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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| IGF2BP3 | 10643 | insulin-like growth factor 2 mRNA binding protein 3 | 7 | IMP-3, CT98, IMP3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22840368 | 2012 | Cell line : - Source : The Nurses Health Study (N=121,701 women followed since 1976), and the Health Professionals Follow-up Study (N=51,529 men followed since 1986) Sample Type : CRC tumor and normal tissue No. of Sample : 671 rectal and colon cancer cases Stage : TNM Stage I-IV | Pyrosequencing, immunohistochemistry | Up-regulation | - | IGF2BP3 as a diagnostic and/or prognostic biomarker in colorectal cancer. Among 671 colorectal cancers, 234 (35%) tumours were positive for IGF2BP3. In contrast, normal colorectal epithelium was negative for IGF2BP3 in all 403 specimens of normal mucosa adjacent to carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RNA binding motif (RRM) containing |
| Description | The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. |
| Chromosome | 7 |
| Location | 7p15.3 |
| Start | 23310209 |
| End | 23470527 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 160319 |
| OMIM ID | 608259 |
| HGNC ID | HGNC:28868 |
| Unigene ID | Hs.700696 |
| Ensembl ID | ENSG00000136231 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011515089.1 |
|---|---|
| Exon | join(1..592,1986..2046,51704..51752,67943..67957, 108787..108838,108931..108994,118942..119223, 122794..122928,124466..124588,126675..126810, 128339..128464,151274..151390,152815..152889, 156875..157006,157680..157793,158068..160319) | mRNA Sequence | Download Select all |
| Length | 4168 |
CDS Information
| Location | join(418..592,1986..2046,51704..51752,108787..108838, 108931..108994,118942..119223,122794..122928, 124466..124588,126675..126810,128339..128464, 151274..151390,152815..152889,156875..157006, 157680..157793,158068..158166) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5382.1 |
Protein Information
| Protein ID | NP_006538.2 |
|---|---|
| Protein Name | insulin-like growth factor 2 mRNA binding protein 3 |
| Molecular Wt. (Da) | 63574 |
| Protein Sequence | Download Select all |
| Length | 579 |
| Uniprot ID | P05107 |
| Ensembl Protein ID | ENSP00000303242 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 184 |
| S | Phosphorylation | 187 |
| T | Phosphorylation | 528 |
| S | Phosphorylation | 571 |
| S | Phosphorylation | 243 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2.00E+44 |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | Insulin-like growth factor 2 mRNA binding protein 3 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd12630 | 81-156 | RRM2_IGF2BP3 |
| cl17169 | 81-156 | RRM_SF superfamily |
| cd12627 | Jan-77 | RRM1_IGF2BP3 |
| cl17169 | Jan-77 | RRM_SF superfamily |
| cd00105 | 279-344 | KH-I |
| cl00098 | 279-344 | KH-I superfamily |
| cd02396 | 407-470 | PCBP_like_KH |
| cl00098 | 407-470 | KH-I superfamily |
| cd00105 | 198-261 | KH-I |
| cl00098 | 198-261 | KH-I superfamily |
| cd00105 | 489-554 | KH-I |
| cl00098 | 489-554 | KH-I superfamily |
| cd12628 | 81-156 | RRM2_IGF2BP1 |
| cd12625 | Jan-77 | RRM1_IGF2BP1 |
| cd12359 | 81-156 | RRM2_VICKZ |
| cd12629 | 81-156 | RRM2_IGF2BP2 |
| cd12358 | Apr-77 | RRM1_VICKZ |
| cd12626 | Jan-77 | RRM1_IGF2BP2 |
| smart00322 | 275-347 | KH |
| cd00105 | 407-470 | KH-I |
| pfam00013 | 279-343 | KH_1 |
| smart00322 | 487-557 | KH |
| cd00590 | 83-151 | RRM_SF |
