Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHD4 | 1108 | chromodomain helicase DNA binding protein 4  | 12 | Mi-2b, Mi2-BETA  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21447119    | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 28 gastric cancers (GCs) with high MSI (MSI-H), 45 GCs with low MSI (MSI-L)/stable MSI (MSS), 35 colorectal cancers (CRCs) with MSI-H and 45 CRCs with MSI-L/MSS. Stage : - | SSCP, immunohistochemistry | Loss of expression mutation | - | Frameshift mutation and loss of expression of CHD genes are common in GCs and CRCs with MSI-H. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, PHD-type |
| Description | The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]   |
| Chromosome | 12 |
| Location | 12p13 |
| Start | 6679248   |
| End | 6716551   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 37304   |
| OMIM ID | 603277    |
| HGNC ID | HGNC:1919    |
| Unigene ID | Hs.162233    |
| Ensembl ID | -    |
| PharmGKB ID | PA26455    |
mRNA Information
| mRNA ID | XM_006718962.1 |
|---|---|
| Exon | join(1..140,989..1166,4943..5064,5265..5480,5674..5792, 5910..6151,6387..6514,6771..6906,7084..7223,7428..7667, 9015..9218,9341..9546,11303..11434,12010..12106, 12790..12981,13824..14024,14212..14349,14623..14744, 14874..15047,15383..15524,15615..15746,15857..15974, 19018..19142,19491..19728,19881..20056,24062..24242, 24327..24413,24504..24592,24692..24825,25159..25303, 25626..25791,26052..26149,26267..26402,28523..28594, 28894..29031,29303..29411,29523..29655,34171..34369, 36408..36571,36747..37358)   | mRNA Sequence |    Download   Select all |
| Length | 6521   |
CDS Information
| Location | 219..5927 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS8552.1 |    
Protein Information
| Protein ID | XP_006719025.1 |
|---|---|
| Protein Name | chromodomain helicase DNA binding protein 4 |
| Molecular Wt. (Da) | 216750 |
| Protein Sequence |    Download   Select all |
| Length | 1902   |
| Uniprot ID | Q01974 |    
| Ensembl Protein ID | ENSP00000364860   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 100 |
| S | Phosphorylation | 1560 |
| S | Phosphorylation | 1562 |
| S | Phosphorylation | 1627 |
| S | Phosphorylation | 103 |
| S | Phosphorylation | 1535 |
| S | Phosphorylation | 1537 |
| S | Phosphorylation | 1602 |
| S | Phosphorylation | 1349;- |
| S | Phosphorylation | 425;- |
| S | Phosphorylation | 428;- |
| S | Phosphorylation | 1556;- |
| S | Phosphorylation | 1531;- |
| S | Phosphorylation | 322;- |
| S | Phosphorylation | 316;- |
| S | Phosphorylation | 325;- |
| Y | Phosphorylation | 326;- |
| S | Phosphorylation | 327;- |
| S | Phosphorylation | 328;- |
| Y | Phosphorylation | 329;- |
| S | Phosphorylation | 330;- |
| S | Phosphorylation | 325;- |
| S | Phosphorylation | 319;- |
| S | Phosphorylation | 334;- |
| S | Phosphorylation | 337;- |
| T | Phosphorylation | 333;- |
| T | Phosphorylation | 336;- |
| S | Phosphorylation | 329;- |
| S | Phosphorylation | 332;- |
| S | Phosphorylation | 332;- |
| S | Phosphorylation | 335;- |
| T | Phosphorylation | 43;- |
| T | Phosphorylation | 46;- |
| S | Phosphorylation | 528;- |
| S | Phosphorylation | 531;- |
| S | Phosphorylation | 305;- |
| S | Phosphorylation | 307;- |
| S | Phosphorylation | 308;- |
| S | Phosphorylation | 310;- |
| S | Phosphorylation | 306;- |
| S | Phosphorylation | 309;- |
| S | Phosphorylation | 512;- |
| S | Phosphorylation | 515;- |
| T | Phosphorylation | 514;- |
| T | Phosphorylation | 517;- |
| S | Phosphorylation | 102 |
| S | Phosphorylation | 105 |
