Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| VAV3 | 10451 | vav 3 guanine nucleotide exchange factor | 1 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25791293 | 2015 | Cell line : - Source : - Sample Type : Population basedcCase control study No. of Sample : 354 Stage : - | - | Up-regulation | - | VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Rho guanine nucleotide exchange factors, "Pleckstrin homology (PH) domain containing", "SH2 domain containing" |
| Description | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1p13.3 |
| Start | 108113782 |
| End | 108507545 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 393764 |
| OMIM ID | 605541 |
| HGNC ID | HGNC:12659 |
| Unigene ID | Hs.267659 |
| Ensembl ID | ENSG00000134215 |
| PharmGKB ID | PA37282 |
Protein Information
| Protein ID | NP_001073343.1 |
|---|---|
| Protein Name | vav 3 guanine nucleotide exchange factor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 847 |
| Uniprot ID | Q9Y4R7 |
| Ensembl Protein ID | ENSP00000373338 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 387 | RHOA | 1323 | NP_001655.1 | in vitro | 10523675 |
| 391 | RHOG | 1537 | NP_001656.2 | in vitro | 10523675 |
| 1956 | EGFR | 579 | NP_005219.2 | in vivo | 11094073 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 11094073 |
| 3480 | IGF1R | 932 | NP_000866.1 | in vivo | 11094073 |
| 3643 | INSR | 975 | NP_000199.2 | in vivo | 11094073 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vitro;in vivo | 11094073 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vitro;in vivo | 11094073 |
| 5879 | RAC1 | 3627 | NP_061485.1 | in vitro | 10523675 |
| 6098 | ROS1 | 1295 | NP_002935.2 | in vivo;yeast 2-hybrid | 11094073 |
| 6464 | SHC1 | 2780 | NP_001123512.1 | in vivo | 11094073 |
| 7791 | ZYX | 3592 | NP_003452.1 | in vitro;yeast 2-hybrid | 8622875 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| B cell receptor signaling pathway | hsa04662 |
| cAMP signaling pathway | hsa04024 |
| Chemokine signaling pathway | hsa04062 |
| Fc epsilon RI signaling pathway | hsa04664 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Focal adhesion | hsa04510 |
| Leukocyte transendothelial migration | hsa04670 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Regulation of actin cytoskeleton | hsa04810 |
| T cell receptor signaling pathway | hsa04660 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10407 | 666-768 | SH2_Vav3 |
| cl15255 | 666-768 | SH2 superfamily |
| cd01223 | 383-506 | PH_Vav |
| cl17171 | 383-506 | PH-like superfamily |
| cd00160 | 193-369 | RhoGEF |
| cl02571 | 193-369 | RhoGEF superfamily |
| cd11981 | 596-657 | SH3_VAV3_1 |
| cl17036 | 596-657 | SH3 superfamily |
| cd11978 | 791-846 | SH3_VAV3_2 |
| cl17036 | 791-846 | SH3 superfamily |
| cd00014 | 2-118 | CH |
| cl00030 | 2-118 | CH superfamily |
| cd00029 | 514-561 | C1 |
| cl00040 | 514-561 | C1 superfamily |
| cd09940 | 666-766 | SH2_Vav_family |
| smart00325 | 196-370 | RhoGEF |
| pfam00621 | 196-370 | RhoGEF |
| cd10406 | 666-767 | SH2_Vav2 |
| cd10405 | 666-768 | SH2_Vav1 |
| cd11831 | 596-657 | SH3_VAV_1 |
| cd11830 | 792-845 | SH3_VAV_2 |
| pfam11971 | 18-103 | CAMSAP_CH |
| cd11977 | 791-846 | SH3_VAV2_2 |
| smart00252 | 670-751 | SH2 |
| cd11976 | 792-845 | SH3_VAV1_2 |
| cd11979 | 596-657 | SH3_VAV1_1 |
| cd00173 | 671-746 | SH2 |
| cd11766 | 792-845 | SH3_Nck_2 |
| cd09942 | 670-770 | SH2_nSH2_p85_like |
| cd11980 | 596-657 | SH3_VAV2_1 |
| cd11823 | 795-845 | SH3_Nostrin |
| pfam00017 | 672-746 | SH2 |
| smart00326 | 793-844 | SH3 |
| pfam00307 | 4-118 | CH |
| cd11877 | 795-845 | SH3_PIX |
| cd09930 | 672-765 | SH2_cSH2_p85_like |
| cd00174 | 792-842 | SH3 |
| cd11809 | 793-843 | SH3_srGAP |
| cd11781 | 793-845 | SH3_Sorbs_1 |
| pfam07653 | 798-845 | SH3_2 |
| cd11805 | 795-845 | SH3_GRB2_like_C |
| smart00033 | 30-115 | CH |
| cd09935 | 671-765 | SH2_ABL |
| cd11901 | 793-845 | SH3_Nck1_2 |
| cd12060 | 792-845 | SH3_alphaPIX |
| cd09943 | 670-747 | SH2_Nck_family |
| cd11842 | 793-845 | SH3_Ysc84p_like |
| cd11919 | 793-844 | SH3_Sorbs1_1 |
| cd11840 | 794-845 | SH3_Intersectin_5 |
| pfam00018 | 794-840 | SH3_1 |
| cd12061 | 795-845 | SH3_betaPIX |
| cd09933 | 670-750 | SH2_Src_family |
| cd11902 | 793-846 | SH3_Nck2_2 |
| cd11839 | 790-844 | SH3_Intersectin_4 |
| cd09941 | 671-750 | SH2_Grb2_like |
| pfam00130 | 514-562 | C1_1 |
| pfam14604 | 795-844 | SH3_9 |
| cd11956 | 793-843 | SH3_srGAP4 |
| cd10408 | 670-747 | SH2_Nck1 |
| cd11771 | 795-845 | SH3_Pex13p_fungal |
| cd09932 | 670-751 | SH2_C-SH2_PLC_gamma_like |
| cd11883 | 792-842 | SH3_Sdc25 |
| cd12059 | 793-843 | SH3_MLK1-3 |
| cd09931 | 672-753 | SH2_C-SH2_SHP_like |
| cd10370 | 670-750 | SH2_Src_Src42 |
| smart00109 | 514-562 | C1 |
| cd11836 | 795-844 | SH3_Intersectin_1 |
| cd10402 | 671-747 | SH2_C-SH2_Zap70 |
| cd12142 | 806-844 | SH3_D21-like |
| cd10409 | 672-747 | SH2_Nck2 |
| cd11762 | 795-845 | SH3_FCHSD_2 |
| cd11856 | 794-845 | SH3_p47phox_like |
| cd11873 | 793-845 | SH3_CD2AP-like_1 |
| cd11951 | 795-843 | SH3_GRAP_C |
| cd11920 | 793-845 | SH3_Sorbs2_1 |
| cd11804 | 793-843 | SH3_GRB2_like_N |
| cd10365 | 670-750 | SH2_Src_Src |
| cd09945 | 670-751 | SH2_SHB_SHD_SHE_SHF_like |
| smart00233 | 407-502 | PH |
| cd11875 | 797-845 | SH3_CD2AP-like_3 |
| cd11793 | 793-845 | SH3_ephexin1_like |
| cd11827 | 795-845 | SH3_MyoIe_If_like |
