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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PPP1R13L 10848 protein phosphatase 1, regulatory subunit 13 like  19RAI, IASPP 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23180017   2013Cell line : -

Source : -

Sample Type : Fresh frozen normal tissue

No. of Sample : 349 CRC patients

Stage : -

PCR-restriction fragment length polymorphism (PCR-RFLP).Polymorhpism-The present results suggest that the PPP1R13L rs1970764 variant is a possible prognostic marker for patients with rectal cancer.


Gene Details



NC_000019.9 (45882892..45909787, complement)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]  
Chromosome 19
Location 19q13.32
Start 45882892  
End 45909787  
Strand -  
Gene Sequence

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Length 26896  
OMIM ID 607463   
HGNC ID HGNC:18838   
Unigene ID Hs.466937   
Ensembl ID ENSG00000104881   
PharmGKB ID PA34195   

mRNA Information


mRNA ID ?NM_001142502.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS33050.1



Protein Information


      
Protein IDNP_001135974.1
Protein Nameprotein phosphatase 1, regulatory subunit 13 like
Molecular Wt. (Da)0
Protein Sequence

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Length 828  
Uniprot IDQ53GG5
Ensembl Protein ID ENSP00000284770  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation567;-
SPhosphorylation81
SPhosphorylation102
SPhosphorylation526
SPhosphorylation110
SPhosphorylation113
SPhosphorylation119
SPhosphorylation120
TPhosphorylation123
YPhosphorylation132
SPhosphorylation134
SPhosphorylation158
SPhosphorylation594
SPhosphorylation597
SPhosphorylation183
SPhosphorylation187
SPhosphorylation203
SPhosphorylation225
YPhosphorylation211
SPhosphorylation220
SPhosphorylation280
SPhosphorylation316
SPhosphorylation332
SPhosphorylation357
SPhosphorylation358
SPhosphorylation395
YPhosphorylation109
SPhosphorylation152
TPhosphorylation241
TPhosphorylation341
SPhosphorylation53
SPhosphorylation84

