Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHD3 | 1107 | chromodomain helicase DNA binding protein 3  | 17 | Mi-2a, ZFH, Mi2-ALPHA  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21447119    | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 29 gastric cancers with high MSI (MSI-H), 45 GCs with low MSI (MSI-L)/stable MSI (MSS), 35 colorectal cancers (CRCs) with MSI-H and 45 CRCs with MSI-L/MSS Stage : - | Immunohistochemistry,MSI-L/MSS by SSCP | Frameshift Mutation | - | Frameshift mutation and loss of expression of CHD genes are common in GCs and CRCs with MSI-H. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, PHD-type |
| Description | This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]   |
| Chromosome | 17 |
| Location | 17p13 |
| Start | 7788096   |
| End | 7816075   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 27980   |
| OMIM ID | 602120    |
| HGNC ID | HGNC:1918    |
| Unigene ID | Hs.25601    |
| Ensembl ID | ENSG00000170004    |
| PharmGKB ID | PA26454    |
mRNA Information
| mRNA ID | XM_011524037.1 |
|---|---|
| Exon | complement(390..508)   | mRNA Sequence |    Download   Select all |
| Length | 661   |
CDS Information
| Location | 286..615 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS32553.2 |    
Protein Information
| Protein ID | XP_011522339.1 |
|---|---|
| Protein Name | chromodomain helicase DNA binding protein 3 |
| Molecular Wt. (Da) | 11734 |
| Protein Sequence |    Download   Select all |
| Length | 109   |
| Uniprot ID | Q16288 |    
| Ensembl Protein ID | ENSP00000318328   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1660 |
| S | Phosphorylation | 772 |
| S | Phosphorylation | 1601 |
| S | Phosphorylation | 713 |
| S | Phosphorylation | 713 |
| S | Phosphorylation | 1601 |
| S | Phosphorylation | 1660;- |
| S | Phosphorylation | 1601;- |
| S | Phosphorylation | 1601;- |
| S | Phosphorylation | 383;- |
| S | Phosphorylation | 324;- |
| S | Phosphorylation | 324;- |
| Y | Phosphorylation | 143;- |
| S | Phosphorylation | 132;- |
| S | Phosphorylation | 73;- |
| Y | Phosphorylation | 84;- |
| S | Phosphorylation | 73;- |
| Y | Phosphorylation | 84;- |
| S | Phosphorylation | 138;- |
| S | Phosphorylation | 79;- |
| S | Phosphorylation | 79;- |
| S | Phosphorylation | 1664;- |
| S | Phosphorylation | 1605;- |
| S | Phosphorylation | 1605;- |
| S | Phosphorylation | 66;- |
| T | Phosphorylation | 774 |
| T | Phosphorylation | 715 |
| T | Phosphorylation | 715 |
| S | Phosphorylation | 1420 |
| S | Phosphorylation | 1423 |
| S | Phosphorylation | 1426 |
| S | Phosphorylation | 1361 |
| S | Phosphorylation | 1364 |
| S | Phosphorylation | 1367 |
| S | Phosphorylation | 1361 |
| S | Phosphorylation | 1364 |
| S | Phosphorylation | 1367 |
| S | Phosphorylation | 1608 |
| S | Phosphorylation | 1549 |
| S | Phosphorylation | 1549 |
| S | Phosphorylation | 656 |
| S | Phosphorylation | 597 |
| S | Phosphorylation | 597 |
| T | Phosphorylation | 1628 |
| T | Phosphorylation | 1569 |
| T | Phosphorylation | 1569 |
| S | Phosphorylation | 771 |
