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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RALBP1 10928 ralA binding protein 1  18RLIP76, RIP1, RIP 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17483352   2007Cell line : SW480

Source : Harlan

Sample Type : Athymic nude mice

No. of Sample : -

Stage : -

Immunohistochemistrys, TUNEL assayUp-regulation--

20706620   2010Cell line : -

Source : Tokyo Medical and Dental University Hospital Faculty of Medicine (Tokyo, Japan).

Sample Type : CRC tumor and normal tissue

No. of Sample : 79

Stage : -

Microarray Up-regulation-The combination of CNA and gene expression analysis, together with the clinical information, suggested UGT2B28, LOC440995, CXCL6, SULT1B1, RALBP1, TYMS, RAB12, RNMT, ARHGDIB, S1000A2, ABHD2, OIT3 and ABHD12 as genes that are possibly associated with CRC.

22549157   2011Cell line : -

Source : Department of Surgery, University of Heidelberg.

Sample Type : CRC tumor and normal tissue

No. of Sample : 78

Stage : Stage I,II,III, IV

Real-time RT-PCR, ELISAUp-regulation-RalBP1 was found to be overexpressed in tumor at stage I and IV.


Gene Details



NC_000018.9 (9475530..9538106)

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Gene Type protein coding
Gene Family -
Description RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]  
Chromosome 18
Location 18p11.22
Start 9475530  
End 9538106  
Strand +  
Gene Sequence

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Length 62577  
OMIM ID 605801   
HGNC ID HGNC:9841   
Unigene ID Hs.528993   
Ensembl ID ENSG00000017797   
PharmGKB ID PA34199   

mRNA Information


mRNA ID ?NM_006788.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS11845.1



Protein Information


      
Protein IDNP_006779.1
Protein NameralA binding protein 1
Molecular Wt. (Da)0
Protein Sequence

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Length 655  
Uniprot IDQ9H159
Ensembl Protein ID ENSP00000262150  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation297
SPhosphorylation92;-
SPhosphorylation93;-
TPhosphorylation27
SPhosphorylation29
SPhosphorylation34
SPhosphorylation30
SPhosphorylation463
YPhosphorylation270
TPhosphorylation280
SPhosphorylation11
TAcetylation2
SPhosphorylation645
SPhosphorylation48
SPhosphorylation62
SPhosphorylation116
SPhosphorylation461

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
891CCNB1454NP_114172.1in vitro;in vivo;yeast 2-hybrid12775724   
1173AP2M13014NP_004059.2in vitro;in vivo;yeast 2-hybrid10910768   
5879RAC13627NP_061485.1in vitro;yeast 2-hybrid7673236   
5898RALA1549NP_005393.2in vitro;yeast 2-hybrid7673236   
5899RALB1550NP_002872.1in vitro;yeast 2-hybrid7673236   
9185REPS22262Q8NFH8in vitro;yeast 2-hybrid9422736   
29911HOOK29698NP_037444.2yeast 2-hybrid16189514   
85021REPS19687NP_114128.3in vitro;in vivo;yeast 2-hybrid9395447   


Pathway Information


                  
Pathway Name Pathway ID
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Ras signaling pathway hsa04014


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04381190-371  RhoGap_RalBP1
cl02570190-371  RhoGAP superfamily
smart00324207-380  RhoGAP
pfam00620210-349  RhoGAP
cd00159210-350  RhoGAP
cd04398190-350  RhoGAP_fRGD1
cd04400189-369  RhoGAP_fBEM3
cd04386187-349  RhoGAP_nadrin
cd04385210-350  RhoGAP_ARAP
cd04373190-349  RhoGAP_p190
cd04384188-348  RhoGAP_CdGAP
cd04387208-350  RhoGAP_Bcr
cd04372208-350  RhoGAP_chimaerin
cd04403190-349  RhoGAP_ARHGAP27_15_12_9
cd04377190-350  RhoGAP_myosin_IX
cd04404190-368  RhoGAP-p50rhoGAP
cd04391189-348  RhoGAP_ARHGAP18
cd04393188-350  RhoGAP_FAM13A1a
cd04374214-349  RhoGAP_Graf
cd04395190-350  RhoGAP_ARHGAP21
cd04378190-349  RhoGAP_GMIP_PARG1
cd04382208-350  RhoGAP_MgcRacGAP
cd04406209-350  RhoGAP_myosin_IXA
cd04390189-350  RhoGAP_ARHGAP22_24_25
cd04407209-350  RhoGAP_myosin_IXB
cd04402189-350  RhoGAP_ARHGAP20
cd04408209-350  RhoGAP_GMIP
cd04375187-350  RhoGAP_DLC1
cd04409190-350  RhoGAP_PARG1
cd04383209-373  RhoGAP_srGAP
cd04376209-350  RhoGAP_ARHGAP6
cd04389190-348  RhoGAP_KIAA1688
cd04379190-348  RhoGAP_SYD1
cd04394189-348  RhoGAP-ARHGAP11A
cd04397190-354  RhoGAP_fLRG1
cd04392217-350  RhoGAP_ARHGAP19
cd04396189-350  RhoGAP_fSAC7_BAG7
cd04388210-348  RhoGAP_p85
cd04399250-329  RhoGAP_fRGD2
COG1196400-627  Smc
COG1196396-607  Smc
TIGR02168398-614  SMC_prok_B
TIGR02169400-621  SMC_prok_A
COG1196436-610  Smc
TIGR02168400-617  SMC_prok_B
COG1196393-621  Smc
COG1196398-610  Smc
TIGR02168400-634  SMC_prok_B
COG1196398-612  Smc
COG1196456-614  Smc
COG1196423-612  Smc
COG1196429-610  Smc
TIGR02168420-607  SMC_prok_B
TIGR02168457-609  SMC_prok_B
TIGR02168395-602  SMC_prok_B
TIGR02169399-607  SMC_prok_A
COG1196426-602  Smc
COG1196425-610  Smc
PTZ00121431-652  PTZ00121
COG0419395-610  SbcC
pfam12795431-605  MscS_porin
TIGR02168476-610  SMC_prok_B
pfam04111435-523  APG6
COG4942391-612  EnvC
PRK06241210-311  PRK06241
TIGR02169388-619  SMC_prok_A
COG1196454-610  Smc
COG1196398-610  Smc
PTZ00121440-652  PTZ00121
TIGR00618431-606  sbcc
TIGR02168444-610  SMC_prok_B
pfam02463399-619  SMC_N
COG0419393-610  SbcC


Ontology Information


   
HPRD ID6577
Molecular ClassGTPase activating protein
Molecular FunctionGTPase activator activity (GO:0005096)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q15311DB00398SorafenibSmallMoleculeDrug
Q15311DB00541VincristineSmallMoleculeDrug
Q15311DB00564CarbamazepineSmallMoleculeDrug
Q15311DB00997DoxorubicinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO