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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDKN1A | 1026 | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 6 | P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16850502 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 737 Stage : TNM stage I-IV | real-time RT-PCR, Immunohistochemistry | Down-regulation | - | Down-regulation of p21 is inversely correlated with CIMP-high and MSI-H in colorectal cancer, independent of TP53 and BRAF status. |
| 17086168 | 2007 | Cell line : - Source : - Sample Type : Population-based case-control studies No. of Sample : Health Study 121700 women and the Health Professional Follow-up Study 51500 Stage : - | MethyLight assays, Immunohistochemistry | Down-regulation | - | CIMP and MSI-H are inversely associated with downregulation of p21 (CDKN1A or CIP1). |
| 21637966 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 65 Stage : TNM stage I-IV | Immunohistochemistry | Down-regulation | - | A series of 65 CRC patients were analyzed for p27 and p21 expression in their tumors using immunohistochemistry. Forty-six percent of tumors showed positive nuclear p27 expression, whereas 72% of cases were completely p21 negative. |
| 22634755 | 2012 | Cell line : - Source : - Sample Type : Population-based case-control studies No. of Sample : 8,682 CRC cases and 9,649 controls Stage : - | Meta-analysis, Replication analysis. | Polymorhpism | - | 5 genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk. Identified three new CRC risk loci at 6p21 rs1321311, near CDKN1A. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] |
| Chromosome | 6 |
| Location | 6p21.2 |
| Start | 36676460 |
| End | 36687339 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10880 |
| OMIM ID | 116899 |
| HGNC ID | HGNC:1784 |
| Unigene ID | Hs.370771 |
| Ensembl ID | ENSG00000124762 |
| PharmGKB ID | PA104 |
mRNA Information
| mRNA ID | NM_001220777.1 |
|---|---|
| Exon | join(1..65,7638..8087,9292..10880) | mRNA Sequence | Download Select all |
| Length | 2119 |
CDS Information
| Location | join(1378..1474,7638..8087,9292..9341) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_000380.1 |
|---|---|
| Protein Name | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| Molecular Wt. (Da) | 17988 |
| Protein Sequence | Download Select all |
| Length | 164 |
| Uniprot ID | P98170 |
| Ensembl Protein ID | ENSP00000347858 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 145 |
| S | Phosphorylation | 146 |
| T | Phosphorylation | 145 |
| S | Phosphorylation | 146 |
| T | Phosphorylation | 145 |
| T | Phosphorylation | 145 |
| D | Proteolytic Cleavage | 112 |
| D | Proteolytic Cleavage | 149 |
| D | Proteolytic Cleavage | 112 |
| D | Proteolytic Cleavage | 149 |
| S | Phosphorylation | 130 |
| T | Phosphorylation | 57 |
| S | Phosphorylation | 130 |
| T | Phosphorylation | 57 |
| T | Phosphorylation | 145 |
| T | Phosphorylation | 145 |
| D | Proteolytic Cleavage | 112 |
| D | Proteolytic Cleavage | 112 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 894 | CCND2 | 451 | NP_001750.1 | in vivo;yeast 2-hybrid | 1 618 951 416 765 340 |
| 1050 | CEBPA | 296 | NP_004355.2 | in vitro | 9372966 |
| 1457 | CSNK2A1 | 277 | NP_001886.1 | in vitro | 11255227 |
| 1460 | CSNK2B | 278 | NP_001311.3 | in vitro | 10679299 |
| 4217 | MAP3K5 | 3904 | NP_005914.1 | in vivo | 12820963 |
| 5861 | RAB1A | 1538 | NP_004152.1 | yeast 2-hybrid | 16169070 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 10764767 |
| 8402 | SLC25A11 | 5003 | NP_003553.2 | yeast 2-hybrid | 16169070 |
| 10399 | GNB2L1 | 1503 | NP_006089.1 | yeast 2-hybrid | 16169070 |
| 11007 | CCDC85B | 16101 | NP_006839.2 | yeast 2-hybrid | 16189514 |
| 23093 | TTLL5 | 8309 | NP_055887.3 | yeast 2-hybrid | 16169070 |
| 27231 | ITGB1BP3 | 16371 | NP_733778.1 | yeast 2-hybrid | 16169070 |
| 51053 | GMNN | 6783 | NP_056979.1 | in vitro | 15232106 |
| 51608 | C7orf20 | 12909 | NP_057033.2 | yeast 2-hybrid | 16169070 |
| 54987 | C1orf123 | 7929 | NP_060357.1 | yeast 2-hybrid | 16169070 |
| 56159 | TEX11 | 2256 | NP_001003811.1 | yeast 2-hybrid | 16189514 |
| 79885 | HDAC11 | 9146 | NP_079103.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bladder cancer | hsa05219 |
| Cell cycle | hsa04110 |
| Chronic myeloid leukemia | hsa05220 |
| Epstein-Barr virus infection | hsa05169 |
| ErbB signaling pathway | hsa04012 |
| FoxO signaling pathway | hsa04068 |
| Glioma | hsa05214 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| HIF-1 signaling pathway | hsa04066 |
| HTLV-I infection | hsa05166 |
| Jak-STAT signaling pathway | hsa04630 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| Oxytocin signaling pathway | hsa04921 |
| p53 signaling pathway | hsa04115 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Proteoglycans in cancer | hsa05205 |
| Transcriptional misregulation in cancer | hsa05202 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 1AXC |
|---|---|
| Resolution | 2.6 |
| Method | X-RAY DIFFRACTION |
| Chains | A,C,E |
| Molecule | PCNA |
| Model | View |
Ontology Information
| HPRD ID | 2094 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Ligase activity (GO:0016874) |
| Biological Process | Anti-apoptosis (GO:0006916) |
Drug Information
No matching records could be found.