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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21255561 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 64 Stage : - | Western blotting, Immunohistochemistry | Up-regulation | 1.9-fold | SEC61? autoantibody levels may provide an alternative detection indicator for CRC, particularly among early-stage patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008] |
| Chromosome | 9 |
| Location | 9q22.32-q3 |
| Start | 101984570 |
| End | 101992901 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8332 |
| OMIM ID | 609214 |
| HGNC ID | HGNC:16993 |
| Unigene ID | Hs.191887 |
| Ensembl ID | ENSG00000106803 |
| PharmGKB ID | PA134888963 |
Protein Information
| Protein ID | NP_006799.1 |
|---|---|
| Protein Name | Sec61 beta subunit |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 96 |
| Uniprot ID | Q9Y2X7 |
| Ensembl Protein ID | ENSP00000225394 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 17 |
| T | Phosphorylation | 5;- |
| T | Phosphorylation | 9;- |
| S | Phosphorylation | 13;- |
| S | Phosphorylation | 14;- |
| S | Phosphorylation | 19;- |
| S | Phosphorylation | 7 |
| S | Phosphorylation | 29 |
| T | Phosphorylation | 30 |
| S | Phosphorylation | 49 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 338 | APOB | 133 | NP_000375.2 | in vivo | 9565615 |
| 23471 | TRAM1 | 5545 | NP_055109.1 | in vivo | 9512475 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Phagosome | hsa04145 |
| Protein export | hsa03060 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| Vibrio cholerae infection | hsa05110 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03911 | 52-91 | Sec61_beta |
| cl23537 | 52-91 | Sec61_beta superfamily |
| PRK01253 | 54-89 | PRK01253 |
| cl09194 | 54-89 | SBH1 superfamily |
Ontology Information
| HPRD ID | 6039 |
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.