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5499PPP1CA15942NP_001008709.1yeast 2-hybrid15231748   
5970RELA1241NP_068810.3in vitro;in vivo;yeast 2-hybrid1   213   400   710   336   460   
6667SP11796NP_612482.2in vitro;in vivo12134007   
7157TP531859NP_000537.3in vitro12524540   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11952761-817  SH3_iASPP
cl17036761-817  SH3 superfamily
cd00204626-748  ANK
cl02529626-748  ANK superfamily
cd11807761-817  SH3_ASPP
cd11954761-817  SH3_ASPP1
cd11953761-817  SH3_ASPP2
cd00204657-748  ANK
cd00204607-713  ANK
cd00174763-814  SH3
smart00326763-814  SH3
pfam14604765-814  SH3_9
cd11845765-814  SH3_Src_like
cd11800763-816  SH3_DNMBP_C2_like
cd11856764-814  SH3_p47phox_like
cd12003765-819  SH3_EFS
cd11844765-813  SH3_CAS
cd11847765-814  SH3_Brk
cd11840763-814  SH3_Intersectin_5
cd11812763-814  SH3_AHI-1
cd12000765-813  SH3_CASS4
cd11947765-814  SH3_GRAP2_N
cd11806763-816  SH3_PRMT2
cd11772763-815  SH3_OSTF1
cd11827765-814  SH3_MyoIe_If_like
cd11996761-817  SH3_Intersectin2_5
pfam00018765-811  SH3_1
cd12141764-816  SH3_DNMBP_C2
cd12001765-813  SH3_BCAR1
cd11995763-817  SH3_Intersectin1_5
cd11804765-814  SH3_GRB2_like_N
cd11805763-814  SH3_GRB2_like_C
cd11828765-811  SH3_ARHGEF9_like
cd11875765-814  SH3_CD2AP-like_3
cd11823765-814  SH3_Nostrin
cd12002765-818  SH3_NEDD9
cd11849765-814  SH3_SPIN90
cd11948765-817  SH3_GRAP_N
cd11946765-814  SH3_GRB2_N
cd11826763-814  SH3_Abi
cd11866765-814  SH3_SKAP1-like
cd11817765-814  SH3_Eve1_4
cd12006765-814  SH3_Fyn_Yrk
cd12007765-814  SH3_Yes
cd11809765-814  SH3_srGAP
cd11842765-814  SH3_Ysc84p_like
cd11778762-814  SH3_Bzz1_2
pfam07653765-814  SH3_2
cd11841763-814  SH3_SH3YL1_like
cd12009763-814  SH3_Blk
cd12058765-814  SH3_MLK4
cd11766763-814  SH3_Nck_2
cd11824765-817  SH3_PSTPIP1
cd11803765-814  SH3_Endophilin_A
cd11763763-814  SH3_SNX9_like
cd11949762-814  SH3_GRB2_C
cd11774763-814  SH3_Sla1p_2
cd11818765-814  SH3_Eve1_5
cd11950763-814  SH3_GRAP2_C
cd11877763-814  SH3_PIX
cd12059765-814  SH3_MLK1-3
cd11999763-814  SH3_PACSIN_like
cd00204687-731  ANK
cd11843763-814  SH3_PACSIN
cd11951763-814  SH3_GRAP_C
cd12073765-817  SH3_HS1
cd11819765-819  SH3_Cortactin_like
cd12005763-814  SH3_Lck
cd12004763-814  SH3_Lyn
cd11876765-814  SH3_MLK
cd11771765-814  SH3_Pex13p_fungal
cd11961763-814  SH3_Abp1_fungi_C2
cd12056765-814  SH3_CD2AP_3
cd11838765-814  SH3_Intersectin_3
cd11762763-811  SH3_FCHSD_2
cd11956765-817  SH3_srGAP4
cd11761765-814  SH3_FCHSD_1
cd12057766-818  SH3_CIN85_3
cd11820763-814  SH3_STAM
cd11837762-814  SH3_Intersectin_2
cd11821763-819  SH3_ASAP
cd11976765-814  SH3_VAV1_2
cd11770765-814  SH3_Nephrocystin
cd11796765-814  SH3_DNMBP_N3
cd12017764-816  SH3_Tks_3
cd12008762-814  SH3_Src
cd11894763-811  SH3_FCHSD2_2
pfam00023692-723  Ank
cd11773765-814  SH3_Sla1p_1
cd12142766-814  SH3_D21-like
cd11991765-814  SH3_Intersectin1_3
cd11904763-814  SH3_Nck1_3
cd11775765-814  SH3_Sla1p_3
cd12045766-814  SH3_SKAP2
cd11903763-814  SH3_Nck2_3
cd11974765-814  SH3_ASEF2
cd11905763-814  SH3_Tec
cd11767762-814  SH3_Nck_3