| cd11921 | 793-844 | SH3_Vinexin_1 |
| cd09937 | 668-747 | SH2_csk_like |
| cd12058 | 795-843 | SH3_MLK4 |
| cd11772 | 795-845 | SH3_OSTF1 |
| cd11995 | 794-844 | SH3_Intersectin1_5 |
| cd11946 | 793-844 | SH3_GRB2_N |
| cd11828 | 793-843 | SH3_ARHGEF9_like |
| cd11996 | 794-844 | SH3_Intersectin2_5 |
| cd10369 | 670-750 | SH2_Src_Frk |
| cd11876 | 795-845 | SH3_MLK |
| cd11759 | 801-844 | SH3_CRK_C |
| cd10348 | 672-746 | SH2_Cterm_shark_like |
| cd11959 | 792-844 | SH3_Cortactin |
| cd09923 | 671-747 | SH2_SOCS_family |
| pfam07653 | 596-657 | SH3_2 |
| cd11837 | 793-845 | SH3_Intersectin_2 |
| cd11782 | 793-844 | SH3_Sorbs_2 |
| cd11824 | 793-844 | SH3_PSTPIP1 |
| cd11832 | 794-841 | SH3_Shank |
| cd11841 | 792-843 | SH3_SH3YL1_like |
| cd10358 | 670-756 | SH2_PTK6_Brk |
| cd11763 | 795-845 | SH3_SNX9_like |
| cd10391 | 670-771 | SH2_SHE |
| cd11874 | 797-845 | SH3_CD2AP-like_2 |
| cd10360 | 671-746 | SH2_Srm |
| cd11812 | 794-843 | SH3_AHI-1 |
| cd12052 | 793-845 | SH3_CIN85_1 |
| cd11949 | 795-844 | SH3_GRB2_C |
| cd11894 | 795-845 | SH3_FCHSD2_2 |
| cd11955 | 793-843 | SH3_srGAP1-3 |
| cd11826 | 794-844 | SH3_Abi |
| cd09929 | 670-751 | SH2_BLNK_SLP-76 |
| cd10340 | 672-753 | SH2_N-SH2_SHP_like |
| cd12046 | 794-845 | SH3_p67phox_C |
| cd11817 | 793-842 | SH3_Eve1_4 |
| cd10361 | 670-751 | SH2_Fps_family |
| cd10401 | 671-748 | SH2_C-SH2_Syk_like |
| cd10341 | 670-752 | SH2_N-SH2_PLC_gamma_like |
| cd09925 | 670-751 | SH2_SHC |
| cd11843 | 795-844 | SH3_PACSIN |
| pfam00169 | 407-502 | PH |
| cd11884 | 793-844 | SH3_MYO15 |
| cd11778 | 795-842 | SH3_Bzz1_2 |
| cd11964 | 795-846 | SH3_STAM1 |
| cd12057 | 801-844 | SH3_CIN85_3 |
| cd11960 | 793-844 | SH3_Abp1_eu |
| cd12012 | 792-845 | SH3_RIM-BP_2 |
| cd11895 | 792-845 | SH3_FCHSD1_2 |
| cd01224 | 408-497 | PH_Collybistin_ASEF |
| cd11858 | 795-845 | SH3_Myosin-I_fungi |
| cd11851 | 792-845 | SH3_RIM-BP |
| cd10418 | 672-746 | SH2_Src_Fyn_isoform_a_like |
| cd11950 | 793-844 | SH3_GRAP2_C |
| cd11825 | 795-845 | SH3_PLCgamma |
| cd11987 | 795-845 | SH3_Intersectin1_1 |
| cd11806 | 792-843 | SH3_PRMT2 |
| cd11829 | 797-843 | SH3_GAS7 |
| cd11819 | 793-844 | SH3_Cortactin_like |
| cd10367 | 672-746 | SH2_Src_Fgr |
| cd10368 | 672-746 | SH2_Src_Fyn |
| cd12076 | 794-845 | SH3_Tks4_2 |
| cd12053 | 794-845 | SH3_CD2AP_1 |
| cd11786 | 793-844 | SH3_SH3RF_1 |
| cd10363 | 670-747 | SH2_Src_HCK |
| cd11923 | 791-844 | SH3_Sorbs2_2 |
| cd10345 | 671-747 | SH2_C-SH2_Zap70_Syk_like |
| cd11982 | 806-840 | SH3_Shank1 |
| cd12054 | 797-845 | SH3_CD2AP_2 |
| cd10343 | 670-765 | SH2_SHIP |
| cd11988 | 795-845 | SH3_Intersectin2_1 |
| cd12141 | 795-843 | SH3_DNMBP_C2 |
| cd11890 | 792-847 | MIA |
| cd11833 | 794-843 | SH3_Stac_1 |
| cd11803 | 795-844 | SH3_Endophilin_A |
| cd09938 | 671-769 | SH2_N-SH2_Zap70_Syk_like |
| cd10353 | 672-750 | SH2_Nterm_RasGAP |
| cd12073 | 793-844 | SH3_HS1 |
| cd09944 | 670-747 | SH2_Grb7_family |
| cd10354 | 671-746 | SH2_Cterm_RasGAP |
| cd10366 | 670-750 | SH2_Src_Yes |
| cd11947 | 793-844 | SH3_GRAP2_N |
| cd11948 | 793-844 | SH3_GRAP_N |
| cd11800 | 794-842 | SH3_DNMBP_C2_like |
| cd13243 | 354-446 | PH_PLEKHG1_G2_G3 |
| cd11855 | 793-844 | SH3_Sho1p |
| cd10352 | 673-743 | SH2_a2chimerin_b2chimerin |
| cd10412 | 668-747 | SH2_SH2B3 |
| cd11784 | 794-843 | SH3_SH3RF2_3 |
| cd12009 | 794-843 | SH3_Blk |
| cd11768 | 792-845 | SH3_Tec_like |
| cd10347 | 672-746 | SH2_Nterm_shark_like |
| cd10392 | 670-751 | SH2_SHF |
| cd11760 | 793-847 | SH3_MIA_like |
| cd11961 | 793-845 | SH3_Abp1_fungi_C2 |
| cd11970 | 795-845 | SH3_PLCgamma1 |
| cd12021 | 793-844 | SH3_p47phox_1 |
| cd12055 | 795-845 | SH3_CIN85_2 |
| cd12017 | 794-845 | SH3_Tks_3 |
| cd11969 | 795-845 | SH3_PLCgamma2 |
| cd11963 | 795-846 | SH3_STAM2 |
| cd12013 | 794-845 | SH3_RIM-BP_3 |
| cd11770 | 794-845 | SH3_Nephrocystin |
| cd10419 | 672-750 | SH2_Src_Fyn_isoform_b_like |
| cd11796 | 806-843 | SH3_DNMBP_N3 |
| cd10337 | 666-788 | SH2_BCAR3 |
| cd10388 | 672-752 | SH2_SOCS7 |
| cd11764 | 792-844 | SH3_Eps8 |
| cd12056 | 806-843 | SH3_CD2AP_3 |
| cd10344 | 657-746 | SH2_SLAP |
| cd10389 | 670-771 | SH2_SHB |
| cd11975 | 781-843 | SH3_ARHGEF9 |
| cd10387 | 670-752 | SH2_SOCS6 |
| cd11816 | 793-843 | SH3_Eve1_3 |
| cd10355 | 672-746 | SH2_DAPP1_BAM32_like |
| cd12015 | 792-844 | SH3_Tks_1 |
| cd10362 | 670-750 | SH2_Src_Lck |
| cd11974 | 793-843 | SH3_ASEF2 |
| cd11779 | 795-844 | SH3_Irsp53_BAIAP2L |
| cd11820 | 795-843 | SH3_STAM |
| cd10399 | 672-750 | SH2_Tec_Bmx |
| cd10410 | 671-751 | SH2_SH2B1 |
| cd11985 | 794-844 | SH3_Stac2_C |
| cd11989 | 793-844 | SH3_Intersectin1_2 |
| cd11897 | 793-844 | SH3_SNX18 |
| cd11906 | 794-845 | SH3_BTK |
| cd11808 | 794-844 | SH3_Alpha_Spectrin |
| cd11990 | 801-844 | SH3_Intersectin2_2 |
| cd09934 | 672-750 | SH2_Tec_family |
| cd11775 | 792-844 | SH3_Sla1p_3 |
| cd11971 | 794-844 | SH3_Abi1 |
| cd11993 | 799-844 | SH3_Intersectin1_4 |
| cd09926 | 672-765 | SH2_CRK_like |
| cd11815 | 793-844 | SH3_Eve1_2 |
| cd10411 | 671-751 | SH2_SH2B2 |
| cd11896 | 793-844 | SH3_SNX33 |
| cd11864 | 792-844 | SH3_PEX13_eumet |
| cd10356 | 670-743 | SH2_ShkA_ShkC |
| cd11941 | 794-843 | SH3_ARHGEF37_C2 |
| cd11813 | 793-844 | SH3_SGSM3 |
| cd11769 | 794-845 | SH3_CSK |
| cd10346 | 668-749 | SH2_SH2B_family |
| smart00326 | 593-656 | SH3 |
| cd11935 | 795-844 | SH3_Nebulette_C |