| smart00322 | 198-264 | KH |
| cd02396 | 198-261 | PCBP_like_KH |
| cd00590 | Apr-71 | RRM_SF |
| pfam00013 | 198-260 | KH_1 |
| pfam00013 | 489-553 | KH_1 |
| pfam00013 | 407-470 | KH_1 |
| cd02396 | 279-343 | PCBP_like_KH |
| pfam00076 | Apr-69 | RRM_1 |
| smart00322 | 406-474 | KH |
| cd02396 | 491-554 | PCBP_like_KH |
| cd12343 | Mar-71 | RRM1_2_CoAA_like |
| cd12608 | Mar-73 | RRM1_CoAA |
| pfam00076 | 85-150 | RRM_1 |
| pfam13014 | 287-331 | KH_3 |
| cd12650 | 83-153 | RRM1_Hu |
| cd12609 | Mar-71 | RRM2_CoAA |
| cd12399 | Mar-70 | RRM_HP0827_like |
| cd02394 | 274-344 | vigilin_like_KH |
| cd12375 | 81-153 | RRM1_Hu_like |
| pfam13014 | 499-541 | KH_3 |
| cd12239 | Feb-71 | RRM2_RBM40_like |
| pfam13014 | 417-458 | KH_3 |
| cd12373 | Mar-73 | RRM_SRSF3_like |
| pfam13014 | 206-246 | KH_3 |
| cd02395 | 286-312 | SF1_like-KH |
| cd12337 | Mar-73 | RRM1_SRSF4_like |
| cd12447 | Mar-73 | RRM1_gar2 |
| cd12361 | Mar-70 | RRM1_2_CELF1-6_like |
| cd12414 | Mar-74 | RRM2_RBM28_like |
| cd12392 | 82-152 | RRM2_SART3 |
| cd12382 | Feb-73 | RRM_RBMX_like |
| cd12649 | 124-153 | RRM1_SXL |
| cd12340 | 82-153 | RBD_RRM1_NPL3 |
| cd02394 | 202-261 | vigilin_like_KH |
| cd12594 | Mar-77 | RRM1_SRSF4 |
| cd12772 | 83-153 | RRM1_HuC |
| cd12524 | Apr-76 | RRM1_MEI2_like |
| cd12306 | May-70 | RRM_II_PABPs |
| pfam13893 | 103-153 | RRM_5 |
| cd12771 | 83-153 | RRM1_HuB |
| cd12399 | 82-151 | RRM_HP0827_like |
| cd12439 | 80-151 | RRM_TRMT2A |
| cd12770 | 83-153 | RRM1_HuD |
| cd12298 | Mar-71 | RRM3_Prp24 |
| cd12408 | 124-151 | RRM_eIF3G_like |
| cd12284 | 83-151 | RRM2_RBM23_RBM39 |
| cd12398 | May-73 | RRM_CSTF2_RNA15_like |
| cd12613 | Apr-70 | RRM2_NGR1_NAM8_like |
| cd12599 | Apr-71 | RRM1_SF2_plant_like |
| cd12675 | Feb-76 | RRM2_Nop4p |
| cd12435 | 83-149 | RRM_GW182_like |
| cd12450 | Apr-71 | RRM1_NUCLs |
| cd12251 | Apr-70 | RRM3_hnRNPR_like |
| cd12284 | Apr-70 | RRM2_RBM23_RBM39 |
| cd12612 | Apr-76 | RRM2_SECp43 |
| cd12251 | 83-151 | RRM3_hnRNPR_like |
| cd02393 | 202-262 | PNPase_KH |
| cd12596 | Mar-73 | RRM1_SRSF6 |
| cd12389 | 83-155 | RRM2_RAVER |
| cd12392 | Feb-75 | RRM2_SART3 |
| cd12336 | Apr-71 | RRM_RBM7_like |
| cd12409 | Mar-75 | RRM1_RRT5 |
| cd12412 | Feb-76 | RRM_DAZL_BOULE |
| cd12606 | Mar-71 | RRM1_RBM4 |
| cd12413 | Apr-76 | RRM1_RBM28_like |
| cd12254 | Apr-70 | RRM_hnRNPH_ESRPs_RBM12_like |
| cd12273 | Apr-71 | RRM1_NEFsp |
| smart00360 | Mar-70 | RRM |
| smart00360 | 82-151 | RRM |
| TIGR01628 | 38-141 | PABP-1234 |
| TIGR01659 | 38-140 | sex-lethal |
| PRK13763 | 202-348 | PRK13763 |
| TIGR01661 | 38-141 | ELAV_HUD_SF |
| COG0724 | Feb-87 | RRM |
| TIGR01622 | 8-156 | SF-CC1 |
| pfam14259 | Apr-69 | RRM_6 |
| PRK13763 | 407-563 | PRK13763 |
| pfam14259 | 83-150 | RRM_6 |
| TIGR03665 | 409-564 | arCOG04150 |
| TIGR01628 | 4-155 | PABP-1234 |
| COG0724 | 71-151 | RRM |
| PRK11824 | 202-263 | PRK11824 |
| COG1094 | 198-348 | Krr1 |
| TIGR01622 | Mar-72 | SF-CC1 |
| COG5176 | 272-312 | MSL5 |
| TIGR01661 | 83-153 | ELAV_HUD_SF |
| TIGR03591 | 202-296 | polynuc_phos |
| pfam14611 | 210-314 | SLS |
| TIGR01628 | 4-153 | PABP-1234 |
| COG1185 | 202-296 | Pnp |
| PRK13764 | 453-542 | PRK13764 |
| PRK08406 | 417-511 | PRK08406 |
Ontology Information
| HPRD ID | 946 |
|---|---|
| Molecular Class | Translation regulatory protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165); Cell migration (GO:0016477); Cell adhesion (GO:0007155); Wound healing (GO:0042060) |
Drug Information
No matching records could be found.