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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MRLC2 103910 Myosin regulatory light chain MRLC2  18MLC-B; MRLC2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tissue and blood sample

No. of Sample : -

Stage : TNM Stage II

Biochemical isolation to nano-LC-MS/MS analysisUp-regulation--


Gene Details



Chromosome: 18; NC_000018.9 (3262111..3278282)

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Gene Type protein coding
Gene Family Myosins / Light chain, EF-hand domain containing
Description The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]  
Chromosome 18
Location 18p11.31
Start 3262113  
End 3278284  
Strand +  
Gene Sequence

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Length 16172  
OMIM ID 609211   
HGNC ID HGNC:29827   
Unigene ID Hs.464472    
Ensembl ID ENSG00000118680   
PharmGKB ID -   

mRNA Information


mRNA ID NM_033546.3
Exon join(1..125,10772..10970,15141..15302,15653..16172)  
mRNA Sequence

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Length 1022  



CDS Information


   
Locationjoin(10787..10970,15141..15302,15653..15825)
CDS Sequence

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CCDS ID CCDS11831.1



Protein Information


      
Protein IDNP_001138416.1
Protein NameMyosin regulatory light chain MRLC2
Molecular Wt. (Da)19648
Protein Sequence

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Length 172  
Uniprot IDP53539
Ensembl Protein ID ENSP00000245919  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation19
SPhosphorylation20

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                              
Pathway Name Pathway ID
Focal adhesion hsa04510
Leukocyte transendothelial migration hsa04670
Platelet activation hsa04611
Regulation of actin cytoskeleton hsa04810
Tight junction hsa04530


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0005133-77  EFh
cl0830233-77  EFh superfamily
pfam1340533-62  EF-hand_6
cl2363433-62  EF-hand_6 superfamily
smart0005433-61  EFh
cl2334733-61  EFh superfamily
cd00051103-164  EFh
cl08302103-164  EFh superfamily
pfam0003633-61  EF-hand_1
cl2348933-61  EF-hand_1 superfamily
pfam13833114-165  EF-hand_8
COG512619-169  FRQ1
PTZ0018425-163  PTZ00184
PTZ0018326-164  PTZ00183


Ontology Information


   
HPRD ID196
Molecular ClassUnknown
Molecular FunctionFucosyltransferase activity (GO:0008417)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO