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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CARM1 10498 coactivator-associated arginine methyltransferase 1  19PRMT4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21478268   2011Cell line : HT29, HCT116 ,CaCo2, Lovo,SW620,DLD1, RKO

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Cell culture, luciferase reporter assay, GST-pull down, chromatin immunoprecipitation, real time RT-PCR, cell proliferation assay and colony formation assay.Up-regulation-CARM1 is an important positive modulator of Wnt/?-catenin transcription and neoplastic transformation, and may thereby represent a novel target for therapeutic intervention in cancers involving aberrantly activated Wnt/?-catenin signaling.


Gene Details



NC_000019.9 (10982253..11033453)

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Gene Type protein coding
Gene Family Protein arginine methyltransferases
Description This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]  
Chromosome 19
Location 19p13.2
Start 10982253  
End 11033453  
Strand +  
Gene Sequence

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Length 51201  
OMIM ID 603934   
HGNC ID HGNC:23393   
Unigene ID Hs.323213   
Ensembl ID ENSG00000142453   
PharmGKB ID PA134959553   

mRNA Information


mRNA ID ?NM_199141.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS12250.1



Protein Information


      
Protein IDNP_954592.1
Protein Namecoactivator-associated arginine methyltransferase 1
Molecular Wt. (Da)0
Protein Sequence

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Length 608  
Uniprot IDQ96EZ4
Ensembl Protein ID ENSP00000308330  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1387CREBBP2534NP_004371.2in vitro;in vivo12374746   
1994ELAVL116025NP_001410.2in vitro;in vivo12237300   
2033EP3004078NP_001420.2in vivo15616592   
2314FLII2647NP_002009.1in vitro;in vivo;yeast 2-hybrid14966289   
3020H3F3A3082NP_002098.1in vitro11751582   
5970RELA1241NP_068810.3in vitro;in vivo15616592   
8648NCOA14070NP_003734.3in vitro10381882   
10499NCOA29066NP_006531.1in vitro10381882   
23637RABGAP16575NP_036329.3in vivo17124247   
26986PABPC15247NP_002559.2in vitro;in vivo11850402   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1333030-139  PH_CARM1
cl1717130-139  PH-like superfamily
cd02440188-283  AdoMet_MTases
cl17173188-283  AdoMet_MTases superfamily
pfam1153128-139  CARM1
pfam05185172-435  PRMT5
pfam05175174-286  MTS
pfam12847184-286  Methyltransf_18
pfam13649188-283  Methyltransf_25
COG4076157-287  COG4076
pfam08241189-256  Methyltransf_11
COG2263179-258  COG2263
pfam13659188-283  Methyltransf_26
PRK07580177-246  PRK07580
PRK14968169-312  PRK14968
PRK14896176-256  ksgA
PRK15068172-260  PRK15068
COG0742176-283  RsmD
TIGR00452177-283  TIGR00452
TIGR01444187-231  fkbM_fam
pfam08003172-317  Methyltransf_9
pfam08242189-283  Methyltransf_12
COG3897174-302  Nnt1
COG4123186-258  TrmN6
PRK00517169-213  prmA
pfam06325184-283  PrmA
COG2227171-286  UbiG
TIGR00406182-283  prmA
COG2264182-255  PrmA
pfam13847184-283  Methyltransf_31
COG2230184-293  Cfa
COG2890184-258  HemK
COG2813174-286  RsmC
PRK05134176-286  PRK05134
COG1189164-257  YqxC
COG0500184-394  SmtA
COG2519183-283  Gcd14
COG2520185-285  Trm5
TIGR02072175-256  BioC
TIGR00478166-225  tly
TIGR00536174-326  hemK_fam
COG2242184-285  CobL
pfam02475185-261  Met_10


Ontology Information


   
HPRD ID9404
Molecular ClassEnzyme: Methyltransferase
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO