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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDKN3 | 1033 | cyclin-dependent kinase inhibitor 3 | 14 | KAP, CDI1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25735390 | 2015 | Cell line : RKO, SW480, SW620, HCT 116, HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Cellular proliferation assay,real time RT-PCR, flow cytometry,Transwell invasion assay,SDS-PAGE and western blotting | Up-regulation | - | The in vitro studies in SW480 cells revealed a unique role of CDKN3 in regulating cellular behavior of colorectal cancer cells, and implied the possibility of targeting CDKN3 as a novel treatment for colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : CDC14s |
| Description | The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| Chromosome | 14 |
| Location | 14q22 |
| Start | 54863657 |
| End | 54886936 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 23280 |
| OMIM ID | 123832 |
| HGNC ID | HGNC:1791 |
| Unigene ID | Hs.84113 |
| Ensembl ID | ENSG00000100526 |
| PharmGKB ID | PA26324 |
mRNA Information
| mRNA ID | XM_011536353.1 |
|---|---|
| Exon | join(1..144,2961..3043,4591..4646,11812..11856, 14551..14773,18966..18997,20915..21018,21281..21373) | mRNA Sequence | Download Select all |
| Length | 780 |
Protein Information
| Protein ID | XP_011534655.1 |
|---|---|
| Protein Name | cyclin-dependent kinase inhibitor 3 |
| Molecular Wt. (Da) | 22382 |
| Protein Sequence | Download Select all |
| Length | 203 |
| Uniprot ID | Q15818 |
| Ensembl Protein ID | ENSP00000307549 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 983 | CDK1 | 302 | NP_001777.1 | in vitro;in vivo;yeast 2-hybrid | 8127873 |
| 993 | CDC25A | 305 | NP_001780.2 | in vitro | 9989807 |
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro;in vivo;yeast 2-hybrid | 1 274 507 511 463 380 000 000 000 000 000 000 000 |
| 1018 | CDK3 | 446 | NP_001249.1 | in vivo;yeast 2-hybrid | 8242750 |
| 1050 | CEBPA | 296 | NP_004355.2 | in vivo | 11684017 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05706 | 1-168 | CDKN3 |
| cl21483 | 1-168 | PTPc superfamily |
| smart00404 | 104-191 | PTPc_motif |
| smart00012 | 104-191 | PTPc_DSPc |
| cd00047 | 101-191 | PTPc |
| PTZ00242 | 83-193 | PTZ00242 |
| PTZ00393 | 65-195 | PTZ00393 |
| cd00127 | 96-177 | DSPc |
| smart00195 | 113-177 | DSPc |
| pfam00782 | 128-176 | DSPc |
| COG2453 | 100-192 | CDC14 |
| pfam00102 | 74-191 | Y_phosphatase |
| smart00194 | 74-191 | PTPc |
| PRK12361 | 107-195 | PRK12361 |
Ontology Information
| HPRD ID | 7207 |
|---|---|
| Molecular Class | Dual specificity phosphatase |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.