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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GPNMB | 10457 | glycoprotein (transmembrane) nmb | 7 | NMB, HGFIN |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19750230 | 2009 | Cell line : - Source : Hospitals of Shiraz University of Medical Sciences Sample Type : CRC tumor and normal tissue No. of Sample : 152 Stage : - | Methylation specific PCR,chi-square analysis, tissue microarrays, immunohistochemistry | Methylation | - | A significantly higher methylation rate was found for GPNMB, ICAM5, and CHD5 genes in AA patients compared to Iranians. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7p |
| Start | 23286305 |
| End | 23314729 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 28425 |
| OMIM ID | 604368 |
| HGNC ID | HGNC:4462 |
| Unigene ID | Hs.190495 |
| Ensembl ID | ENSG00000136235 |
| PharmGKB ID | PA28845 |
Protein Information
| Protein ID | NP_001005340.1 |
|---|---|
| Protein Name | glycoprotein (transmembrane) nmb |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 572 |
| Uniprot ID | Q99417 |
| Ensembl Protein ID | ENSP00000380702 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00146 | 256-319 | PKD |
| cl09101 | 256-319 | E_set superfamily |
| smart00089 | 262-319 | PKD |
| pfam00801 | 277-315 | PKD |
| TIGR00864 | 204-317 | PCC |
| TIGR00864 | 232-319 | PCC |
Ontology Information
| HPRD ID | 8462 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.