Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25123036 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 120 cancerous and 41 paired noncancerous colorectal specimens. Stage : - | real time RT-PCR | Up-regulation | - | KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma, with additional prognostic value in patients with highly invasive tumors and/or positive lymph nodes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kallikreins, "Serine peptidases / Serine peptidases" |
| Description | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed. |
| Chromosome | 19 |
| Location | 19q13.33 |
| Start | 51022231 |
| End | 51028034 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5804 |
| OMIM ID | 604434 |
| HGNC ID | HGNC:6359 |
| Unigene ID | Hs.57771 |
| Ensembl ID | ENSG00000167757 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_006853.2 |
|---|---|
| Exon | join(1..91,2369..2443,3241..3397,3725..3990,4807..4943, 5338..5804) | mRNA Sequence | Download Select all |
| Length | 1195 |
CDS Information
| Location | join(518..578,2369..2443,4807..4943,5338..5490) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001129504.1 |
|---|---|
| Protein Name | kallikrein-related peptidase 11 |
| Molecular Wt. (Da) | 25632 |
| Protein Sequence | Download Select all |
| Length | 250 |
| Uniprot ID | P18084 |
| Ensembl Protein ID | ENSP00000296181 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 54-278 | Tryp_SPc |
| cl21584 | 54-278 | Tryp_SPc superfamily |
| smart00020 | 53-275 | Tryp_SPc |
| pfam00089 | 54-275 | Trypsin |
| COG5640 | 48-280 | COG5640 |
Ontology Information
| HPRD ID | 2781 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.