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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26090413 | 2005 | Cell line : - Source : - Sample Type : Mouse model No. of Sample : - Stage : - | SDS-PAGE and Western Blotting,Immunoreactivity Assays, Immunoreactivity Assay | Up-regulation | - | CF750-A33scFv-Fc can target GPA33, suggesting the potential of CF750-A33scFv-Fc as an imaging agent for the diagnosis of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / V-set domain containing, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q24.1 |
| Start | 167022082 |
| End | 167059868 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 37787 |
| OMIM ID | 602171 |
| HGNC ID | HGNC:4445 |
| Unigene ID | Hs.651244 |
| Ensembl ID | ENSG00000143167 |
| PharmGKB ID | PA28826 |
Protein Information
| Protein ID | NP_005805.1 |
|---|---|
| Protein Name | glycoprotein A33 (transmembrane) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 319 |
| Uniprot ID | Q9NUX5 |
| Ensembl Protein ID | ENSP00000350249 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00406 | 38-119 | IGv |
| cl11960 | 38-119 | Ig superfamily |
| cd05714 | 35-129 | Ig_CSPGs_LP |
| cd00099 | 33-124 | IgV |
| cd05877 | 35-120 | Ig_LP_like |
| cd05715 | 24-137 | Ig_P0-like |
| cd05878 | 36-119 | Ig_Aggrecan_like |
| cd04983 | 24-120 | IgV_TCR_alpha_like |
| cd05718 | 37-138 | Ig1_PVR_like |
| cd05880 | 24-137 | Ig_EVA1 |
| pfam07686 | 21-134 | V-set |
| cd05716 | 30-119 | Ig_pIgR |
| cd05901 | 38-119 | Ig_Versican |
| pfam13927 | 149-215 | Ig_3 |
| cl11960 | 149-215 | Ig superfamily |
| cd05775 | 35-133 | Ig_SLAM-CD84_like_N |
| cd05888 | 39-138 | Ig1_Nectin-4_like |
| cd05879 | 24-137 | Ig_P0 |
| cd05728 | 154-228 | Ig4_Contactin-2-like |
| pfam13895 | 154-226 | Ig_2 |
| cd05733 | 158-219 | Ig6_L1-CAM_like |
| cd05869 | 158-218 | Ig5_NCAM-1 |
| cd05731 | 158-229 | Ig3_L1-CAM_like |
| cd04978 | 155-229 | Ig4_L1-NrCAM_like |
| cd05856 | 154-218 | Ig2_FGFRL1-like |
| cd07706 | 28-129 | IgV_TCR_delta |
| cd05737 | 152-228 | Ig_Myomesin_like_C |
| cd05846 | 36-118 | Ig1_MRC-OX-2_like |
| cd05736 | 160-218 | Ig2_Follistatin_like |
| cd05887 | 37-138 | Ig1_Nectin-3_like |
| cd05851 | 153-218 | Ig3_Contactin-1 |
| cd05900 | 36-119 | Ig_Aggrecan |
| cd05874 | 158-223 | Ig6_NrCAM |
| cd05732 | 148-218 | Ig5_NCAM-1_like |
| cd00096 | 158-225 | Ig |
| cd05891 | 155-228 | Ig_M-protein_C |
| cd05724 | 151-219 | Ig2_Robo |
| cd05892 | 158-228 | Ig_Myotilin_C |
| cd05741 | 36-137 | Ig_CEACAM_D1_like |
| smart00408 | 154-218 | IGc2 |
| smart00410 | 27-137 | IG_like |
| smart00410 | 155-228 | IG_like |
| smart00409 | 155-228 | IG |
| smart00409 | 27-137 | IG |
| pfam07679 | 148-228 | I-set |
Ontology Information
| HPRD ID | 5943 |
|---|---|
| Molecular Class | Immunoglobulin |
| Molecular Function | Intracellular ligand-gated ion channel activity (GO:0005217) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.