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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TOPBP1 11073 topoisomerase (DNA) II binding protein 1  3KIAA0259, TOP2BP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21388066   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 30 GC with high MSI (MSI-H), 15 GC with low MSI, 45 GC with microsatellite stable, 33 CRC samples with MSI-H, 15 CRC samples with MSI-L, and 45 CRC samples that were MSS were used.

Stage : -

SSCP and DNA sequencingFrameshift Mutation-Mutations might contribute to the development of GC and CRC with MSI by deregulation of the cell cycle and DNA damage signaling/repair.


Gene Details



NC_000003.11 (133319449..133380762, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3q22.1
Start 133319449  
End 133380762  
Strand -  
Gene Sequence

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Length 61314  
OMIM ID 607760   
HGNC ID HGNC:17008   
Unigene ID Hs.593379   
Ensembl ID ENSG00000163781   
PharmGKB ID PA134934073   

mRNA Information


mRNA ID ?NM_007027.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS46919.1



Protein Information


      
Protein IDNP_008958.2
Protein Nametopoisomerase (DNA) II binding protein 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1522  
Uniprot IDQ9NRR4
Ensembl Protein ID ENSP00000339845  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1138
SPhosphorylation492
SPhosphorylation554
SPhosphorylation853
TPhosphorylation1062
SPhosphorylation888;-
TPhosphorylation298;-
SPhosphorylation301;-
TPhosphorylation779
TPhosphorylation848
SPhosphorylation860
TPhosphorylation861
SPhosphorylation864
SPhosphorylation1002
SPhosphorylation1012
KAcetylation581
SPhosphorylation805
SPhosphorylation142
TPhosphorylation144
SPhosphorylation350
SPhosphorylation886
TPhosphorylation1221

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
207AKT11261NP_005154.2in vitro;in vivo17006541   
1869E2F11806NP_005216.1in vitro;in vivo126   978   281   457   643   000   000   000   
5371PML23NP_150241.2in vivo12773567   
5883RAD9A4788NP_004575.1in vivo11395493   
7155TOP2B537NP_001059.2in vitro;yeast 2-hybrid9461304   
7709ZBTB174968NP_003434.2in vitro;in vivo1   240   882   017   006   540   
10732TCFL55297NP_006593.2in vivo17006541   
51366UBR56436NP_056986.2in vitro;in vivo;yeast 2-hybrid11714696   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00027202-272  BRCT
cl00038202-272  BRCT superfamily
cd00027108-177  BRCT
cl00038108-177  BRCT superfamily
cd000271268-1337  BRCT
cl000381268-1337  BRCT superfamily
cd00027361-431  BRCT
cl00038361-431  BRCT superfamily
cd00027907-977  BRCT
cl00038907-977  BRCT superfamily
cd00027648-723  BRCT
cl00038648-723  BRCT superfamily
pfam12738203-266  PTCB-BRCT
pfam00533195-271  BRCT
smart00292198-271  BRCT
pfam12738649-720  PTCB-BRCT
pfam00533105-176  BRCT
smart00292356-431  BRCT
smart00292902-977  BRCT
pfam00533902-977  BRCT
pfam00533355-431  BRCT
smart00292105-176  BRCT
pfam00533643-723  BRCT
pfam005331261-1337  BRCT
smart00292643-723  BRCT
smart002921262-1337  BRCT
pfam12738109-171  PTCB-BRCT
pfam00533550-620  BRCT
cl00038550-620  BRCT superfamily
pfam12738362-426  PTCB-BRCT
pfam12738908-973  PTCB-BRCT
smart00292550-620  BRCT


Ontology Information


   
HPRD ID12136
Molecular ClassCell cycle control protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO