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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GDF11 | 10220 | growth differentiation factor 11 | 12 | BMP-11 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17912435 | 2007 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 130 Stage : - | real time RT-PCR | Up-regulation | - | GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. |
| Chromosome | 12 |
| Location | 12q13.13 |
| Start | 55743278 |
| End | 55757466 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14189 |
| OMIM ID | 603936 |
| HGNC ID | HGNC:4216 |
| Unigene ID | Hs.600883 |
| Ensembl ID | ENSG00000135414 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_006719194.2 |
|---|---|
| Exon | join(1..484,5309..5706,6225..6606,13736..14189) | mRNA Sequence | Download Select all |
| Length | 4260 |
CDS Information
| Location | join(40..484,5309..5706,6225..6605) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8891.1 |
Protein Information
| Protein ID | NP_005802.1 |
|---|---|
| Protein Name | growth differentiation factor 11 |
| Molecular Wt. (Da) | 42532 |
| Protein Sequence | Download Select all |
| Length | 407 |
| Uniprot ID | P35568 |
| Ensembl Protein ID | ENSP00000304895 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 93 | ACVR2B | 4106 | NP_001097.2 | in vitro;in vivo | 16845371 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00688 | 60-287 | TGFb_propeptide |
| cl02928 | 60-287 | TGFb_propeptide superfamily |
| smart00204 | 313-407 | TGFB |
| cl02510 | 313-407 | TGF_beta superfamily |
| pfam00019 | 313-407 | TGF_beta |
| PHA02913 | 310-406 | PHA02913 |
Ontology Information
| HPRD ID | 1893 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.