Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 2.2 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Importins |
| Description | The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]   |
| Chromosome | 12 |
| Location | 12p11.21 |
| Start | 30628981   |
| End | 30695995   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 67015   |
| OMIM ID | 605600    |
| HGNC ID | HGNC:9853    |
| Unigene ID | Hs.505136     |
| Ensembl ID | ENSG00000133704    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_006390.3 |
|---|---|
| Exon | join(1..432,5419..5500,11539..11695,14179..14337, 15358..15514,19409..19498,21243..21337,21922..22006, 24900..25034,26714..26813,29745..29821,30151..30267, 30687..30776,32342..32507,33509..33669,34730..34855, 39246..39312,42904..43029,43707..43804,46764..46859, 56261..56481,58809..59014,61710..61913,63985..64101, 65039..67015)   | mRNA Sequence |    Download   Select all |
| Length | 5365   |
CDS Information
| Location | join(349..432,5419..5500,11539..11695,14179..14337, 15358..15514,19409..19498,21243..21337,21922..22006, 24900..25034,26714..26813,29745..29821,30151..30267, 30687..30776,32342..32507,33509..33669,34730..34855, 39246..39312,42904..43029,43707..43804,46764..46859, 56261..56481,58809..59014,61710..61913,63985..64101, 65039..65136) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS8719.1 |    
Protein Information
| Protein ID | NP_001177924.1 |
|---|---|
| Protein Name | Importin 8 |
| Molecular Wt. (Da) | 95906 |
| Protein Sequence |    Download   Select all |
| Length | 832   |
| Uniprot ID | P07992 |    
| Ensembl Protein ID | ENSP00000013807   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 902 |
| S | Phosphorylation | 903 |
| S | Phosphorylation | 389 |
| T | Phosphorylation | 908 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3837 |    KPNB1 |    4114 |    NP_002256.2 |    in vitro |    9214382    |
| 5905 |    RANGAP1 |    3839 |    NP_002874.1 |    in vitro |    9214382    |
| 6728 |    SRP19 |    1644 |    NP_003126.1 |    in vitro |    11682607    |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03810 | 22-101  | IBN_N |
| cl04271 | 22-101  | IBN_N superfamily |
| smart00913 | 22-102  | IBN_N |
| pfam08506 | 195-441  | Cse1 |
| cl20359 | 195-441  | Cse1 superfamily |
| COG5656 | 15-996  | SXM1 |
| COG5657 | 1-678  | CSE1 |
Ontology Information
| HPRD ID | 595 |    
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