| S | Phosphorylation | 712 |
| S | Phosphorylation | 712 |
| T | Phosphorylation | 919 |
| S | Phosphorylation | 920 |
| T | Phosphorylation | 925 |
| S | Phosphorylation | 933 |
| T | Phosphorylation | 860 |
| S | Phosphorylation | 861 |
| T | Phosphorylation | 866 |
| S | Phosphorylation | 874 |
| T | Phosphorylation | 860 |
| S | Phosphorylation | 861 |
| T | Phosphorylation | 866 |
| S | Phosphorylation | 874 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1363 |    CPE |    272 |    NP_001864.1 |    yeast 2-hybrid |    16169070    |
| 2017 |    CTTN |    1268 |    NP_005222.2 |    yeast 2-hybrid |    16169070    |
| 2874 |    GPS2 |    11878 |    NP_004480.1 |    yeast 2-hybrid |    16169070    |
| 3064 |    HTT |    883 |    NP_002102.4 |    in vitro;yeast 2-hybrid |    15383276    |
| 3837 |    KPNB1 |    4114 |    NP_002256.2 |    yeast 2-hybrid |    15383276    |
| 3838 |    KPNA2 |    2818 |    NP_002257.1 |    yeast 2-hybrid |    15383276    |
| 4747 |    NEFL |    1206 |    NP_006149.2 |    yeast 2-hybrid |    15383276    |
| 5110 |    PCMT1 |    8908 |    NP_005380.2 |    yeast 2-hybrid |    16169070    |
| 5553 |    PRG2 |    9283 |    NP_002719.3 |    yeast 2-hybrid |    16169070    |
| 5764 |    PTN |    1199 |    NP_002816.1 |    yeast 2-hybrid |    15383276    |
| 5802 |    PTPRS |    3344 |    NP_002841.3 |    yeast 2-hybrid |    16169070    |
| 6303 |    SAT1 |    2431 |    NP_002961.1 |    yeast 2-hybrid |    16169070    |
| 6304 |    SATB1 |    3647 |    NP_002962.1 |    in vivo |    12374985    |
| 6886 |    TAL1 |    1753 |    NP_003180.1 |    yeast 2-hybrid |    15383276    |
| 7105 |    TSPAN6 |    2179 |    NP_003261.1 |    yeast 2-hybrid |    16169070    |
| 7157 |    TP53 |    1859 |    NP_000537.3 |    yeast 2-hybrid |    1   096   199   115   383   270    |
| 7161 |    TP73 |    3587 |    NP_005418.1 |    yeast 2-hybrid |    10961991    |
| 7329 |    UBE2I |    9045 |    NP_003336.1 |    yeast 2-hybrid |    14609633    |
| 7341 |    SUMO1 |    3554 |    NP_003343.1 |    yeast 2-hybrid |    14609633    |
| 7431 |    VIM |    1899 |    NP_003371.2 |    yeast 2-hybrid |    15383276    |
| 7518 |    XRCC4 |    15951 |    NP_071801.1 |    yeast 2-hybrid |    16169070    |
| 8553 |    BHLHE40 |    16050 |    NP_003661.1 |    yeast 2-hybrid |    16169070    |
| 8764 |    TNFRSF14 |    4122 |    NP_003811.2 |    yeast 2-hybrid |    16169070    |
| 8789 |    FBP2 |    4322 |    NP_003828.2 |    yeast 2-hybrid |    16169070    |
| 8880 |    FUBP1 |    10349 |    AAH17247.1 |    yeast 2-hybrid |    16169070    |
| 9039 |    UBA3 |    4413 |    NP_003959.3 |    yeast 2-hybrid |    16169070    |
| 9905 |    SGSM2 |    15284 |    NP_055668.2 |    yeast 2-hybrid |    16169070    |
| 10120 |    ACTR1B |    5508 |    NP_005726.1 |    yeast 2-hybrid |    16169070    |
| 10169 |    SERF2 |    5447 |    NP_005761.2 |    yeast 2-hybrid |    16169070    |
| 10190 |    TXNDC9 |    15592 |    NP_005774.2 |    yeast 2-hybrid |    16169070    |
| 10320 |    IKZF1 |    4318 |    NP_006051.1 |    in vivo;yeast 2-hybrid |    10204490    |
