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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23541221 | 2013 | Cell line : - Source : Canada and Australian Population Sample Type : Population basedcCase control study. No. of Sample : 2695 CRC cases and 4593 controls Stage : - | - | Mutation | - | This report is the first to suggest a risk of CRC associated with mutations in the HOXB13 gene. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : HOXL subclass |
| Description | This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21.32 |
| Start | 46802125 |
| End | 46806111 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3987 |
| OMIM ID | 604607 |
| HGNC ID | HGNC:5112 |
| Unigene ID | Hs.66731 |
| Ensembl ID | ENSG00000159184 |
| PharmGKB ID | PA29388 |
Protein Information
| Protein ID | NP_006352.2 |
|---|---|
| Protein Name | homeobox B13 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 284 |
| Uniprot ID | Q96EP5 |
| Ensembl Protein ID | ENSP00000233078 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4211 | MEIS1 | 3442 | NP_002389.1 | in vitro | 9343407 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 217-273 | homeodomain |
| cl00084 | 217-273 | homeodomain superfamily |
| pfam00046 | 217-273 | Homeobox |
| smart00389 | 216-272 | HOX |
| pfam12284 | 10-123 | HoxA13_N |
| cl13688 | 10-123 | HoxA13_N superfamily |
| COG5576 | 214-284 | COG5576 |
Ontology Information
| HPRD ID | 7048 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.