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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDKN2B | 1030 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 9 | P15, MTS2, INK4B, TP15, CDK4I, p15INK4b |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25202407 | 2014 | Cell line : HT29, GC3/c1 Source : - Sample Type : - No. of Sample : - Stage : - | Transfection,real time RT-PCR,Western blotting, luciferase reporter assay,Transwell invasion assay, MTT assay,Apoptosis assay | Down-regulation | - | - |
| 20957031 | 2010 | Cell line : - Source : The Second Xiangya Hospital of Central South University (Changsha, China). Sample Type : CRC tumor and normal tissue No. of Sample : 5 Stage : - | Microarray ,GenomeStudio (statistics), Matlab (heat map), Ingenuity (canonical pathway analysis),real time RT-PCR | Up-regulation | - | p21(Cip1) (CDKN1A) and p15(Ink4b) (CDKN2B), which play a role in the G1/S checkpoint, as up-regulated genes at the G1/S boundary. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
| Chromosome | 9 |
| Location | 9p21 |
| Start | 22002902 |
| End | 22009312 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6411 |
| OMIM ID | 600431 |
| HGNC ID | HGNC:1788 |
| Unigene ID | Hs.72901 |
| Ensembl ID | ENSG00000147883 |
| PharmGKB ID | PA26321 |
mRNA Information
| mRNA ID | NM_004936.3 |
|---|---|
| Exon | join(1..516,3067..6411) | mRNA Sequence | Download Select all |
| Length | 3878 |
Protein Information
| Protein ID | NP_004927.2 |
|---|---|
| Protein Name | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
| Molecular Wt. (Da) | 14591 |
| Protein Sequence | Download Select all |
| Length | 138 |
| Uniprot ID | P06748 |
| Ensembl Protein ID | ENSP00000296930 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1019 | CDK4 | 447 | NP_000066.1 | in vitro;in vivo | 911 131 491 634 297 000 000 |
| 8518 | IKBKAP | 4763 | NP_003631.2 | yeast 2-hybrid | 16169070 |
| 10094 | ARPC3 | 9175 | NP_005710.1 | yeast 2-hybrid | 16169070 |
| 57562 | KIAA1377 | 17212 | NP_065853.2 | yeast 2-hybrid | 16169070 |
| 60492 | CCDC90B | 14378 | NP_068597.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| FoxO signaling pathway | hsa04068 |
| HTLV-I infection | hsa05166 |
| Pathways in cancer | hsa05200 |
| Small cell lung cancer | hsa05222 |
| TGF-beta signaling pathway | hsa04350 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00204 | 21-132 | ANK |
| cl02529 | 21-132 | ANK superfamily |
| cd00204 | 21-66 | ANK |
| cd00204 | 83-132 | ANK |
| pfam12796 | 18-110 | Ank_2 |
| COG0666 | 18-135 | ANKYR |
| pfam12796 | 55-132 | Ank_2 |
| PTZ00322 | 52-132 | PTZ00322 |
| PHA02878 | 28-120 | PHA02878 |
| PHA03095 | 28-134 | PHA03095 |
| pfam13857 | 65-120 | Ank_5 |
| PTZ00322 | 18-101 | PTZ00322 |
| PHA02876 | 20-123 | PHA02876 |
| PHA02874 | 28-136 | PHA02874 |
| pfam13637 | 81-132 | Ank_4 |
| PLN03192 | Sep-76 | PLN03192 |
| PHA03095 | 27-118 | PHA03095 |
| PHA03095 | 27-132 | PHA03095 |
| PLN03192 | 51-113 | PLN03192 |
| pfam13637 | 18-66 | Ank_4 |
| PHA03095 | 27-120 | PHA03095 |
| PHA02946 | 19-76 | PHA02946 |
| TIGR00870 | 13-72 | trp |
Ontology Information
| HPRD ID | 1273 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.