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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PRDX3 | 10935 | Peroxiredoxin 3 | 10 | AOP1; MER5; AOP-1; SP-22; HBC189; PRO1748; prx-III |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22799385 | 2012 | Cell line : - Source : Department of Gastrointestinal Surgery, Guangdong Provincial Peoples Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 13 Stage : - | 2-D Gel electrophoresis and MALDI-TOF mass spectrometry | Up-regulation | - | This Gene differentially expressed and analysed by 2-D Gel Electrophoresis. For proteomic analysis, fresh CRC specimens, which included both tumor tissue and adjacent normal tissue, were obtained from 13 patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 10 |
| Location | 10q25-q26 |
| Start | 119167699 |
| End | 119178865 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11167 |
| OMIM ID | 604769 |
| HGNC ID | HGNC:9354 |
| Unigene ID | Hs.523302 |
| Ensembl ID | ENSG00000165672 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001302272.1 |
|---|---|
| Exon | join(1..111,1713..1845,4274..4415,4994..5129,6381..6484, 10333..11167) | mRNA Sequence | Download Select all |
| Length | 1475 |
CDS Information
| Location | join(76..111,1713..1845,4274..4415,4994..5129,6381..6484, 9524..9689,10333..10386) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7611.1 |
Protein Information
| Protein ID | NP_001289201.1 |
|---|---|
| Protein Name | Peroxiredoxin 3 |
| Molecular Wt. (Da) | 15137 |
| Protein Sequence | Download Select all |
| Length | 198 |
| Uniprot ID | Q03468 |
| Ensembl Protein ID | ENSP00000348089 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 91 |
| K | Acetylation | 73 |
| C | S-Nitrosylation | 229 |
| C | S-Nitrosylation | 211 |
Enzyme Information
| EC | 1.11.1.15 |
|---|---|
| Name | peroxiredoxin thioredoxin peroxidase tryparedoxin peroxidase alkyl hydroperoxide reductase C22 AhpC TrxPx TXNPx Prx PRDX |
| Class | Oxidoreductases; Acting on a peroxide as acceptor; Peroxidases |
| Sysname | thiol-containing-reductant:hydroperoxide oxidoreductase |
| Substrate | R'-SH [CPD:C16736]; ROOH |
| Product | R'-S-S-R' [CPD:C15496]; H2O [CPD:C00001]; ROH |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 26750 | RPS6KC1 | 10204 | NP_036556.2 | in vitro;in vivo;yeast 2-hybrid | 15750338 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03015 | 65-236 | PRX_Typ2cys |
| cl00388 | 65-236 | Thioredoxin_like superfamily |
| cd02971 | 69-213 | PRX_family |
| pfam00578 | 65-197 | AhpC-TSA |
| cd03016 | 86-249 | PRX_1cys |
| cd03018 | 69-208 | PRX_AhpE_like |
| COG1225 | 85-220 | Bcp |
| cd03017 | 67-214 | PRX_BCP |
| cd03014 | 64-197 | PRX_Atyp2cys |
| pfam08534 | 76-208 | Redoxin |
| COG2077 | 61-202 | Tpx |
| PRK00522 | 63-197 | tpx |
| pfam10417 | 218-253 | 1-cysPrx_C |
| cl22976 | 218-253 | 1-cysPrx_C superfamily |
| PRK09437 | 79-198 | bcp |
| cd02966 | 81-197 | TlpA_like_family |
| pfam13905 | 92-195 | Thioredoxin_8 |
| cd03013 | 78-200 | PRX5_like |
| cd02970 | 78-195 | PRX_like2 |
| COG1999 | 68-195 | Sco1 |
| cd02968 | 85-135 | SCO |
| COG0678 | 63-200 | AHP1 |
| PTZ00253 | 59-255 | PTZ00253 |
| COG0450 | 65-253 | AhpC |
| TIGR03137 | 63-243 | AhpC |
| PTZ00137 | 54-253 | PTZ00137 |
| PRK15000 | 65-253 | PRK15000 |
| PRK10382 | 66-243 | PRK10382 |
| PRK13190 | 67-256 | PRK13190 |
| PRK13189 | 69-249 | PRK13189 |
| PRK13191 | 88-256 | PRK13191 |
| PRK13599 | 88-241 | PRK13599 |
Ontology Information
| HPRD ID | 1260 |
|---|---|
| Molecular Class | Enzyme: Peroxidase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.