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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16491830 | 2005 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 26 Stage : - | real time RT-PCR | Down-regulation | - | CDX1 and CDX2 mRNA expressions were found to be significantly reduced in colorectal cancers. |
| 15378566 | 2004 | Cell line : - Source : Pusan National University Hospital. Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 48 Stage : - | real time RT-PCR,LOH analyses, PCR amplification of bisulphite-treated DNA | Methylation | - | CDX1 promoter hypermethylation is one of the molecular mechanisms that accounts for reduced CDX1 gene expression in colorectal carcinoma. |
| 23618814 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Methylation-specific PCR | Methylation | - | ROS-induced oxidative stress silences the tumor suppressor CDX1 through epigenetic regulation, and may therefore be associated with the progression of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : HOXL subclass |
| Description | This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q32 |
| Start | 149546344 |
| End | 149564121 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 17778 |
| OMIM ID | 600746 |
| HGNC ID | HGNC:1805 |
| Unigene ID | Hs.1545 |
| Ensembl ID | ENSG00000113722 |
| PharmGKB ID | PA26351 |
mRNA Information
| mRNA ID | NM_001804.2 |
|---|---|
| Exon | join(1..541,15988..16133,16694..17778) | mRNA Sequence | Download Select all |
| Length | 1772 |
Protein Information
| Protein ID | NP_001795.2 |
|---|---|
| Protein Name | caudal type homeobox 1 |
| Molecular Wt. (Da) | 28007 |
| Protein Sequence | Download Select all |
| Length | 265 |
| Uniprot ID | P01111 |
| Ensembl Protein ID | ENSP00000358548 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1050 | CEBPA | 296 | NP_004355.2 | in vitro | 19059241 |
| 51176 | LEF1 | 1075 | NP_057353.1 | in vitro;in vivo | 15143193 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 156-211 | homeodomain |
| cl00084 | 156-211 | homeodomain superfamily |
| pfam00046 | 156-211 | Homeobox |
| smart00389 | 156-210 | HOX |
| pfam04731 | 13-142 | Caudal_act |
| cl22486 | 13-142 | Caudal_act superfamily |
| COG5576 | 158-211 | COG5576 |
Ontology Information
| HPRD ID | 1095 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.