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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 14 primary colorectal cancers with liver metastases, and 11 non-metastatic carcinomas and 9 adenomas Stage : TNM Stage I-IV | Biochemical isolation to nano-LC-MS/MS analysis | Unknown | - | - |
| 14719106 | 2004 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : TNM Stage II | real time RT- PCR | Up-regulation | - | PRDX4, CKS2, MAGED2, and an EST were expressed at significantly higher levels in tumors with metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008] |
| Chromosome | X |
| Location | Xp22.11 |
| Start | 23664260 |
| End | 23686399 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 22140 |
| OMIM ID | 606506 |
| HGNC ID | HGNC:17169 |
| Unigene ID | Hs.83383 |
| Ensembl ID | ENSG00000123131 |
| PharmGKB ID | PA33725 |
mRNA Information
| mRNA ID | XM_005274438.1 |
|---|---|
| Exon | join(1..459,7270..7387,10731..10847,14906..15028, 18137..18267,19412..19446,22026..22140) | mRNA Sequence | Download Select all |
| Length | 1098 |
CDS Information
| Location | join(261..459,7270..7387,10731..10847,14906..15028, 18137..18267,19412..19446,22026..22076) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_006397.1 |
|---|---|
| Protein Name | Peroxiredoxin 4 |
| Molecular Wt. (Da) | 26572 |
| Protein Sequence | Download Select all |
| Length | 271 |
| Uniprot ID | O14944 |
| Ensembl Protein ID | ENSP00000244869 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 1.11.1.15 |
|---|---|
| Name | peroxiredoxin thioredoxin peroxidase tryparedoxin peroxidase alkyl hydroperoxide reductase C22 AhpC TrxPx TXNPx Prx PRDX |
| Class | Oxidoreductases; Acting on a peroxide as acceptor; Peroxidases |
| Sysname | thiol-containing-reductant:hydroperoxide oxidoreductase |
| Substrate | R'-SH [CPD:C16736]; ROOH |
| Product | R'-S-S-R' [CPD:C15496]; H2O [CPD:C00001]; ROH |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5052 | PRDX1 | 1458 | NP_002565.1 | in vitro;in vivo;yeast 2-hybrid | 9388242 |
| 8458 | TTF2 | 5280 | NP_003585.3 | yeast 2-hybrid | 12927788 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03015 | 81-252 | PRX_Typ2cys |
| cl00388 | 81-252 | Thioredoxin_like superfamily |
| cd02971 | 93-229 | PRX_family |
| pfam00578 | 81-214 | AhpC-TSA |
| cd03016 | 102-269 | PRX_1cys |
| COG1225 | 99-236 | Bcp |
| cd03018 | 80-230 | PRX_AhpE_like |
| cd03017 | 99-230 | PRX_BCP |
| pfam08534 | 80-224 | Redoxin |
| pfam10417 | 234-269 | 1-cysPrx_C |
| cl22976 | 234-269 | 1-cysPrx_C superfamily |
| cd03014 | 92-218 | PRX_Atyp2cys |
| PRK09437 | 95-214 | bcp |
| COG2077 | 80-218 | Tpx |
| PRK00522 | 93-206 | tpx |
| COG0450 | 81-269 | AhpC |
| PTZ00253 | 79-267 | PTZ00253 |
| PRK15000 | 81-267 | PRK15000 |
| TIGR03137 | 81-264 | AhpC |
| PTZ00137 | 81-269 | PTZ00137 |
| PRK13189 | 105-262 | PRK13189 |
| PRK10382 | 81-264 | PRK10382 |
| PRK13190 | 103-261 | PRK13190 |
| PRK13191 | 101-256 | PRK13191 |
| PRK13599 | 105-249 | PRK13599 |
Ontology Information
| HPRD ID | 1298 |
|---|---|
| Molecular Class | Enzyme: Peroxidase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.