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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NCOA2 10499 nuclear receptor coactivator 2  8TIF2, GRIP1, NCoA-2, KAT13C, bHLHe75 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25823027   2015Cell line : CaCO2, DLD 1, HCT116, LoVo, LS180, SW480, SW620, SW1116

Source : The Prince of Wales Hospital. Cells purchased from the American Type Culture Collection.

Sample Type : -

No. of Sample : -

Stage : TNM Stage III,IV

Whole-genome sequencing and SV calling,real time RT-PCR,Western blotting,Flow cytometry, colony formation assay,tumorigenicity assaysDown-regulation-NCOA2 is a novel negative growth regulatory gene repressing the Wnt/?-catenin pathway in CRC.


Gene Details



NC_000008.10 (71021997..71316062, complement)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-acetyltransferases, "Basic helix-loop-helix proteins"
Description The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]  
Chromosome 8
Location 8q13.3
Start 71021997  
End 71316062  
Strand -  
Gene Sequence

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Length 294066  
OMIM ID 601993   
HGNC ID HGNC:7669   
Unigene ID Hs.446678   
Ensembl ID ENSG00000140396   
PharmGKB ID PA31471   

mRNA Information


mRNA ID ?NM_006540.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS47872.1



Protein Information


      
Protein IDNP_006531.1
Protein Namenuclear receptor coactivator 2
Molecular Wt. (Da)0
Protein Sequence

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Length 1464  
Uniprot IDO60565
Ensembl Protein ID ENSP00000300177  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation699;-
SPhosphorylation493;-
SPhosphorylation736
SPhosphorylation29
SPhosphorylation565
SAcetylation2
SPhosphorylation716
KAcetylation780
KAcetylation785
KAcetylation640
KAcetylation636
SPhosphorylation698
SPhosphorylation469
SPhosphorylation474
SPhosphorylation487
SPhosphorylation471
SPhosphorylation499
SPhosphorylation668
TPhosphorylation681
SPhosphorylation851
TPhosphorylation854
SPhosphorylation721
TPhosphorylation722
SPhosphorylation726
TPhosphorylation729
TPhosphorylation456

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
88ACTN219NP_001094.1in vitro15072553   
367AR2437NP_000035.2in vitro;in vivo;yeast 2-hybrid97   178   431   258   898   700   000   000   
405ARNT524NP_001659.1in vivo12024042   
896CCND3452NP_001751.1in vivo12130539   
1019CDK4447NP_000066.1in vivo12130539   
1499CTNNB1286NP_001895.1in vivo12588987   
1746DLX2527NP_004396.1in vivo;yeast 2-hybrid11675124   
1749DLX52492NP_005212.1in vivo11675124   
2099ESR1589NP_000116.2in vitro11937504   
2103ESRRB3700NP_004443.3in vitro10598588   
2908NR3C1679NP_001019265.1in vitro12151000   
3091HIF1A4517NP_001521.1in vitro10594042   
3164NR4A1744NP_002126.2in vitro12082103   
3172HNF4A2612CAA89989.1in vitro;in vivo;yeast 2-hybrid9812974   
3276PRMT14257NP_001527.3in vitro11050077   
3799KIF5B7214NP_004512.1in vivo;yeast 2-hybrid11986669   
4208MEF2C2809NP_002388.2in vivo12130539   
5468PPARG3288NP_056953.2in vitro;yeast 2-hybrid10944516   
5956OPN1LW2366NP_064445.1in vitro;in vivo9430642   
6095RORA2896NP_599022.1in vitro;yeast 2-hybrid10478845   
6256RXRA1577NP_002948.1in vitro119   810   341   074   817   000   000   000   
6605SMARCE14382NP_003070.3in vitro12145209   
7068THRB7521NP_000452.2in vitro12612084   
7080NKX2-12798NP_001073136.1in vitro10617585   
7421VDR3463NP_000367.1in vitro;in vivo;yeast 2-hybrid120   893   461   279   648   000   000   000   
7533YWHAH215NP_003396.1in vitro11266503   
10521DDX1710532NP_001091974.1in vitro;yeast 2-hybrid11250900   


Pathway Information


      
Pathway Name Pathway ID
Thyroid hormone signaling pathway hsa04919


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00130123-213  PAS
cl21578123-213  PAS superfamily
cd0008329-88  HLH
cl0008129-88  HLH superfamily
pfam08832638-709  SRC-1
cl07440638-709  SRC-1 superfamily
pfam074691281-1338  DUF1518
cl064851281-1338  DUF1518 superfamily
pfam088151071-1116  Nuc_rec_co-act
cl074271071-1116  Nuc_rec_co-act superfamily
smart00091118-175  PAS
smart0035335-88  HLH
pfam14598268-379  PAS_11
pfam13426127-213  PAS_9
pfam097701133-1380  PAT1
pfam00989119-215  PAS
pfam096061140-1453  Med15
COG51801269-1399  PBP1
pfam097701103-1339  PAT1
pfam09606971-1405  Med15
pfam097701025-1239  PAT1
TIGR00229119-213  sensory_box


Ontology Information


   
HPRD ID7018
Molecular ClassTranscription regulatory protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
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Cancer3DGO
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NCGGO
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Tumor Gene Family of DatabasesGO
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