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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MASP2 | 10747 | mannan-binding lectin serine peptidase 2 | 1 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15370690 | 2004 | Cell line : - Source : - Sample Type : Serum samples No. of Sample : 193 CRC and150 healthy volunteers Stage : - | Immunofluorometric assays | Up-regulation | - | MBL/MASP activity was significantly (P < 0.0002) increased in patients (584 (202-914) mU/mL) compared with in blood donors. |
| 15746044 | 2005 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 605 Stage : - | - | Up-regulation | - | In the cohort of patients with colorectal cancer investigated, MASP-2 concentration in serum proved to be an independent prognostic marker with high MASP-2 levels predicting recurrence and poor survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] |
| Chromosome | 1 |
| Location | 1p36.3-p36 |
| Start | 11086580 |
| End | 11107296 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 20717 |
| OMIM ID | 605102 |
| HGNC ID | HGNC:6902 |
| Unigene ID | Hs.655645 |
| Ensembl ID | ENSG00000009724 |
| PharmGKB ID | PA30645 |
Protein Information
| Protein ID | NP_006601.2 |
|---|---|
| Protein Name | mannan-binding lectin serine peptidase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 686 |
| Uniprot ID | Q9UBT3 |
| Ensembl Protein ID | ENSP00000220812 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2220 | FCN2 | 3376 | NP_004099.2 | in vitro | 12421953 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| Staphylococcus aureus infection | hsa05150 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 445-682 | Tryp_SPc |
| cl21584 | 445-682 | Tryp_SPc superfamily |
| cd00041 | 184-295 | CUB |
| cl00049 | 184-295 | CUB superfamily |
| cd00041 | 11-136 | CUB |
| cl00049 | 11-136 | CUB superfamily |
| cd00033 | 300-361 | CCP |
| cl00043 | 300-361 | CCP superfamily |
| cd00054 | 138-175 | EGF_CA |
| cl21504 | 138-175 | EGF_CA superfamily |
| cd00033 | 366-431 | CCP |
| cl00043 | 366-431 | CCP superfamily |
| pfam00431 | 184-293 | CUB |
| smart00042 | 194-293 | CUB |
| smart00042 | 28-134 | CUB |
| pfam00431 | 28-134 | CUB |
| smart00032 | 300-361 | CCP |
| pfam00084 | 300-361 | Sushi |
| pfam14670 | 152-180 | FXa_inhibition |
| smart00179 | 138-176 | EGF_CA |
| pfam00084 | 366-430 | Sushi |
| pfam07645 | 138-180 | EGF_CA |
| smart00032 | 366-430 | CCP |
| smart00020 | 444-679 | Tryp_SPc |
| pfam00089 | 445-679 | Trypsin |
| COG5640 | 444-680 | COG5640 |
| PHA02817 | 300-430 | PHA02817 |
| PHA02927 | 287-433 | PHA02927 |
Ontology Information
| HPRD ID | 6943 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.