Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| POSTN | 10631 | periostin, osteoblast specific factor | 13 | OSF-2, PN, periostin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24173294 | 2014 | Cell line : - Source : Shanghai, China (training cohort) and Guangzhou, China (validation cohort). Sample Type : Population based case-control study No. of Sample : 682 cases and 343 controls Stage : - | Immunohistochemistry | Up-regulation | - | - |
| 26023718 | 2015 | Cell line : - Source : Department of General Surgery, Qilu Hospital of Shandong University. Sample Type : CRC tumor and normal tissue No. of Sample : 133 Stage : - | Immunohistochemistry | Up-regulation | - | Patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015 |
| Chromosome | 13 |
| Location | 13q13.3 |
| Start | 38136719 |
| End | 38172981 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 36263 |
| OMIM ID | 608777 |
| HGNC ID | HGNC:16953 |
| Unigene ID | Hs.136348 |
| Ensembl ID | ENSG00000133110 |
| PharmGKB ID | PA134900304 |
Protein Information
| Protein ID | NP_001129406.1 |
|---|---|
| Protein Name | periostin, osteoblast specific factor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 836 |
| Uniprot ID | Q15327 |
| Ensembl Protein ID | ENSP00000360762 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02469 | 245-367 | Fasciclin |
| cl02663 | 245-367 | Fasciclin superfamily |
| pfam02469 | 507-630 | Fasciclin |
| cl02663 | 507-630 | Fasciclin superfamily |
| pfam02469 | 109-230 | Fasciclin |
| cl02663 | 109-230 | Fasciclin superfamily |
| smart00554 | 270-367 | FAS1 |
| smart00554 | 133-230 | FAS1 |
| pfam02469 | 382-494 | Fasciclin |
| cl02663 | 382-494 | Fasciclin superfamily |
| smart00554 | 532-630 | FAS1 |
| smart00554 | 404-494 | FAS1 |
| pfam07546 | 40-87 | EMI |
| cl06535 | 40-87 | EMI superfamily |
| COG2335 | 237-367 | FAS1 |
| COG2335 | 505-635 | FAS1 |
| COG2335 | 119-230 | FAS1 |
| COG2335 | 368-496 | FAS1 |
Ontology Information
| HPRD ID | 10783 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.