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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18587323 | 2008 | Cell line : - Source : Institute of Pathology, University Hospital of Basel, Switzerland, the Institute of Clinical Pathology, Basel Switzerland and the Institute of Pathology, Stadtspital Triemli, Z?rich, Switzerland. Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry of Tissue Microarray, Mismatch Repair Status analysis. | Down-regulation | - | Loss of CDX2 and CK20 is more frequently encountered in mismatch repair-deficient colorectal cancer, which should be taken into consideration to differentiate between primary and metastatic colorectal cancer. |
| 21626348 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | MTT assay, Flow cytometry. | Down-regulation | - | CDX2 may play a critical role in the migration and metastasis of colon carcinoma and over-expression of CDX2 in colon cancer cells markedly inhibits invasion. Exogenous expression of CDX2 might be a promising option in the treatment of colon carcinoma. Human colon cancer cell line, Lovo were used in this study. |
| 22202456 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Expression profiling analysis | Down-regulation | - | Loss of Cdx2 expression in colon cancer cells might reduce expression of Mucdhl and thereby lead to tumor formation. |
| 22547830 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Flow cytometry, Western blotting, immunohistochemistry, phase-contrast microscopy. | Down-regulation | - | A significant link between sLe(x/a) expression and EMT in colon cancer cells and a pivotal role of c-Myc and CDX2 in regulating sLe(x/a) expression during EMT. ST3GAL1/3/4 and FUT3 are transcriptionally up-regulated by c-Myc with probable involvement of Ser62 phosphorylation, and that FUT2 is transcriptionally down-regulated through the attenuation of CDX2. Human colon cancer cell lines, HT29 and DLD-1, were used. |
| 22849325 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray analysis | Down-regulation | - | Identified miR-9, miR-16 and miR-22 as having the potential to suppress Cdx2 through the binding of the 3'UTR to its transcript, simultaneous mutations of both the miR-9- and miR-16-binding sites in the CDX2 3'UTR were shown to be sufficient to block Cdx2 suppression. |
| 22986531 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Down-regulation | - | Downregulation of HNF4 is an important determinant of the reduced expression of the Cdx2 tumor suppressor gene in intestinal cancers. Cdx2, HNF4 exerts a tumor suppressor function in the colon in that its loss of function facilitates tumor progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : HOXL subclass |
| Description | This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012] |
| Chromosome | 13 |
| Location | 13q12.3 |
| Start | 27960057 |
| End | 27969368 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9312 |
| OMIM ID | 600297 |
| HGNC ID | HGNC:1806 |
| Unigene ID | Hs.174249 |
| Ensembl ID | ENSG00000165556 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011534875.1 |
|---|---|
| Exon | join(32..903,4330..4499,6000..9312) | mRNA Sequence | Download Select all |
| Length | 2370 |
CDS Information
| Location | join(363..903,4354..4499,6000..6254) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS9328.1 |
Protein Information
| Protein ID | NP_001256.3 |
|---|---|
| Protein Name | Caudal type homeobox 2 |
| Molecular Wt. (Da) | 33379 |
| Protein Sequence | Download Select all |
| Length | 313 |
| Uniprot ID | O94778 |
| Ensembl Protein ID | ENSP00000219660 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 60 |
| S | Phosphorylation | 283 |
| S | Phosphorylation | 287 |
| S | Phosphorylation | 291 |
| S | Phosphorylation | 295 |
| S | Phosphorylation | 283 |
| S | Phosphorylation | 287 |
| S | Phosphorylation | 291 |
| S | Phosphorylation | 295 |
| S | Phosphorylation | 283 |
| S | Phosphorylation | 287 |
| S | Phosphorylation | 291 |
| S | Phosphorylation | 295 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 39 | ACAT2 | 6 | NP_005882.2 | in vivo | 12518221 |
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro | 19117933 |
| 1432 | MAPK14 | 2619 | NP_001306.1 | in vitro | 16027724 |
| 2932 | GSK3B | 5418 | NP_002084.2 | in vitro | 16027724 |
| 5594 | MAPK1 | 1496 | NP_002736.3 | in vitro | 16027724 |
| 6927 | HNF1A | 800 | NP_000536.5 | in vitro;in vivo | 10677375 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 188-243 | homeodomain |
| cl00084 | 188-243 | homeodomain superfamily |
| pfam04731 | 13-180 | Caudal_act |
| cl22486 | 13-180 | Caudal_act superfamily |
| pfam00046 | 188-243 | Homeobox |
| smart00389 | 188-242 | HOX |
| COG5576 | 178-248 | COG5576 |
Ontology Information
| HPRD ID | 4778 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Water channel activity (GO:0015250) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.