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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CEACAM7 | 1087 | carcinoembryonic antigen-related cell adhesion molecule 7 | 19 | CEA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20004437 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 84 CRC which consisted of 37 patients with nonrecurrent disease , 29 patients with recurrent disease, and 18 patients with stage IV disease. Stage : TNM Stage I-IV | real time RT-PCR | Down-regulation | 21 Fold reduced expression | CEACAM-7 expression is significantly decreased in rectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / V-set domain containing, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| Chromosome | 19 |
| Location | 19q13.2 |
| Start | 42177235 |
| End | 42192196 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14962 |
| OMIM ID | - |
| HGNC ID | HGNC:1819 |
| Unigene ID | Hs.74466 |
| Ensembl ID | ENSG00000007306 |
| PharmGKB ID | PA26363 |
mRNA Information
| mRNA ID | NM_001291485.1 |
|---|---|
| Exon | join(1..176,1057..1419,4215..4493,10775..10902, 13539..14971) | mRNA Sequence | Download Select all |
| Length | 2379 |
Protein Information
| Protein ID | NP_001278414.1 |
|---|---|
| Protein Name | carcinoembryonic antigen-related cell adhesion molecule 7 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 265 |
| Uniprot ID | P21589 |
| Ensembl Protein ID | ENSP00000257770 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05774 | 38-141 | Ig_CEACAM_D1 |
| cl11960 | 38-141 | Ig superfamily |
| cd05740 | 147-234 | Ig_CEACAM_D4 |
| cl11960 | 147-234 | Ig superfamily |
| cd05741 | 48-141 | Ig_CEACAM_D1_like |
| cd04969 | 164-227 | Ig5_Contactin_like |
| cd05724 | 162-234 | Ig2_Robo |
| cd04969 | 97-122 | Ig5_Contactin_like |
| pfam13895 | 147-234 | Ig_2 |
| cd05752 | 161-234 | Ig1_FcgammaR_like |
| cd05876 | 164-226 | Ig3_L1-CAM |
| cd05757 | 99-137 | Ig2_IL1R_like |
| cd00096 | 164-223 | Ig |
| cd05852 | 164-230 | Ig5_Contactin-1 |
| cd00096 | 51-125 | Ig |
| pfam13927 | 147-220 | Ig_3 |
| cd05748 | 179-235 | Ig_Titin_like |
| pfam07679 | 141-234 | I-set |
| smart00410 | 164-234 | IG_like |
| smart00409 | 164-234 | IG |
| PHA02826 | 108-218 | PHA02826 |
| smart00408 | 164-223 | IGc2 |
Ontology Information
| HPRD ID | 1869 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Signal transduction (GO:0007165); Transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) |
Drug Information
No matching records could be found.