| cd11991 | 794-843 | SH3_Intersectin1_3 |
| cd11973 | 780-843 | SH3_ASEF |
| cd11922 | 791-844 | SH3_Sorbs1_2 |
| cd11758 | 794-845 | SH3_CRK_N |
| cd11838 | 794-845 | SH3_Intersectin_3 |
| cd10371 | 670-746 | SH2_Src_Blk |
| cd12044 | 806-843 | SH3_SKAP1 |
| cd11972 | 794-844 | SH3_Abi2 |
| cd11789 | 794-844 | SH3_Nebulin_family_C |
| cd12016 | 794-844 | SH3_Tks_2 |
| cd11940 | 799-845 | SH3_ARHGEF5_19 |
| cd11845 | 792-842 | SH3_Src_like |
| cd11850 | 794-843 | SH3_Abl |
| cd11928 | 795-844 | SH3_SH3RF3_1 |
| cd11929 | 793-844 | SH3_SH3RF2_1 |
| cd11984 | 806-843 | SH3_Shank3 |
| cd12014 | 806-844 | SH3_RIM-BP_1 |
| cd11997 | 795-844 | SH3_PACSIN3 |
| cd11994 | 792-844 | SH3_Intersectin2_4 |
| cd11866 | 795-843 | SH3_SKAP1-like |
| cd11869 | 793-844 | SH3_p40phox |
| cd12007 | 792-843 | SH3_Yes |
| cd11821 | 795-842 | SH3_ASAP |
| cd11938 | 799-845 | SH3_ARHGEF16_26 |
| cd11992 | 794-843 | SH3_Intersectin2_3 |
| cd10414 | 670-747 | SH2_Grb14 |
| cd11998 | 795-844 | SH3_PACSIN1-2 |
| cd10390 | 670-751 | SH2_SHD |
| cd12045 | 806-843 | SH3_SKAP2 |
| cd11882 | 793-844 | SH3_GRAF-like |
| cd10382 | 675-746 | SH2_SOCS1 |
| cd11818 | 795-842 | SH3_Eve1_5 |
| cd11927 | 793-844 | SH3_SH3RF1_1 |
| cd11962 | 793-844 | SH3_Abp1_fungi_C1 |
| cd11914 | 807-844 | SH3_BAIAP2L2 |
| cd11844 | 792-844 | SH3_CAS |
| cd11933 | 795-844 | SH3_Nebulin_C |
| cd11983 | 806-843 | SH3_Shank2 |
| cd11835 | 790-843 | SH3_ARHGAP32_33 |
| cd11785 | 806-844 | SH3_SH3RF_C |
| cd11905 | 792-845 | SH3_Tec |
| cd11886 | 792-842 | SH3_BOI |
| cd12009 | 610-657 | SH3_Blk |
| cd10398 | 672-750 | SH2_Tec_Txk |
| cd10397 | 672-750 | SH2_Tec_Btk |
| cd12003 | 792-844 | SH3_EFS |
| cd11870 | 794-844 | SH3_p67phox-like_C |
| cd10351 | 671-747 | SH2_SH2D4B |
| cd11892 | 795-847 | SH3_MIA2 |
| smart00557 | 682-720 | IG_FLMN |
| cl19759 | 682-720 | Filamin superfamily |
| cd12047 | 794-843 | SH3_Noxa1_C |
| cd11939 | 799-845 | SH3_ephexin1 |
| cd11952 | 791-842 | SH3_iASPP |
| cd11891 | 790-845 | MIAL |
| cd12024 | 806-842 | SH3_NoxO1_2 |
| cd10386 | 671-721 | SH2_SOCS5 |
| cd11924 | 791-844 | SH3_Vinexin_2 |
| cd10383 | 672-746 | SH2_SOCS2 |
| cd11765 | 792-843 | SH3_Nck_1 |
| cd11889 | 795-843 | SH3_Cyk3p-like |
| cd00821 | 414-497 | PH |
| cd11986 | 794-843 | SH3_Stac3_1 |
| cd13387 | 404-495 | PH1_FGD3 |
| cd11899 | 792-844 | SH3_Nck2_1 |
| cd11767 | 792-845 | SH3_Nck_3 |
| cd12000 | 792-840 | SH3_CASS4 |
| cd11872 | 790-843 | SH3_DOCK_AB |
| pfam00630 | 681-720 | Filamin |
| COG5199 | 32-117 | SCP1 |
Ontology Information
| HPRD ID | 8406 |
|---|---|
| Molecular Class | Guanine nucleotide exchange factor |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.