Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCT2 | 10576 | chaperonin containing TCP1, subunit 2 (beta) | 12 | Cctb |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11795471 | 2001 | Cell line : - Source : Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine. Sample Type : CRC tumor and normal tissue No. of Sample : 32 Stage : - | Western blotting,Immunohistochemistry | Up-regulation | - | Results suggest that CCT is up-regulated in rapidly proliferating tumor cells in vivo to effectively produce proteins required for growth, and may serve as a useful tumor marker because it is widely distributed in the cytosol. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Heat Shock Proteins / Chaperonins |
| Description | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| Chromosome | 12 |
| Location | 12q15 |
| Start | 69979206 |
| End | 70010595 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 31390 |
| OMIM ID | 605139 |
| HGNC ID | HGNC:1615 |
| Unigene ID | Hs.189772 |
| Ensembl ID | ENSG00000166226 |
| PharmGKB ID | PA26179 |
Protein Information
| Protein ID | NP_001185771.1 |
|---|---|
| Protein Name | chaperonin containing TCP1, subunit 2 (beta) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 535 |
| Uniprot ID | Q9Y5S8 |
| Ensembl Protein ID | ENSP00000217885 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 154 |
| K | Acetylation | 13 |
| K | Acetylation | 181 |
| S | Phosphorylation | 260 |
| S | Phosphorylation | 3 |
| S | Phosphorylation | 115 |
| S | Phosphorylation | 143 |
| S | Phosphorylation | 150 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 | ACTB | 32 | NP_001092.1 | in vitro;in vivo | 1 074 820 911 580 260 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03336 | 11-527 | TCP1_beta |
| cl02777 | 11-527 | chaperonin_like superfamily |
| PTZ00212 | 5-530 | PTZ00212 |
| TIGR02341 | 10-528 | chap_CCT_beta |
| cd00309 | 16-522 | chaperonin_type_I_II |
| pfam00118 | 35-525 | Cpn60_TCP1 |
| COG0459 | 13-530 | GroEL |
| cd03343 | 9-524 | cpn60 |
| cd03340 | 8-523 | TCP1_eta |
| cd03335 | 22-525 | TCP1_alpha |
| TIGR02345 | 8-523 | chap_CCT_eta |
| TIGR02340 | 15-527 | chap_CCT_alpha |
| cd03339 | 8-522 | TCP1_epsilon |
| cd03338 | 17-521 | TCP1_delta |
| TIGR02343 | 24-522 | chap_CCT_epsi |
| cd03337 | 8-521 | TCP1_gamma |
| TIGR02342 | 17-524 | chap_CCT_delta |
| cd03341 | 35-523 | TCP1_theta |
| TIGR02344 | 8-527 | chap_CCT_gamma |
| TIGR02346 | 10-525 | chap_CCT_theta |
| TIGR02347 | 9-528 | chap_CCT_zeta |
| cd03342 | 16-523 | TCP1_zeta |
| cd03333 | 156-403 | chaperonin_like |
| cd03344 | 31-515 | GroEL |
| PTZ00114 | 31-515 | PTZ00114 |
| PRK12849 | 37-153 | groEL |
| TIGR02348 | 22-163 | GroEL |
| PRK00013 | 37-147 | groEL |
| PLN03167 | 31-136 | PLN03167 |
| CHL00093 | 39-135 | groEL |
| cd03334 | 320-398 | Fab1_TCP |
| TIGR02339 | 8-523 | thermosome_arch |
| PRK12850 | 24-530 | groEL |
| PRK12851 | 31-531 | groEL |
| PRK12852 | 14-534 | groEL |
| PRK14104 | 24-527 | PRK14104 |
Ontology Information
| HPRD ID | 3714 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.