Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PIAS3 | 10401 | protein inhibitor of activated STAT, 3 | 1 | FLJ14651, ZMIZ5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24120699 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | - | Up-regulation | - | PIAS3 may be a potential biomarker target for early cancer detection and therapeutic of human CRC. Protein Inhibitor of Activated Signal Transducer and Activators of Transcription 3 (PIAS3) as a novel biomarker has been focused to have a role in the development of malignancy, which was expressed at a higher level in most common malignancies compared with corresponding normal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, MIZ-type |
| Description | This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. |
| Chromosome | 1 |
| Location | 1q21 |
| Start | 145848522 |
| End | 145859081 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10560 |
| OMIM ID | 605987 |
| HGNC ID | HGNC:16861 |
| Unigene ID | Hs.435761 |
| Ensembl ID | ENSG00000131788 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011509259.1 |
|---|---|
| Exon | complement(<10329..>10560) | mRNA Sequence | Download Select all |
| Length | 2902 |
CDS Information
| Location | join(92..115,2076..2493,2651..2735,2964..3014,3256..3346, 4202..4336,4519..4624,5196..5269,5418..5578,7929..8062, 8143..8311,8496..8629,8813..8850,9370..9636) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS72866.1 |
Protein Information
| Protein ID | NP_006090.2 |
|---|---|
| Protein Name | protein inhibitor of activated STAT, 3 |
| Molecular Wt. (Da) | 67887 |
| Protein Sequence | Download Select all |
| Length | 628 |
| Uniprot ID | P13612 |
| Ensembl Protein ID | ENSP00000340149 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2672 | GFI1 | 7527 | NP_005254.2 | in vitro;in vivo;yeast 2-hybrid | 11060035 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vivo | 14691252 |
| 4087 | SMAD2 | 3221 | NP_005892.1 | in vitro | 14691252 |
| 4089 | SMAD4 | 2995 | NP_005350.1 | in vitro;in vivo | 14691252 |
| 4286 | MITF | 1138 | NP_937802.1 | in vitro;in vivo;yeast 2-hybrid | 11709556 |
| 5956 | OPN1LW | 2366 | NP_064445.1 | in vitro;in vivo | 14691252 |
| 5970 | RELA | 1241 | NP_068810.3 | in vivo;yeast 2-hybrid | 15140884 |
| 6498 | SKIL | 1319 | NP_005405.2 | yeast 2-hybrid | 15231748 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 1 142 941 212 804 600 |
| 8091 | HMGA2 | 2827 | NP_003474.1 | in vivo;yeast 2-hybrid | 11390395 |
| 10499 | NCOA2 | 9066 | NP_006531.1 | in vitro;in vivo;yeast 2-hybrid | 12208521 |
| 55660 | PRPF40A | 10995 | NP_060362.3 | yeast 2-hybrid | 15231748 |
| 55729 | ATF7IP | 9811 | NP_060649.3 | yeast 2-hybrid | 15231748 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Jak-STAT signaling pathway | hsa04630 |
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam14324 | 128-278 | PINIT |
| cl16800 | 128-278 | PINIT superfamily |
| pfam02891 | 323-371 | zf-MIZ |
| cl17238 | 323-371 | RING superfamily |
| smart00513 | Nov-36 | SAP |
| cl02640 | Nov-36 | SAP superfamily |
| COG5222 | 305-383 | COG5222 |
Ontology Information
| HPRD ID | 2761 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.