| 10625 |    IVNS1ABP |    10004 |    NP_006460.2 |    yeast 2-hybrid |    16169070    |
| 10807 |    SDCCAG3 |    15307 |    NP_001034796.1 |    yeast 2-hybrid |    16169070    |
| 10808 |    HSPH1 |    9990 |    NP_006635.2 |    yeast 2-hybrid |    16169070    |
| 10989 |    IMMT |    2658 |    NP_006830.2 |    yeast 2-hybrid |    15383276    |
| 22806 |    IKZF3 |    5869 |    NP_036613.2 |    in vivo |    10204490    |
| 22827 |    PUF60 |    18051 |    NP_510965.1 |    yeast 2-hybrid |    16169070    |
| 28964 |    GIT1 |    6577 |    NP_001078923.1 |    in vitro;yeast 2-hybrid |    15383276    |
| 28965 |    SLC27A6 |    9173 |    NP_054750.1 |    yeast 2-hybrid |    16169070    |
| 51548 |    SIRT6 |    12093 |    NP_057623.1 |    yeast 2-hybrid |    16169070    |
| 51588 |    PIAS4 |    6910 |    NP_056981.2 |    yeast 2-hybrid |    15383276    |
| 51593 |    SRRT |    10665 |    NP_056992.4 |    yeast 2-hybrid |    16169070    |
| 51631 |    LUC7L2 |    17456 |    NP_057103.2 |    yeast 2-hybrid |    16169070    |
| 54544 |    CRCT1 |    16635 |    NP_061933.1 |    yeast 2-hybrid |    16169070    |
| 55183 |    RIF1 |    10603 |    NP_060621.3 |    yeast 2-hybrid |    15383276    |
| 56992 |    KIF15 |    10037 |    NP_064627.1 |    yeast 2-hybrid |    16169070    |
| 57002 |    C7orf36 |    16669 |    NP_064577.1 |    yeast 2-hybrid |    16169070    |
| 79137 |    FAM134A |    12807 |    NP_077269.3 |    yeast 2-hybrid |    16169070    |
| 80145 |    THOC7 |    17632 |    NP_079351.2 |    yeast 2-hybrid |    16169070    |
| 84103 |    C4orf17 |    12825 |    NP_115525.1 |    yeast 2-hybrid |    16169070    |
| 93974 |    ATPIF1 |    16529 |    NP_057395.1 |    yeast 2-hybrid |    16169070    |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00079 | 1057-1182  | HELICc |
| cl21455 | 1057-1182  | P-loop_NTPase superfamily |
| cd15531 | 381-423  | PHD1_CHD_II |
| cl22851 | 381-423  | PHD_SF superfamily |
| cd15532 | 458-500  | PHD2_CHD_II |
| cl22851 | 458-500  | PHD_SF superfamily |
| cd00046 | 756-914  | DEXDc |
| cl21455 | 756-914  | P-loop_NTPase superfamily |
| cd00024 | 628-683  | CHROMO |
| cl17459 | 628-683  | CHROMO superfamily |
| cd00024 | 540-584  | CHROMO |
| cl17459 | 540-584  | CHROMO superfamily |
| pfam08074 | 1735-1907  | CHDCT2 |
| cl06903 | 1735-1907  | CHDCT2 superfamily |
| pfam06461 | 1380-1517  | DUF1086 |
| cl05788 | 1380-1517  | DUF1086 superfamily |
| pfam08073 | 147-201  | CHDNT |
| cl06902 | 147-201  | CHDNT superfamily |
| smart00490 | 1090-1174  | HELICc |
| pfam00271 | 1094-1174  | Helicase_C |
| cd15533 | 458-500  | PHD1_PHF12 |
| pfam06465 | 1312-1357  | DUF1087 |
| cl05792 | 1312-1357  | DUF1087 superfamily |
| cd15532 | 381-423  | PHD2_CHD_II |
| cd15539 | 381-423  | PHD1_AIRE |
| cd15523 | 458-500  | PHD_PHF21A |
| cd15523 | 381-423  | PHD_PHF21A |
| cd15539 | 458-500  | PHD1_AIRE |
| pfam00628 | 458-502  | PHD |
| cd15515 | 459-500  | PHD1_KDM5A_like |
| cd15541 | 458-500  | PHD_TIF1_like |
| pfam00628 | 381-423  | PHD |
| cd15519 | 382-423  | PHD1_Lid2p_like |
| cd15559 | 458-500  | PHD1_BPTF |
| cd15524 | 381-423  | PHD_PHF21B |
| cd15519 | 457-500  | PHD1_Lid2p_like |
| cd15533 | 381-423  | PHD1_PHF12 |
| cd15535 | 381-423  | PHD1_Rco1 |
| smart00249 | 458-500  | PHD |
| cd15604 | 459-500  | PHD1_KDM5C_5D |
| cd15531 | 458-500  | PHD1_CHD_II |
| cd15605 | 459-500  | PHD1_Lid_like |
| cd15535 | 458-500  | PHD1_Rco1 |
| smart00249 | 381-423  | PHD |
| cd15524 | 458-500  | PHD_PHF21B |
| cd15541 | 381-423  | PHD_TIF1_like |
| cd15567 | 381-423  | PHD4_NSD |
| cd15543 | 458-500  | PHD_RSF1 |
| cd15567 | 458-500  | PHD4_NSD |
| cd15627 | 459-500  | PHD_BAZ1A |
| cd15568 | 381-422  | PHD5_NSD |
| cd15537 | 381-423  | PHD_BS69 |
| cd15489 | 381-423  | PHD_SF |
| cd15545 | 458-500  | PHD_BAZ2A_like |
| cd15559 | 381-423  | PHD1_BPTF |
| cd15602 | 459-500  | PHD1_KDM5A |
| cd15628 | 459-500  | PHD_BAZ1B |
| cd15603 | 459-500  | PHD1_KDM5B |
| cd15527 | 459-500  | PHD2_KAT6A_6B |
| cd15622 | 458-500  | PHD_TIF1alpha |
| cd15527 | 382-423  | PHD2_KAT6A_6B |
| smart00298 | 633-685  | CHROMO |
| cd15538 | 381-423  | PHD_PRKCBP1 |
| cd15625 | 457-500  | PHD_TIF1delta |
| cd15661 | 381-421  | PHD5_NSD3 |
| cd15617 | 459-500  | PHD_UHRF2 |
| cd15525 | 459-500  | PHD_UHRF1_2 |
| cd15543 | 381-423  | PHD_RSF1 |
| cd15627 | 382-423  | PHD_BAZ1A |
| cd15628 | 382-423  | PHD_BAZ1B |
| cd15622 | 381-423  | PHD_TIF1alpha |
| cd15544 | 382-423  | PHD_BAZ1A_like |
| cd15545 | 381-423  | PHD_BAZ2A_like |
| cd15544 | 459-500  | PHD_BAZ1A_like |
| cd15625 | 378-423  | PHD_TIF1delta |
| cd15624 | 458-500  | PHD_TIF1gamma |
| pfam00385 | 633-676  | Chromo |
| cd15489 | 458-500  | PHD_SF |
| cd15536 | 458-500  | PHD_PHRF1 |
| cd15568 | 458-499  | PHD5_NSD |
| cd15513 | 459-500  | PHD5_KMT2C_like |
| cd15624 | 381-423  | PHD_TIF1gamma |
| cd15658 | 458-500  | PHD4_NSD3 |
| cd15656 | 458-500  | PHD4_NSD1 |
| cd15513 | 382-423  | PHD5_KMT2C_like |
| cd15616 | 459-500  | PHD_UHRF1 |
| cd15536 | 381-423  | PHD_PHRF1 |
| cd15660 | 381-421  | PHD5_NSD2 |
| cd15629 | 382-423  | PHD_BAZ2A |
| cd11725 | 372-429  | ADDz_Dnmt3 |
| cd15594 | 382-423  | PHD2_KMT2C |
| cd15499 | 382-425  | PHD1_MTF2_PHF19_like |
| cd15604 | 382-423  | PHD1_KDM5C_5D |
| cd15525 | 382-423  | PHD_UHRF1_2 |
| cd15657 | 458-500  | PHD4_NSD2 |
| cd15629 | 459-500  | PHD_BAZ2A |
| cd15595 | 459-500  | PHD2_KMT2D |
| cd15515 | 382-423  | PHD1_KDM5A_like |
| cd15538 | 458-500  | PHD_PRKCBP1 |
| cd15623 | 459-500  | PHD_TIF1beta |
| cd15504 | 381-423  | PHD_PRHA_like |
| cd15595 | 382-423  | PHD2_KMT2D |
| cd15497 | 381-423  | PHD1_Snt2p_like |
| cd15617 | 382-423  | PHD_UHRF2 |
| cd15658 | 381-423  | PHD4_NSD3 |
| cd15623 | 382-423  | PHD_TIF1beta |
| cd15497 | 458-500  | PHD1_Snt2p_like |
| cd15626 | 382-423  | PHD_SP110_140 |
| cd15605 | 382-423  | PHD1_Lid_like |
| cd15603 | 382-423  | PHD1_KDM5B |
| cd15656 | 381-423  | PHD4_NSD1 |
| cd15510 | 459-500  | PHD2_KMT2C_like |
| cd15602 | 382-426  | PHD1_KDM5A |
| cd15530 | 381-423  | PHD2_d4 |
| cd15630 | 458-500  | PHD_BAZ2B |
| smart00298 | 509-585  | CHROMO |
| cd15562 | 382-423  | PHD2_PHF14 |
| cd15661 | 458-498  | PHD5_NSD3 |
| cd15510 | 382-423  | PHD2_KMT2C_like |
| cd15563 | 382-423  | PHD3_PHF14 |
| cd15626 | 459-500  | PHD_SP110_140 |
| cd15537 | 458-500  | PHD_BS69 |
| cd15594 | 459-500  | PHD2_KMT2C |
| cd15630 | 381-423  | PHD_BAZ2B |
| cd15616 | 382-423  | PHD_UHRF1 |
| cd15502 | 382-423  | PHD_Phf1p_Phf2p_like |
| cd15529 | 459-500  | PHD2_PHF10 |
| cd11726 | 372-425  | ADDz_ATRX |
| cd15530 | 458-500  | PHD2_d4 |
| cd15657 | 381-423  | PHD4_NSD2 |
| cd15504 | 458-500  | PHD_PRHA_like |
| cd15534 | 459-499  | PHD2_PHF12_Rco1 |
| cd15509 | 382-423  | PHD1_KMT2C_like |
| cd15578 | 382-424  | PHD1_MTF2 |
| cd15529 | 382-423  | PHD2_PHF10 |
| cd15502 | 459-500  | PHD_Phf1p_Phf2p_like |
| cd15660 | 458-498  | PHD5_NSD2 |
| cd15648 | 382-423  | PHD1_NSD1_2 |
| cd15659 | 382-421  | PHD5_NSD1 |
| cd15534 | 382-421  | PHD2_PHF12_Rco1 |
| cd15505 | 381-423  | PHD_ING |
| cd15562 | 459-500  | PHD2_PHF14 |
| cd15499 | 459-502  | PHD1_MTF2_PHF19_like |
| cd15506 | 459-500  | PHD1_KMT2A_like |
| cd11726 | 453-478  | ADDz_ATRX |
| cd15578 | 459-500  | PHD1_MTF2 |
| cd15585 | 381-423  | PHD_ING3 |
| cd15501 | 459-500  | PHD_Int12 |
| cd04718 | 401-426  | BAH_plant_2 |
| cl02608 | 401-426  | BAH superfamily |
| cd15590 | 458-500  | PHD2_KMT2A |
| cd15566 | 458-499  | PHD3_NSD |
| cd15572 | 459-500  | PHD_BRPF |
| cd15566 | 381-422  | PHD3_NSD |
| cd15648 | 459-501  | PHD1_NSD1_2 |
| cd15507 | 458-500  | PHD2_KMT2A_like |
| cd15563 | 459-500  | PHD3_PHF14 |
| cd15522 | 381-423  | PHD_TAF3 |
| cd15591 | 458-500  | PHD2_KMT2B |
| cd15676 | 454-500  | PHD_BRPF1 |
| cd15659 | 459-498  | PHD5_NSD1 |
| cd04718 | 478-501  | BAH_plant_2 |
| cl02608 | 478-501  | BAH superfamily |
| cd15685 | 381-426  | PHD_ING5 |
| cd11672 | 372-423  | ADDz |
| cd15522 | 458-500  | PHD_TAF3 |
| cd15677 | 459-500  | PHD_BRPF2 |
| cd15509 | 459-500  | PHD1_KMT2C_like |
| cd15585 | 458-500  | PHD_ING3 |
| cd15584 | 381-423  | PHD_ING1_2 |
| cd15492 | 459-500  | PHD_BRPF_JADE_like |
| cd15677 | 385-423  | PHD_BRPF2 |
| cd15586 | 381-423  | PHD_ING4_5 |
| cd15564 | 381-424  | PHD1_NSD |
| cd15492 | 382-423  | PHD_BRPF_JADE_like |
| cd15678 | 458-500  | PHD_BRPF3 |
| cd15507 | 381-423  | PHD2_KMT2A_like |
| cd15682 | 381-426  | PHD_ING1 |
| cd15540 | 459-485  | PHD2_AIRE |
| cd15679 | 382-423  | PHD_JADE1 |
| cd15573 | 382-423  | PHD_JADE |
| cd11672 | 453-500  | ADDz |
| cd15564 | 458-501  | PHD1_NSD |
| cd15680 | 459-500  | PHD_JADE2 |
| cd11728 | 372-423  | ADDz_Dnmt3b |
| pfam00176 | 739-1035  | SNF2_N |
| PLN03142 | 719-1273  | PLN03142 |
| COG0553 | 733-1232  | HepA |
| smart00487 | 728-938  | DEXDc |
| PRK04914 | 877-983  | PRK04914 |
| COG1111 | 879-1258  | MPH1 |
| COG5034 | 373-426  | TNG2 |
| pfam11496 | 1029-1192  | HDA2-3 |
| COG0513 | 1057-1174  | SrmB |
| PHA03247 | 1512-1680  | PHA03247 |
| PHA03418 | 1519-1668  | PHA03418 |
| PHA03169 | 1509-1694  | PHA03169 |
| PHA03169 | 1537-1746  | PHA03169 |
| COG5141 | 462-533  | COG5141 |
Ontology Information
| HPRD ID | 1868 |    
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
