 17-299  | STKc_Byr2_like |
| cd06624 | 19-299  | STKc_ASK |
| cd08528 | 12-219  | STKc_Nek10 |
| cd13997 | 13-298  | PKc_Wee1_like |
| cd08222 | 12-299  | STKc_Nek11 |
| cd14099 | 12-300  | STKc_PLK |
| cd14096 | 12-299  | STKc_RCK1-like |
| cd14077 | 13-299  | STKc_Kin1_2 |
| cd06610 | 12-300  | STKc_OSR1_SPAK |
| cd14047 | 8-213  | STKc_EIF2AK2_PKR |
| cd05611 | 18-303  | STKc_Rim15_like |
| cd14167 | 13-299  | STKc_CaMKI_alpha |
| cd13985 | 18-303  | STKc_GAK_like |
| cd14118 | 18-299  | STKc_CAMKK |
| cd13996 | 8-213  | STKc_EIF2AK |
| cd06659 | 18-300  | STKc_PAK6 |
| cd06621 | 19-311  | PKc_Pek1_like |
| cd06631 | 19-299  | STKc_YSK4 |
| cd14046 | 8-297  | STKc_EIF2AK4_GCN2_rpt2 |
| cd14169 | 13-299  | STKc_CaMKI_beta |
| cd14074 | 13-299  | STKc_SNRK |
| cd14185 | 13-299  | STKc_DCKL3 |
| cd14194 | 10-299  | STKc_DAPK1 |
| cd14084 | 19-299  | STKc_Chk2 |
| cd14166 | 19-299  | STKc_CaMKI_gamma |
| cd14120 | 19-299  | STKc_ULK1_2-like |
| cd14201 | 9-301  | STKc_ULK2 |
| cd14079 | 12-300  | STKc_AMPK_alpha |
| cd08228 | 18-212  | STKc_Nek6 |
| cd05573 | 12-303  | STKc_ROCK_NDR_like |
| cd14103 | 19-299  | STKc_MLCK |
| cd06620 | 11-305  | PKc_Byr1_like |
| cd14181 | 11-300  | STKc_PhKG2 |
| cd13986 | 19-303  | STKc_16 |
| cd06644 | 10-299  | STKc_STK10 |
| cd14005 | 12-300  | STKc_PIM |
| cd05572 | 19-302  | STKc_cGK |
| cd14216 | 12-300  | STKc_SRPK1 |
| cd14202 | 19-301  | STKc_ULK1 |
| cd06655 | 11-301  | STKc_PAK2 |
| cd06653 | 19-265  | STKc_MEKK3_like_u1 |
| cd06656 | 11-301  | STKc_PAK3 |
| cd13979 | 15-221  | STKc_Mos |
| cd14085 | 13-310  | STKc_CaMKIV |
| cd08225 | 12-223  | STKc_Nek5 |
| cd14229 | 13-241  | STKc_HIPK3 |
| cd14086 | 11-305  | STKc_CaMKII |
| cd06607 | 11-219  | STKc_TAO |
| cd14105 | 10-299  | STKc_DAPK |
| cd06643 | 13-299  | STKc_SLK |
| cd08218 | 12-223  | STKc_Nek1 |
| cd06633 | 18-217  | STKc_TAO3 |
| cd14196 | 13-299  | STKc_DAPK2 |
| cd14082 | 11-208  | STKc_PKD |
| cd14186 | 11-299  | STKc_PLK4 |
| cd14161 | 11-209  | STKc_NUAK2 |
| cd14004 | 13-300  | STKc_PASK |
| cd14094 | 10-305  | STKc_CASK |
| cd14211 | 13-240  | STKc_HIPK |
| cd14199 | 12-301  | STKc_CaMKK2 |
| cd06641 | 10-217  | STKc_MST3 |
| cd14106 | 18-300  | STKc_DRAK |
| cd14073 | 11-208  | STKc_NUAK |
| cd06654 | 11-301  | STKc_PAK1 |
| cd14052 | 13-211  | PTKc_Wee1_fungi |
| cd14198 | 18-300  | STKc_DRAK2 |
| cd14227 | 1-299  | STKc_HIPK2 |
| cd14116 | 11-299  | STKc_Aurora-A |
| cd08219 | 12-223  | STKc_Nek3 |
| cd06635 | 18-217  | STKc_TAO1 |
| cd08220 | 13-298  | STKc_Nek8 |
| cd06652 | 19-217  | STKc_MEKK2 |
| cd14180 | 11-302  | STKc_MSK2_C |
| cd06634 | 18-217  | STKc_TAO2 |
| cd06638 | 13-299  | STKc_myosinIIIA_N |
| cd05612 | 11-245  | STKc_PRKX_like |
| cd14228 | 6-240  | STKc_HIPK1 |
| cd14164 | 19-212  | STKc_TSSK6-like |
| cd06917 | 19-291  | STKc_NAK1_like |
| cd05580 | 11-303  | STKc_PKA_like |
| cd08229 | 8-221  | STKc_Nek7 |
| cd14195 | 10-301  | STKc_DAPK3 |
| cd06651 | 19-301  | STKc_MEKK3 |
| cd14197 | 18-300  | STKc_DRAK1 |
| cd14182 | 57-301  | STKc_PhKG1 |
| cd06642 | 19-299  | STKc_STK25 |
| cd14184 | 11-299  | STKc_DCKL2 |
| cd14058 | 19-290  | STKc_TAK1 |
| cd05570 | 19-307  | STKc_PKC |
| cd14036 | 19-217  | STKc_GAK |
| cd06650 | 10-304  | PKc_MEK1 |
| cd14218 | 12-300  | STKc_SRPK3 |
| cd14192 | 19-300  | STKc_MLCK3 |
| cd14066 | 19-288  | STKc_IRAK |
| cd14183 | 11-302  | STKc_DCKL1 |
| cd05048 | 18-213  | PTKc_Ror |
| cd14050 | 11-206  | PKc_Myt1 |
| cd05038 | 16-236  | PTKc_Jak_rpt2 |
| cd05577 | 19-303  | STKc_GRK |
| cd05041 | 19-213  | PTKc_Fes_like |
| cd08223 | 12-299  | STKc_Nek4 |
| cd05599 | 11-304  | STKc_NDR_like |
| cd14087 | 12-299  | STKc_PSKH1 |
| cd05060 | 18-231  | PTKc_Syk_like |
| cd14091 | 12-318  | STKc_RSK_C |
| cd05079 | 16-303  | PTKc_Jak1_rpt2 |
| cd14090 | 13-299  | STKc_Mnk |
| cd14097 | 13-299  | STKc_STK33 |
| cd13987 | 19-209  | STKc_SBK1 |
| cd06640 | 19-308  | STKc_MST4 |
| cd14117 | 13-317  | STKc_Aurora-B_like |
| cd13983 | 18-212  | STKc_WNK |
| cd14059 | 19-212  | STKc_MAP3K12_13 |
| cd06658 | 18-301  | STKc_PAK5 |
| cd05053 | 19-213  | PTKc_FGFR |
| cd05584 | 19-302  | STKc_p70S6K |
| cd05619 | 19-304  | STKc_nPKC_theta |
| cd14076 | 19-299  | STKc_Kin4 |
| cd14190 | 19-300  | STKc_MLCK2 |
| cd14049 | 8-213  | STKc_EIF2AK1_HRI |
| cd14193 | 19-299  | STKc_MLCK4 |
| cd06639 | 13-301  | STKc_myosinIIIB_N |
| cd05059 | 16-213  | PTKc_Tec_like |
| cd05582 | 19-238  | STKc_RSK_N |
| cd05600 | 12-325  | STKc_Sid2p_like |
| cd14072 | 12-208  | STKc_MARK |
| cd14107 | 13-300  | STKc_obscurin_rpt1 |
| cd13977 | 12-292  | STKc_PDIK1L |
| cd14012 | 73-299  | PK_eIF2AK_GCN2_rpt1 |
| cd05084 | 18-215  | PTKc_Fes |
| cd05598 | 12-304  | STKc_LATS |
| cd14200 | 12-299  | STKc_CaMKK1 |
| cd14145 | 19-221  | STKc_MLK1 |
| cd14205 | 18-213  | PTKc_Jak2_rpt2 |
| cd14217 | 10-300  | STKc_SRPK2 |
| cd14168 | 13-307  | STKc_CaMKI_delta |
| cd05050 | 14-213  | PTKc_Musk |
| cd14162 | 19-300  | STKc_TSSK4-like |
| cd05607 | 19-220  | STKc_GRK7 |
| cd14113 | 10-300  | STKc_Trio_C |
| cd14109 | 18-300  | PK_Unc-89_rpt1 |
| cd05112 | 16-213  | PTKc_Itk |
| cd05083 | 11-213  | PTKc_Chk |
| cd05574 | 11-302  | STKc_phototropin_like |
| cd06637 | 13-302  | STKc_TNIK |
| cd14011 | 67-302  | PK_SCY1_like |
| cd06617 | 14-301  | PKc_MKK3_6 |
| cd06657 | 18-300  | STKc_PAK4 |
| cd05583 | 19-303  | STKc_MSK_N |
| cd06636 | 13-217  | STKc_MAP4K4_6_N |
| cd14089 | 19-299  | STKc_MAPKAPK |
| cd06646 | 11-217  | STKc_MAP4K5 |
| cd05040 | 18-303  | PTKc_Ack_like |
| cd05049 | 18-222  | PTKc_Trk |
| cd06649 | 10-304  | PKc_MEK2 |
| cd14071 | 60-206  | STKc_SIK |
| cd05046 | 19-231  | PTK_CCK4 |
| cd13978 | 19-217  | STKc_RIP |
| cd14065 | 19-297  | PKc_LIMK_like |
| cd14013 | 19-300  | STKc_SNT7_plant |
| cd14179 | 19-309  | STKc_MSK1_C |
| cd08221 | 13-300  | STKc_Nek9 |
| cd05032 | 18-212  | PTKc_InsR_like |
| cd14000 | 19-260  | STKc_LRRK |
| cd13989 | 19-211  | STKc_IKK |
| cd14114 | 13-300  | STKc_Twitchin_like |
| cd05613 | 13-303  | STKc_MSK1_N |
| cd05098 | 19-213  | PTKc_FGFR1 |
| cd05585 | 19-316  | STKc_YPK1_like |
| cd05099 | 19-213  | PTKc_FGFR4 |
| cd06645 | 11-217  | STKc_MAP4K3 |
| cd14061 | 19-221  | STKc_MLK |
| cd14146 | 19-221  | STKc_MLK4 |
| cd14020 | 17-300  | STKc_KIS |
| cd14174 | 13-301  | STKc_Mnk1 |
| cd05605 | 104-303  | STKc_GRK4_like |
| cd05091 | 18-244  | PTKc_Ror2 |
| cd14048 | 12-212  | STKc_EIF2AK3_PERK |
| cd05034 | 19-213  | PTKc_Src_like |
| cd05101 | 19-213  | PTKc_FGFR2 |
| cd05148 | 8-215  | PTKc_Srm_Brk |
| cd14108 | 13-300  | STKc_SPEG_rpt1 |
| cd05631 | 19-310  | STKc_GRK4 |
| cd05614 | 13-304  | STKc_MSK2_N |
| cd05601 | 136-316  | STKc_CRIK |
| cd05085 | 19-213  | PTKc_Fer |
| cd14038 | 19-211  | STKc_IKK_beta |
| cd14033 | 18-212  | STKc_WNK4 |
| cd05604 | 19-219  | STKc_SGK3 |
| cd05571 | 133-325  | STKc_PKB |
| cd05054 | 19-213  | PTKc_VEGFR |
| cd06622 | 14-305  | PKc_PBS2_like |
| cd05603 | 19-228  | STKc_SGK2 |
| cd06615 | 129-301  | PKc_MEK |
| cd05590 | 19-316  | STKc_nPKC_eta |
| cd13995 | 19-297  | STKc_MAP3K8 |
| cd05090 | 18-244  | PTKc_Ror1 |
| cd14111 | 13-219  | STKc_SPEG_rpt2 |
| cd05056 | 19-231  | PTKc_FAK |
| cd13998 | 19-215  | STKc_TGFbR-like |
| cd06619 | 11-299  | PKc_MKK5 |
| cd05630 | 19-303  | STKc_GRK6 |
| cd14075 | 60-233  | STKc_NIM1 |
| cd05100 | 19-232  | PTKc_FGFR3 |
| cd14154 | 19-314  | STKc_LIMK |
| cd14148 | 19-228  | STKc_MLK2 |
| cd05039 | 17-213  | PTKc_Csk_like |
| cd13968 | 19-165  | PKc_like |
| cd05575 | 19-307  | STKc_SGK |
| cd14665 | 12-299  | STKc_SnRK2-3 |
| cd05586 | 19-304  | STKc_Sck1_like |
| cd05068 | 19-212  | PTKc_Frk_like |
| cd14147 | 19-221  | STKc_MLK3 |
| cd05052 | 19-212  | PTKc_Abl |
| cd14175 | 72-318  | STKc_RSK1_C |
| cd05044 | 19-211  | PTKc_c-ros |
| cd05610 | 11-316  | STKc_MASTL |
| cd14172 | 67-299  | STKc_MAPKAPK3 |
| cd14088 | 24-299  | STKc_CaMK_like |
| cd06618 | 12-304  | PKc_MKK7 |
| cd05055 | 19-213  | PTKc_PDGFR |
| cd05606 | 19-316  | STKc_beta_ARK |
| cd05081 | 16-213  | PTKc_Jak3_rpt2 |
| cd14178 | 61-309  | STKc_RSK3_C |
| cd05033 | 16-244  | PTKc_EphR |
| cd05591 | 124-304  | STKc_nPKC_epsilon |
| cd14041 | 10-300  | STKc_TLK2 |
| cd14191 | 13-300  | STKc_MLCK1 |
| cd05624 | 13-304  | STKc_MRCK_beta |
| cd05595 | 19-325  | STKc_PKB_beta |
| cd05113 | 18-213  | PTKc_Btk_Bmx |
| cd05092 | 18-213  | PTKc_TrkA |
| cd05067 | 16-212  | PTKc_Lck_Blk |
| cd05632 | 104-303  | STKc_GRK5 |
| cd14176 | 13-299  | STKc_RSK2_C |
| cd05045 | 19-212  | PTKc_RET |
| cd05592 | 19-228  | STKc_nPKC_theta_like |
| cd14078 | 13-299  | STKc_MELK |
| cd05057 | 14-217  | PTKc_EGFR_like |
| cd14056 | 18-215  | STKc_TGFbR_I |
| cd14209 | 11-212  | STKc_PKA |
| cd14040 | 10-300  | STKc_TLK1 |
| cd14101 | 12-301  | STKc_PIM2 |
| cd14156 | 19-217  | PKc_LIMK_like_unk |
| cd05602 | 19-233  | STKc_SGK1 |
| cd05080 | 18-215  | PTKc_Tyk2_rpt2 |
| cd05587 | 132-289  | STKc_cPKC |
| cd14039 | 19-211  | STKc_IKK_alpha |
| cd05061 | 18-303  | PTKc_InsR |
| cd14177 | 72-323  | STKc_RSK4_C |
| cd14110 | 11-206  | STKc_obscurin_rpt2 |
| cd05589 | 13-212  | STKc_PKN |
| cd05608 | 19-316  | STKc_GRK1 |
| cd05620 | 19-301  | STKc_nPKC_delta |
| cd05116 | 18-228  | PTKc_Syk |
| cd14037 | 19-207  | STKc_NAK_like |
| cd14165 | 19-300  | STKc_TSSK1_2-like |
| cd05097 | 11-213  | PTKc_DDR_like |
| cd14187 | 126-222  | STKc_PLK1 |
| cd14223 | 19-227  | STKc_GRK2 |
| cd14062 | 19-228  | STKc_Raf |
| cd05633 | 19-227  | STKc_GRK3 |
| cd14016 | 12-170  | STKc_CK1 |
| cd05075 | 19-215  | PTKc_Axl |
| cd05618 | 11-224  | STKc_aPKC_iota |
| cd14664 | 19-226  | STK_BAK1_like |
| cd05074 | 10-215  | PTKc_Tyro3 |
| cd05597 | 13-232  | STKc_DMPK_like |
| cd14189 | 128-300  | STKc_PLK3 |
| cd05072 | 16-247  | PTKc_Lyn |
| cd05095 | 18-253  | PTKc_DDR2 |
| cd14027 | 22-260  | STKc_RIP1 |
| cd14662 | 12-206  | STKc_SnRK2 |
| cd14170 | 19-299  | STKc_MAPKAPK2 |
| cd14064 | 19-213  | PKc_TNNI3K |
| cd14221 | 19-233  | STKc_LIMK1 |
| cd14207 | 121-213  | PTKc_VEGFR1 |
| cd05623 | 11-277  | STKc_MRCK_alpha |
| cd14173 | 19-299  | STKc_Mnk2 |
| cd13988 | 19-209  | STKc_TBK1 |
| cd05102 | 19-213  | PTKc_VEGFR3 |
| cd14104 | 12-301  | STKc_Titin |
| cd14031 | 18-212  | STKc_WNK3 |
| cd05047 | 19-212  | PTKc_Tie |
| cd05108 | 19-217  | PTKc_EGFR |
| cd05596 | 117-316  | STKc_ROCK |
| cd14155 | 19-215  | PKc_TESK |
| cd14188 | 19-219  | STKc_PLK2 |
| cd05593 | 19-325  | STKc_PKB_gamma |
| cd06616 | 18-206  | PKc_MKK4 |
| cd05093 | 18-224  | PTKc_TrkB |
| cd05103 | 19-213  | PTKc_VEGFR2 |
| cd05051 | 11-217  | PTKc_DDR |
| cd14060 | 20-221  | STKc_MLTK |
| cd14032 | 18-212  | STKc_WNK2_like |
| cd05616 | 132-228  | STKc_cPKC_beta |
| cd14171 | 61-299  | STKc_MAPKAPK5 |
| cd05615 | 19-228  | STKc_cPKC_alpha |
| cd14054 | 19-223  | STKc_BMPR2_AMHR2 |
| cd05617 | 7-219  | STKc_aPKC_zeta |
| cd05070 | 3-264  | PTKc_Fyn |
| cd14158 | 19-235  | STKc_IRAK4 |
| cd05115 | 18-217  | PTKc_Zap-70 |
| cd08216 | 14-316  | PK_STRAD |
| cd05036 | 19-213  | PTKc_ALK_LTK |
| cd05065 | 19-244  | PTKc_EphR_B |
| cd14112 | 12-208  | STKc_Unc-89_rpt2 |
| cd14163 | 13-213  | STKc_TSSK3-like |
| cd05042 | 18-251  | PTKc_Aatyk |
| cd05107 | 87-213  | PTKc_PDGFR_beta |
| cd14070 | 19-206  | STKc_HUNK |
| cd14206 | 18-213  | PTKc_Aatyk3 |
| cd05073 | 18-217  | PTKc_Hck |
| cd13991 | 19-212  | STKc_NIK |
| cd05109 | 19-217  | PTKc_HER2 |
| cd14017 | 12-170  | STKc_TTBK |
| cd14030 | 18-302  | STKc_WNK1 |
| cd13992 | 20-288  | PK_GC |
| cd05071 | 18-212  | PTKc_Src |
| cd05627 | 13-308  | STKc_NDR2 |
| cd14068 | 19-288  | STKc_LRRK2 |
| cd05088 | 19-212  | PTKc_Tie2 |
| cd14204 | 19-215  | PTKc_Mer |
| cd05621 | 11-253  | STKc_ROCK2 |
| cd05058 | 19-215  | PTKc_Met_Ron |
| cd05094 | 18-220  | PTKc_TrkC |
| cd05105 | 116-213  | PTKc_PDGFR_alpha |
| cd05035 | 19-215  | PTKc_TAM |
| cd05063 | 19-274  | PTKc_EphR_A2 |
| cd14203 | 18-212  | PTKc_Src_Fyn_like |
| cd14018 | 33-291  | STKc_PINK1 |
| cd05111 | 19-212  | PTK_HER3 |
| cd14222 | 19-212  | STKc_LIMK2 |
| cd05114 | 18-226  | PTKc_Tec_Rlk |
| cd05069 | 18-215  | PTKc_Yes |
| cd05096 | 59-305  | PTKc_DDR1 |
| cd13980 | 126-291  | STKc_Vps15 |
| cd05110 | 16-217  | PTKc_HER4 |
| cd05082 | 19-220  | PTKc_Csk |
| cd05089 | 19-212  | PTKc_Tie1 |
| cd05622 | 11-246  | STKc_ROCK1 |
| cd05588 | 19-212  | STKc_aPKC |
| cd05594 | 13-219  | STKc_PKB_alpha |
| cd05066 | 19-212  | PTKc_EphR_A |
| cd14151 | 10-228  | STKc_B-Raf |
| cd08226 | 56-316  | PK_STRAD_beta |
| cd14053 | 22-191  | STKc_ACVR2 |
| cd05104 | 99-213  | PTKc_Kit |
| cd05628 | 11-233  | STKc_NDR1 |
| cd05106 | 19-213  | PTKc_CSF-1R |
| cd14144 | 19-291  | STKc_BMPR1 |
| TIGR03724 | 79-169  | arch_bud32 |
| COG3642 | 136-169  | Bud32 |
| COG0510 | 120-164  | CotS |
| smart00220 | 13-300  | S_TKc |
| PLN00009 | 11-304  | PLN00009 |
| pfam00069 | 13-300  | Pkinase |
| PTZ00024 | 10-301  | PTZ00024 |
| COG0515 | 13-317  | SPS1 |
| PTZ00036 | 19-303  | PTZ00036 |
| smart00221 | 18-213  | STYKc |
| smart00219 | 18-213  | TyrKc |
| pfam07714 | 18-206  | Pkinase_Tyr |
| PHA03209 | 9-303  | PHA03209 |
| PLN00034 | 14-299  | PLN00034 |
| PTZ00266 | 4-228  | PTZ00266 |
| PHA03212 | 22-303  | PHA03212 |
| PHA03211 | 43-301  | PHA03211 |
| PTZ00263 | 19-300  | PTZ00263 |
| PTZ00267 | 125-232  | PTZ00267 |
| TIGR03903 | 37-250  | TOMM_kin_cyc |
| PTZ00284 | 11-299  | PTZ00284 |
| PHA03210 | 11-300  | PHA03210 |
| PHA03207 | 12-219  | PHA03207 |
| PHA03390 | 72-300  | pk1 |
| PRK13184 | 11-276  | pknD |
| PLN03225 | 122-301  | PLN03225 |
| PTZ00283 | 125-232  | PTZ00283 |
| PTZ00426 | 11-235  | PTZ00426 |
Ontology Information
| HPRD ID | 3426 |    
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Ligase activity (GO:0016874) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q00534 | DB09073 | Palbociclib | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

