Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADCY2 | 108 | adenylate cyclase 2 (brain) | 5 | HBAC2, KIAA1060, AC2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25815774 | 2015 | Cell line : - Source : Metastatic colorectal cancer patients from the CAIRO trial. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 268 Stage : TNM Stage IV | - | Polymorhpism | - | In patients receiving capecitabine monotherapy, rs4702484, located in ADCY2 and close to MTRR, was associated with slightly reduced PFS for homozygous wild-type patients. Germline DNA was collected for 268 metastatic colorectal cancer patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Adenylate cyclases |
| Description | This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5p15.3 |
| Start | 7396343 |
| End | 7830194 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 433852 |
| OMIM ID | 103071 |
| HGNC ID | HGNC:233 |
| Unigene ID | Hs.481545 |
| Ensembl ID | ENSG00000078295 |
| PharmGKB ID | PA24561 |
mRNA Information
| mRNA ID | NM_020546.2 |
|---|---|
| Exon | join(1..277,18344..18541,124509..124670,229938..230087, 294462..294610,299523..299634,302018..302145, 310515..310673,311477..311609,312982..313158, 316627..316670,320928..321008,328316..328385, 330935..331032,347439..347523,361220..361357, 370458..370577,376703..376872,388136..388220, 393413..393571,405989..406135,408356..408463, 420637..420751,424336..424460,430490..433852) | mRNA Sequence | Download Select all |
| Length | 6553 |
Protein Information
| Protein ID | NP_065433.2 |
|---|---|
| Protein Name | adenylate cyclase 2 (brain) |
| Molecular Wt. (Da) | 123473 |
| Protein Sequence | Download Select all |
| Length | 1091 |
| Uniprot ID | Q15796 |
| Ensembl Protein ID | ENSP00000262160 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adrenergic signaling in cardiomyocytes | hsa04261 |
| Aldosterone synthesis and secretion | hsa04925 |
| Bile secretion | hsa04976 |
| Calcium signaling pathway | hsa04020 |
| cAMP signaling pathway | hsa04024 |
| cGMP-PKG signaling pathway | hsa04022 |
| Chemokine signaling pathway | hsa04062 |
| Cholinergic synapse | hsa04725 |
| Circadian entrainment | hsa04713 |
| Dilated cardiomyopathy | hsa05414 |
| Estrogen signaling pathway | hsa04915 |
| GABAergic synapse | hsa04727 |
| Gap junction | hsa04540 |
| Gastric acid secretion | hsa04971 |
| Glucagon signaling pathway | hsa04922 |
| Glutamatergic synapse | hsa04724 |
| GnRH signaling pathway | hsa04912 |
| HTLV-I infection | hsa05166 |
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| Insulin secretion | hsa04911 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Melanogenesis | hsa04916 |
| Morphine addiction | hsa05032 |
| Oocyte meiosis | hsa04114 |
| Ovarian steroidogenesis | hsa04913 |
| Oxytocin signaling pathway | hsa04921 |
| Pancreatic secretion | hsa04972 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| Platelet activation | hsa04611 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Purine metabolism | hsa00230 |
| Rap1 signaling pathway | hsa04015 |
| Regulation of lipolysis in adipocytes | hsa04923 |
| Retrograde endocannabinoid signaling | hsa04723 |
| Salivary secretion | hsa04970 |
| Thyroid hormone synthesis | hsa04918 |
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07302 | 288-463 | CHD |
| cl11967 | 288-463 | Nucleotidyl_cyc_III superfamily |
| cd07302 | 886-1076 | CHD |
| cl11967 | 886-1076 | Nucleotidyl_cyc_III superfamily |
| pfam00211 | 878-1077 | Guanylate_cyc |
| pfam00211 | 281-465 | Guanylate_cyc |
| cd07556 | 885-1041 | Nucleotidyl_cyc_III |
| cd07556 | 288-426 | Nucleotidyl_cyc_III |
| pfam06327 | 495-600 | DUF1053 |
| cl05691 | 495-600 | DUF1053 superfamily |
| smart00044 | 236-439 | CYCc |
| smart00044 | 848-1056 | CYCc |
| COG2114 | 283-493 | AcyC |
| COG2114 | 851-1069 | AcyC |
Ontology Information
| HPRD ID | 4380 |
|---|---|
| Molecular Class | Adenylate cyclase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.