cd11901764-814  SH3_Nck1_2
cd11758763-814  SH3_CRK_N
cd12061763-814  SH3_betaPIX
pfam00023659-690  Ank
cd11765763-814  SH3_Nck_1
cd11963763-814  SH3_STAM2
cd11975765-818  SH3_ARHGEF9
cd11906763-814  SH3_BTK
cd11998763-814  SH3_PACSIN1-2
cd12060763-814  SH3_alphaPIX
cd11992765-814  SH3_Intersectin2_3
cd11902769-814  SH3_Nck2_2
cd12011765-814  SH3_SLAP2
cd11816765-814  SH3_Eve1_3
cd11911765-815  SH3_CIP4-like
cd12016769-814  SH3_Tks_2
cd11810762-814  SH3_RUSC1_like
cd11972763-814  SH3_Abi2
cd11768763-814  SH3_Tec_like
cd12074768-815  SH3_Tks5_1
cd12052767-814  SH3_CIN85_1
cd11964763-814  SH3_STAM1
cd11864765-814  SH3_PEX13_eumet
cd11882763-814  SH3_GRAF-like
cd11941763-814  SH3_ARHGEF37_C2
cd11990765-814  SH3_Intersectin2_2
cd11908763-815  SH3_ITK
cd11764766-813  SH3_Eps8
cd11878765-815  SH3_Bem1p_1
cd11955765-814  SH3_srGAP1-3
cd11966763-808  SH3_ASAP2
cd11808763-814  SH3_Alpha_Spectrin
cd11825762-814  SH3_PLCgamma
cd11935765-814  SH3_Nebulette_C
cd11887763-814  SH3_Bbc1
cd11969762-814  SH3_PLCgamma2
cd11888763-814  SH3_ARHGAP9_like
cd12022768-814  SH3_p47phox_2
cd12077769-815  SH3_Tks5_2
cd11920765-814  SH3_Sorbs2_1
cd11790763-819  SH3_Amphiphysin
cd11959765-814  SH3_Cortactin
cd12044765-815  SH3_SKAP1
cd11960765-819  SH3_Abp1_eu
cd11997763-814  SH3_PACSIN3
cd11802765-814  SH3_Endophilin_B
cd11830765-814  SH3_VAV_2
cd11971763-814  SH3_Abi1
cd11886765-821  SH3_BOI
cd12012765-813  SH3_RIM-BP_2
cd11989765-817  SH3_Intersectin1_2
cd11899763-814  SH3_Nck2_1
cd11835762-820  SH3_ARHGAP32_33
cd11973757-817  SH3_ASEF
cd11873763-814  SH3_CD2AP-like_1
pfam13606659-687  Ank_3
cd11836765-814  SH3_Intersectin_1
cd12015768-816  SH3_Tks_1
cd11874765-814  SH3_CD2AP-like_2
cd11884763-814  SH3_MYO15
smart00248659-687  ANK
smart00248692-721  ANK
cd12139763-800  SH3_Bin1
cd11986765-814  SH3_Stac3_1
cd12024764-814  SH3_NoxO1_2
cd11846765-814  SH3_Srms
cd11848765-814  SH3_SLAP-like
cd11912765-814  SH3_Bzz1_1
cd11858765-815  SH3_Myosin-I_fungi
cd11965763-818  SH3_ASAP1
cd11786765-814  SH3_SH3RF_1
cd11782765-814  SH3_Sorbs_2
cd11958762-814  SH3_RUSC1
pfam13606692-719  Ank_3
cd11885765-815  SH3_SH3TC
pfam12796631-722  Ank_2
COG0666617-731  ANKYR
pfam12796631-690  Ank_2
PHA03095652-731  PHA03095
PHA03095640-719  PHA03095
pfam13857651-700  Ank_5
PHA03100625-723  PHA03100
pfam13637662-709  Ank_4
PHA02875627-719  PHA02875
PHA02876662-726  PHA02876
PHA03095625-722  PHA03095
PHA03100656-719  PHA03100
COG0666630-793  ANKYR
PHA02878660-719  PHA02878
PHA0324775-507  PHA03247
PHA02878652-730  PHA02878
pfam13857679-732  Ank_5
pfam13637630-680  Ank_4
PHA02946643-736  PHA02946
PHA0330781-295  PHA03307
PHA0330764-366  PHA03307
PRK0776476-281  PRK07764
PHA02874634-719  PHA02874
PHA02876661-737  PHA02876
PHA02878664-711  PHA02878
PHA02798675-721  PHA02798
PRK12323141-345  PRK12323
PHA02874631-719  PHA02874
PRK0776460-237  PRK07764
PRK07764128-530  PRK07764
PHA02874657-708  PHA02874
PHA03100676-737  PHA03100


Ontology Information


   
HPRD ID5701
Molecular ClassTranslation regulatory protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO