Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MRLC2 | 103910 | Myosin regulatory light chain MRLC2  | 18 | MLC-B; MRLC2  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tissue and blood sample No. of Sample : - Stage : TNM Stage II | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Myosins / Light chain, EF-hand domain containing |
| Description | The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]   |
| Chromosome | 18 |
| Location | 18p11.31 |
| Start | 3262113   |
| End | 3278284   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 16172   |
| OMIM ID | 609211    |
| HGNC ID | HGNC:29827    |
| Unigene ID | Hs.464472     |
| Ensembl ID | ENSG00000118680    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_033546.3 |
|---|---|
| Exon | join(1..125,10772..10970,15141..15302,15653..16172)   | mRNA Sequence |    Download   Select all |
| Length | 1022   |
CDS Information
| Location | join(10787..10970,15141..15302,15653..15825) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS11831.1 |    
Protein Information
| Protein ID | NP_001138416.1 |
|---|---|
| Protein Name | Myosin regulatory light chain MRLC2 |
| Molecular Wt. (Da) | 19648 |
| Protein Sequence |    Download   Select all |
| Length | 172   |
| Uniprot ID | P53539 |    
| Ensembl Protein ID | ENSP00000245919   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 19 |
| S | Phosphorylation | 20 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Focal adhesion |    hsa04510 |    
| Leukocyte transendothelial migration |    hsa04670 |    
| Platelet activation |    hsa04611 |    
| Regulation of actin cytoskeleton |    hsa04810 |    
| Tight junction |    hsa04530 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00051 | 33-77  | EFh |
| cl08302 | 33-77  | EFh superfamily |
| pfam13405 | 33-62  | EF-hand_6 |
| cl23634 | 33-62  | EF-hand_6 superfamily |
| smart00054 | 33-61  | EFh |
| cl23347 | 33-61  | EFh superfamily |
| cd00051 | 103-164  | EFh |
| cl08302 | 103-164  | EFh superfamily |
| pfam00036 | 33-61  | EF-hand_1 |
| cl23489 | 33-61  | EF-hand_1 superfamily |
| pfam13833 | 114-165  | EF-hand_8 |
| COG5126 | 19-169  | FRQ1 |
| PTZ00184 | 25-163  | PTZ00184 |
| PTZ00183 | 26-164  | PTZ00183 |
Ontology Information
| HPRD ID | 196 |    
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Fucosyltransferase activity (GO:0008417) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
