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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25129313 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 82 Stage : - | Tissue microarray, immunohistochemistry,RNA interference and ectopic expression | Up-regulation | - | FGL2 plays an important oncogenic role in CRC aggressiveness by inducing EMT. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibrinogen C domain containing |
| Description | The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7q11.23 |
| Start | 76822688 |
| End | 76829150 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6463 |
| OMIM ID | 605351 |
| HGNC ID | HGNC:3696 |
| Unigene ID | Hs.520989 |
| Ensembl ID | ENSG00000127951 |
| PharmGKB ID | PA28134 |
Protein Information
| Protein ID | NP_006673.1 |
|---|---|
| Protein Name | fibrinogen-like 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 439 |
| Uniprot ID | Q9NZL9 |
| Ensembl Protein ID | ENSP00000280969 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00087 | 210-435 | FReD |
| cl00085 | 210-435 | FReD superfamily |
| pfam00147 | 209-435 | Fibrinogen_C |
| smart00186 | 210-435 | FBG |
| pfam02994 | 24-188 | Transposase_22 |
| COG2433 | 28-161 | COG2433 |
Ontology Information
| HPRD ID | 4311 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.