Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
IPO8 10526 Importin 8  12RANBP8 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : CRC tumor and normal tissue

No. of Sample : 8

Stage : -

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation2.2-


Gene Details



Chromosome: 12; NC_000012.11 (30781915..30848929, complement)

View Larger Image
   
Gene Type protein coding
Gene Family Importins
Description The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]  
Chromosome 12
Location 12p11.21
Start 30628981  
End 30695995  
Strand +  
Gene Sequence

   Download   Select all

Length 67015  
OMIM ID 605600   
HGNC ID HGNC:9853   
Unigene ID Hs.505136    
Ensembl ID ENSG00000133704   
PharmGKB ID -   

mRNA Information


mRNA ID NM_006390.3
Exon join(1..432,5419..5500,11539..11695,14179..14337, 15358..15514,19409..19498,21243..21337,21922..22006, 24900..25034,26714..26813,29745..29821,30151..30267, 30687..30776,32342..32507,33509..33669,34730..34855, 39246..39312,42904..43029,43707..43804,46764..46859, 56261..56481,58809..59014,61710..61913,63985..64101, 65039..67015)  
mRNA Sequence

   Download   Select all

Length 5365  



CDS Information


   
Locationjoin(349..432,5419..5500,11539..11695,14179..14337, 15358..15514,19409..19498,21243..21337,21922..22006, 24900..25034,26714..26813,29745..29821,30151..30267, 30687..30776,32342..32507,33509..33669,34730..34855, 39246..39312,42904..43029,43707..43804,46764..46859, 56261..56481,58809..59014,61710..61913,63985..64101, 65039..65136)
CDS Sequence

   Download   Select all

CCDS ID CCDS8719.1



Protein Information


      
Protein IDNP_001177924.1
Protein NameImportin 8
Molecular Wt. (Da)95906
Protein Sequence

   Download   Select all

Length 832  
Uniprot IDP07992
Ensembl Protein ID ENSP00000013807  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation902
SPhosphorylation903
SPhosphorylation389
TPhosphorylation908

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3837KPNB14114NP_002256.2in vitro9214382   
5905RANGAP13839NP_002874.1in vitro9214382   
6728SRP191644NP_003126.1in vitro11682607   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0381022-101  IBN_N
cl0427122-101  IBN_N superfamily
smart0091322-102  IBN_N
pfam08506195-441  Cse1
cl20359195-441  Cse1 superfamily
COG565615-996  SXM1
COG56571-678  CSE1


Ontology Information


   
HPRD ID595
Molecular ClassTransport/cargo protein
Molecular FunctionDNA repair protein (GO:0003685)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO