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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CHD3 1107 chromodomain helicase DNA binding protein 3  17Mi-2a, ZFH, Mi2-ALPHA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21447119   2011Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 29 gastric cancers with high MSI (MSI-H), 45 GCs with low MSI (MSI-L)/stable MSI (MSS), 35 colorectal cancers (CRCs) with MSI-H and 45 CRCs with MSI-L/MSS

Stage : -

Immunohistochemistry,MSI-L/MSS by SSCP Frameshift Mutation-Frameshift mutation and loss of expression of CHD genes are common in GCs and CRCs with MSI-H.


Gene Details



NC_000017.10 (7788096..7816075)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17p13
Start 7788096  
End 7816075  
Strand +  
Gene Sequence

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Length 27980  
OMIM ID 602120   
HGNC ID HGNC:1918   
Unigene ID Hs.25601   
Ensembl ID ENSG00000170004   
PharmGKB ID PA26454   

mRNA Information


mRNA ID XM_011524037.1
Exon complement(390..508)  
mRNA Sequence

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Length 661  



CDS Information


   
Location286..615
CDS Sequence

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CCDS ID CCDS32553.2



Protein Information


      
Protein IDXP_011522339.1
Protein Namechromodomain helicase DNA binding protein 3
Molecular Wt. (Da)11734
Protein Sequence

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Length 109  
Uniprot IDQ16288
Ensembl Protein ID ENSP00000318328  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1660
SPhosphorylation772
SPhosphorylation1601
SPhosphorylation713
SPhosphorylation713
SPhosphorylation1601
SPhosphorylation1660;-
SPhosphorylation1601;-
SPhosphorylation1601;-
SPhosphorylation383;-
SPhosphorylation324;-
SPhosphorylation324;-
YPhosphorylation143;-
SPhosphorylation132;-
SPhosphorylation73;-
YPhosphorylation84;-
SPhosphorylation73;-
YPhosphorylation84;-
SPhosphorylation138;-
SPhosphorylation79;-
SPhosphorylation79;-
SPhosphorylation1664;-
SPhosphorylation1605;-
SPhosphorylation1605;-
SPhosphorylation66;-
TPhosphorylation774
TPhosphorylation715
TPhosphorylation715
SPhosphorylation1420
SPhosphorylation1423
SPhosphorylation1426
SPhosphorylation1361
SPhosphorylation1364
SPhosphorylation1367
SPhosphorylation1361
SPhosphorylation1364
SPhosphorylation1367
SPhosphorylation1608
SPhosphorylation1549
SPhosphorylation1549
SPhosphorylation656
SPhosphorylation597
SPhosphorylation597
TPhosphorylation1628
TPhosphorylation1569
TPhosphorylation1569
SPhosphorylation771
SPhosphorylation712
SPhosphorylation712
TPhosphorylation919
SPhosphorylation920
TPhosphorylation925
SPhosphorylation933
TPhosphorylation860
SPhosphorylation861
TPhosphorylation866
SPhosphorylation874
TPhosphorylation860
SPhosphorylation861
TPhosphorylation866
SPhosphorylation874

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1363CPE272NP_001864.1yeast 2-hybrid16169070   
2017CTTN1268NP_005222.2yeast 2-hybrid16169070   
2874GPS211878NP_004480.1yeast 2-hybrid16169070   
3064HTT883NP_002102.4in vitro;yeast 2-hybrid15383276   
3837KPNB14114NP_002256.2yeast 2-hybrid15383276   
3838KPNA22818NP_002257.1yeast 2-hybrid15383276   
4747NEFL1206NP_006149.2yeast 2-hybrid15383276   
5110PCMT18908NP_005380.2yeast 2-hybrid16169070   
5553PRG29283NP_002719.3yeast 2-hybrid16169070   
5764PTN1199NP_002816.1yeast 2-hybrid15383276   
5802PTPRS3344NP_002841.3yeast 2-hybrid16169070   
6303SAT12431NP_002961.1yeast 2-hybrid16169070   
6304SATB13647NP_002962.1in vivo12374985   
6886TAL11753NP_003180.1yeast 2-hybrid15383276   
7105TSPAN62179NP_003261.1yeast 2-hybrid16169070   
7157TP531859NP_000537.3yeast 2-hybrid1   096   199   115   383   270   
7161TP733587NP_005418.1yeast 2-hybrid10961991   
7329UBE2I9045NP_003336.1yeast 2-hybrid14609633   
7341SUMO13554NP_003343.1yeast 2-hybrid14609633   
7431VIM1899NP_003371.2yeast 2-hybrid15383276   
7518XRCC415951NP_071801.1yeast 2-hybrid16169070   
8553BHLHE4016050NP_003661.1yeast 2-hybrid16169070   
8764TNFRSF144122NP_003811.2yeast 2-hybrid16169070   
8789FBP24322NP_003828.2yeast 2-hybrid16169070   
8880FUBP110349AAH17247.1yeast 2-hybrid16169070   
9039UBA34413NP_003959.3yeast 2-hybrid16169070   
9905SGSM215284NP_055668.2yeast 2-hybrid16169070   
10120ACTR1B5508NP_005726.1yeast 2-hybrid16169070   
10169SERF25447NP_005761.2yeast 2-hybrid16169070   
10190TXNDC915592NP_005774.2yeast 2-hybrid16169070   
10320IKZF14318NP_006051.1in vivo;yeast 2-hybrid10204490   
10625IVNS1ABP10004NP_006460.2yeast 2-hybrid16169070   
10807SDCCAG315307NP_001034796.1yeast 2-hybrid16169070   
10808HSPH19990NP_006635.2yeast 2-hybrid16169070   
10989IMMT2658NP_006830.2yeast 2-hybrid15383276   
22806IKZF35869NP_036613.2in vivo10204490   
22827PUF6018051NP_510965.1yeast 2-hybrid16169070   
28964GIT16577NP_001078923.1in vitro;yeast 2-hybrid15383276   
28965SLC27A69173NP_054750.1yeast 2-hybrid16169070   
51548SIRT612093NP_057623.1yeast 2-hybrid16169070   
51588PIAS46910NP_056981.2yeast 2-hybrid15383276   
51593SRRT10665NP_056992.4yeast 2-hybrid16169070   
51631LUC7L217456NP_057103.2yeast 2-hybrid16169070   
54544CRCT116635NP_061933.1yeast 2-hybrid16169070   
55183RIF110603NP_060621.3yeast 2-hybrid15383276   
56992KIF1510037NP_064627.1yeast 2-hybrid16169070   
57002C7orf3616669NP_064577.1yeast 2-hybrid16169070   
79137FAM134A12807NP_077269.3yeast 2-hybrid16169070   
80145THOC717632NP_079351.2yeast 2-hybrid16169070   
84103C4orf1712825NP_115525.1yeast 2-hybrid16169070   
93974ATPIF116529NP_057395.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd000791057-1182  HELICc
cl214551057-1182  P-loop_NTPase superfamily
cd15531381-423  PHD1_CHD_II
cl22851381-423  PHD_SF superfamily
cd15532458-500  PHD2_CHD_II
cl22851458-500  PHD_SF superfamily
cd00046756-914  DEXDc
cl21455756-914  P-loop_NTPase superfamily
cd00024628-683  CHROMO
cl17459628-683  CHROMO superfamily
cd00024540-584  CHROMO
cl17459540-584  CHROMO superfamily
pfam080741735-1907  CHDCT2
cl069031735-1907  CHDCT2 superfamily
pfam064611380-1517  DUF1086
cl057881380-1517  DUF1086 superfamily
pfam08073147-201  CHDNT
cl06902147-201  CHDNT superfamily
smart004901090-1174  HELICc
pfam002711094-1174  Helicase_C
cd15533458-500  PHD1_PHF12
pfam064651312-1357  DUF1087
cl057921312-1357  DUF1087 superfamily
cd15532381-423  PHD2_CHD_II
cd15539381-423  PHD1_AIRE
cd15523458-500  PHD_PHF21A
cd15523381-423  PHD_PHF21A
cd15539458-500  PHD1_AIRE
pfam00628458-502  PHD
cd15515459-500  PHD1_KDM5A_like
cd15541458-500  PHD_TIF1_like
pfam00628381-423  PHD
cd15519382-423  PHD1_Lid2p_like
cd15559458-500  PHD1_BPTF
cd15524381-423  PHD_PHF21B
cd15519457-500  PHD1_Lid2p_like
cd15533381-423  PHD1_PHF12
cd15535381-423  PHD1_Rco1
smart00249458-500  PHD
cd15604459-500  PHD1_KDM5C_5D
cd15531458-500  PHD1_CHD_II
cd15605459-500  PHD1_Lid_like
cd15535458-500  PHD1_Rco1
smart00249381-423  PHD
cd15524458-500  PHD_PHF21B
cd15541381-423  PHD_TIF1_like
cd15567381-423  PHD4_NSD
cd15543458-500  PHD_RSF1
cd15567458-500  PHD4_NSD
cd15627459-500  PHD_BAZ1A
cd15568381-422  PHD5_NSD
cd15537381-423  PHD_BS69
cd15489381-423  PHD_SF
cd15545458-500  PHD_BAZ2A_like
cd15559381-423  PHD1_BPTF
cd15602459-500  PHD1_KDM5A
cd15628459-500  PHD_BAZ1B
cd15603459-500  PHD1_KDM5B
cd15527459-500  PHD2_KAT6A_6B
cd15622458-500  PHD_TIF1alpha
cd15527382-423  PHD2_KAT6A_6B
smart00298633-685  CHROMO
cd15538381-423  PHD_PRKCBP1
cd15625457-500  PHD_TIF1delta
cd15661381-421  PHD5_NSD3
cd15617459-500  PHD_UHRF2
cd15525459-500  PHD_UHRF1_2
cd15543381-423  PHD_RSF1
cd15627382-423  PHD_BAZ1A
cd15628382-423  PHD_BAZ1B
cd15622381-423  PHD_TIF1alpha
cd15544382-423  PHD_BAZ1A_like
cd15545381-423  PHD_BAZ2A_like
cd15544459-500  PHD_BAZ1A_like
cd15625378-423  PHD_TIF1delta
cd15624458-500  PHD_TIF1gamma
pfam00385633-676  Chromo
cd15489458-500  PHD_SF
cd15536458-500  PHD_PHRF1
cd15568458-499  PHD5_NSD
cd15513459-500  PHD5_KMT2C_like
cd15624381-423  PHD_TIF1gamma
cd15658458-500  PHD4_NSD3
cd15656458-500  PHD4_NSD1
cd15513382-423  PHD5_KMT2C_like
cd15616459-500  PHD_UHRF1
cd15536381-423  PHD_PHRF1
cd15660381-421  PHD5_NSD2
cd15629382-423  PHD_BAZ2A
cd11725372-429  ADDz_Dnmt3
cd15594382-423  PHD2_KMT2C
cd15499382-425  PHD1_MTF2_PHF19_like
cd15604382-423  PHD1_KDM5C_5D
cd15525382-423  PHD_UHRF1_2
cd15657458-500  PHD4_NSD2
cd15629459-500  PHD_BAZ2A
cd15595459-500  PHD2_KMT2D
cd15515382-423  PHD1_KDM5A_like
cd15538458-500  PHD_PRKCBP1
cd15623459-500  PHD_TIF1beta
cd15504381-423  PHD_PRHA_like
cd15595382-423  PHD2_KMT2D
cd15497381-423  PHD1_Snt2p_like
cd15617382-423  PHD_UHRF2
cd15658381-423  PHD4_NSD3
cd15623382-423  PHD_TIF1beta
cd15497458-500  PHD1_Snt2p_like
cd15626382-423  PHD_SP110_140
cd15605382-423  PHD1_Lid_like
cd15603382-423  PHD1_KDM5B
cd15656381-423  PHD4_NSD1
cd15510459-500  PHD2_KMT2C_like
cd15602382-426  PHD1_KDM5A
cd15530381-423  PHD2_d4
cd15630458-500  PHD_BAZ2B
smart00298509-585  CHROMO
cd15562382-423  PHD2_PHF14
cd15661458-498  PHD5_NSD3
cd15510382-423  PHD2_KMT2C_like
cd15563382-423  PHD3_PHF14
cd15626459-500  PHD_SP110_140
cd15537458-500  PHD_BS69
cd15594459-500  PHD2_KMT2C
cd15630381-423  PHD_BAZ2B
cd15616382-423  PHD_UHRF1
cd15502382-423  PHD_Phf1p_Phf2p_like
cd15529459-500  PHD2_PHF10
cd11726372-425  ADDz_ATRX
cd15530458-500  PHD2_d4
cd15657381-423  PHD4_NSD2
cd15504458-500  PHD_PRHA_like
cd15534459-499  PHD2_PHF12_Rco1
cd15509382-423  PHD1_KMT2C_like
cd15578382-424  PHD1_MTF2
cd15529382-423  PHD2_PHF10
cd15502459-500  PHD_Phf1p_Phf2p_like
cd15660458-498  PHD5_NSD2
cd15648382-423  PHD1_NSD1_2
cd15659382-421  PHD5_NSD1
cd15534382-421  PHD2_PHF12_Rco1
cd15505381-423  PHD_ING
cd15562459-500  PHD2_PHF14
cd15499459-502  PHD1_MTF2_PHF19_like
cd15506459-500  PHD1_KMT2A_like
cd11726453-478  ADDz_ATRX
cd15578459-500  PHD1_MTF2
cd15585381-423  PHD_ING3
cd15501459-500  PHD_Int12
cd04718401-426  BAH_plant_2
cl02608401-426  BAH superfamily
cd15590458-500  PHD2_KMT2A
cd15566458-499  PHD3_NSD
cd15572459-500  PHD_BRPF
cd15566381-422  PHD3_NSD
cd15648459-501  PHD1_NSD1_2
cd15507458-500  PHD2_KMT2A_like
cd15563459-500  PHD3_PHF14
cd15522381-423  PHD_TAF3
cd15591458-500  PHD2_KMT2B
cd15676454-500  PHD_BRPF1
cd15659459-498  PHD5_NSD1
cd04718478-501  BAH_plant_2
cl02608478-501  BAH superfamily
cd15685381-426  PHD_ING5
cd11672372-423  ADDz
cd15522458-500  PHD_TAF3
cd15677459-500  PHD_BRPF2
cd15509459-500  PHD1_KMT2C_like
cd15585458-500  PHD_ING3
cd15584381-423  PHD_ING1_2
cd15492459-500  PHD_BRPF_JADE_like
cd15677385-423  PHD_BRPF2
cd15586381-423  PHD_ING4_5
cd15564381-424  PHD1_NSD
cd15492382-423  PHD_BRPF_JADE_like
cd15678458-500  PHD_BRPF3
cd15507381-423  PHD2_KMT2A_like
cd15682381-426  PHD_ING1
cd15540459-485  PHD2_AIRE
cd15679382-423  PHD_JADE1
cd15573382-423  PHD_JADE
cd11672453-500  ADDz
cd15564458-501  PHD1_NSD
cd15680459-500  PHD_JADE2
cd11728372-423  ADDz_Dnmt3b
pfam00176739-1035  SNF2_N
PLN03142719-1273  PLN03142
COG0553733-1232  HepA
smart00487728-938  DEXDc
PRK04914877-983  PRK04914
COG1111879-1258  MPH1
COG5034373-426  TNG2
pfam114961029-1192  HDA2-3
COG05131057-1174  SrmB
PHA032471512-1680  PHA03247
PHA034181519-1668  PHA03418
PHA031691509-1694  PHA03169
PHA031691537-1746  PHA03169
COG5141462-533  COG5141


Ontology Information


   
HPRD ID1868
Molecular ClassDNA binding protein
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessTransmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO