Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BTN3A3 | 10384 | Butyrophilin, subfamily 3, member A3 | 6 | BTF3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531130 | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 Stage : TNM Stage I-IV | Peptide Nucleic Acid (PNA)-clamp real-timeRT-PCR TaqMan assay, Gene expression profiles. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / V-set domain containing, Proteoglycans / Extracellular Matrix : Hyalectans |
| Description | The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010] |
| Chromosome | 6 |
| Location | 6p21.3 |
| Start | 26440472 |
| End | 26453415 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12944 |
| OMIM ID | 613595 |
| HGNC ID | HGNC:1140 |
| Unigene ID | Hs.167741 |
| Ensembl ID | ENSG00000111801 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011514268.1 |
|---|---|
| Exon | <11160..11182 | mRNA Sequence | Download Select all |
| Length | 1325 |
CDS Information
| Location | join(3104..3188,3486..3833,5233..5514,7777..7977, 8146..8166,8257..8283,9191..9217,9636..9662,11204..11940) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4611.1 |
Protein Information
| Protein ID | NP_008925.1 |
|---|---|
| Protein Name | Butyrophilin, subfamily 3, member A3 |
| Molecular Wt. (Da) | 61824 |
| Protein Sequence | Download Select all |
| Length | 584 |
| Uniprot ID | P04626 |
| Ensembl Protein ID | ENSP00000269571 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 115 |
| N | Glycosylation | 73 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd12900 | 340-512 | SPRY_PRY_Btn_TRIMs |
| cl02614 | 340-512 | SPRY superfamily |
| cd05713 | 45-144 | Ig_MOG_like |
| cl11960 | 45-144 | Ig superfamily |
| cd12905 | 341-499 | SPRY_PRY_TRIM_Bty_69_NF7 |
| cd12888 | 341-512 | SPRY_PRY_TRIM7_like |
| cd12897 | 339-499 | SPRY_PRY_TRIM50_62_72 |
| cd12893 | 342-513 | SPRY_PRY_TRIM35 |
| cd13733 | 341-512 | SPRY_PRY_C-IV_1 |
| cd13745 | 340-499 | SPRY_PRY_TRIM39 |
| cd12874 | 342-512 | SPRY_PRY |
| cd13741 | 341-513 | SPRY_PRY_TRIM41 |
| cd13740 | 341-513 | SPRY_PRY_TRIM7 |
| cd12891 | 342-512 | SPRY_PRY_C-IV_2 |
| smart00449 | 392-514 | SPRY |
| cd13743 | 339-498 | SPRY_PRY_TRIM50 |
| cd13744 | 339-499 | SPRY_PRY_TRIM62 |
| cd13734 | 344-512 | SPRY_PRY_C-I |
| cd13742 | 339-499 | SPRY_PRY_TRIM72 |
| pfam00622 | 392-499 | SPRY |
| cd12892 | 344-519 | SPRY_PRY_TRIM18 |
| cd13738 | 344-501 | SPRY_PRY_TRIM14 |
| cd12896 | 345-512 | SPRY_PRY_TRIM65 |
| cd12890 | 344-499 | SPRY_PRY_TRIM16 |
| cd12899 | 344-511 | SPRY_PRY_TRIM76_like |
| smart00589 | 339-390 | PRY |
| cl02686 | 339-390 | PRY superfamily |
| pfam13765 | 342-390 | PRY |
| cd12904 | 344-499 | SPRY_BSPRY |
| cd12902 | 345-511 | SPRY_PRY_RNF135 |
| cd13736 | 342-512 | SPRY_PRY_TRIM25 |
| cd12898 | 347-499 | SPRY_PRY_TRIM76 |
| cd13739 | 344-501 | SPRY_PRY_TRIM1 |
| cd12903 | 344-499 | SPRY_PRY_SPRYD4 |
| cd12901 | 382-501 | SPRY_PRY_FSD1 |
| cd11709 | 393-499 | SPRY |
| cd13737 | 344-497 | SPRY_PRY_TRIM25-like |
| smart00406 | 47-126 | IGv |
| cd05714 | 45-143 | Ig_CSPGs_LP |
| cd05877 | 45-143 | Ig_LP_like |
| cd12889 | 344-475 | SPRY_PRY_TRIM67_9 |
| cd12894 | 454-502 | SPRY_PRY_TRIM36 |
| cd05878 | 45-143 | Ig_Aggrecan_like |
| cd00096 | 50-140 | Ig |
| cd05718 | 46-129 | Ig1_PVR_like |
| cd12885 | 396-501 | SPRY_RanBP_like |
| cd00099 | 40-126 | IgV |
| smart00410 | 37-143 | IG_like |
| smart00409 | 37-143 | IG |
| pfam07679 | 32-126 | I-set |
| COG4191 | 227-313 | COG4191 |
Ontology Information
| HPRD ID | 530 |
|---|---|
| Molecular Class | Immunoglobulin |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.