| Y | Phosphorylation | 107 |
| S | Phosphorylation | 105 |
| S | Phosphorylation | 108 |
| Y | Phosphorylation | 110 |
| T | Phosphorylation | 526 |
| T | Phosphorylation | 529 |
| T | Phosphorylation | 1567 |
| T | Phosphorylation | 1542 |
| S | Phosphorylation | 1595 |
| S | Phosphorylation | 1601 |
| S | Phosphorylation | 1570 |
| S | Phosphorylation | 1576 |
| T | Phosphorylation | 1574 |
| T | Phosphorylation | 1578 |
| T | Phosphorylation | 1549 |
| T | Phosphorylation | 1553 |
| K | Acetylation | 984 |
| K | Acetylation | 987 |
| K | Acetylation | 881 |
| K | Acetylation | 884 |
| K | Acetylation | 1668 |
| K | Acetylation | 1643 |
| T | Phosphorylation | 1565 |
| T | Phosphorylation | 1540 |
| T | Phosphorylation | 1678 |
| T | Phosphorylation | 1653 |
| S | Phosphorylation | 1360 |
| S | Phosphorylation | 1364 |
| S | Phosphorylation | 1370 |
| S | Phosphorylation | 82 |
| S | Phosphorylation | 85 |
| S | Phosphorylation | 1395 |
| Y | Phosphorylation | 1088 |
| Y | Phosphorylation | 1091 |
| S | Phosphorylation | 582 |
| S | Phosphorylation | 585 |
| S | Phosphorylation | 83 |
| S | Phosphorylation | 86 |
| S | Phosphorylation | 41 |
| S | Phosphorylation | 44 |
| S | Phosphorylation | 1305 |
| S | Phosphorylation | 1308 |
| S | Phosphorylation | 1525 |
| S | Phosphorylation | 1500 |
| T | Phosphorylation | 1704 |
| T | Phosphorylation | 1679 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 545 |    ATR |    8369 |    NP_001175.2 |    in vitro;in vivo |    10545197    |
| 3065 |    HDAC1 |    3143 |    NP_004955.2 |    in vitro |    9804427    |
| 6597 |    SMARCA4 |    4459 |    NP_001122321.1 |    in vivo;yeast 2-hybrid |    14530259    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Viral carcinogenesis |    hsa05203 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15531 | 372-414  | PHD1_CHD_II |
| cl22851 | 372-414  | PHD_SF superfamily |
| cd15532 | 451-493  | PHD2_CHD_II |
| cl22851 | 451-493  | PHD_SF superfamily |
| cd00079 | 1064-1172  | HELICc |
| cl21455 | 1064-1172  | P-loop_NTPase superfamily |
| cd00046 | 746-904  | DEXDc |
| cl21455 | 746-904  | P-loop_NTPase superfamily |
| cd00024 | 619-674  | CHROMO |
| cl17459 | 619-674  | CHROMO superfamily |
| cd00024 | 540-577  | CHROMO |
| cl17459 | 540-577  | CHROMO superfamily |
| pfam08074 | 1724-1896  | CHDCT2 |
| cl06903 | 1724-1896  | CHDCT2 superfamily |
| pfam06461 | 1378-1523  | DUF1086 |
| cl05788 | 1378-1523  | DUF1086 superfamily |
| pfam08073 | 163-217  | CHDNT |
| cl06902 | 163-217  | CHDNT superfamily |
| smart00490 | 1080-1164  | HELICc |
| pfam00271 | 1084-1164  | Helicase_C |
| pfam06465 | 1302-1352  | DUF1087 |
| cl05792 | 1302-1352  | DUF1087 superfamily |
| cd15533 | 452-493  | PHD1_PHF12 |
| cd15523 | 451-493  | PHD_PHF21A |
| cd15532 | 372-414  | PHD2_CHD_II |
| cd15539 | 452-493  | PHD1_AIRE |
| cd15541 | 451-493  | PHD_TIF1_like |
| pfam00628 | 451-495  | PHD |
| cd15559 | 452-493  | PHD1_BPTF |
| cd15539 | 372-414  | PHD1_AIRE |
| cd15519 | 452-493  | PHD1_Lid2p_like |
| cd15523 | 372-414  | PHD_PHF21A |
| cd15531 | 451-493  | PHD1_CHD_II |
| pfam00628 | 372-414  | PHD |
| cd15515 | 452-493  | PHD1_KDM5A_like |
| cd15535 | 451-493  | PHD1_Rco1 |
| smart00249 | 451-493  | PHD |
| cd15524 | 451-493  | PHD_PHF21B |
| cd15567 | 451-493  | PHD4_NSD |
| cd15524 | 372-414  | PHD_PHF21B |
| cd15604 | 452-493  | PHD1_KDM5C_5D |
| cd15605 | 452-493  | PHD1_Lid_like |
| cd15519 | 373-414  | PHD1_Lid2p_like |
| smart00249 | 372-414  | PHD |
| cd15543 | 452-493  | PHD_RSF1 |
| cd15535 | 372-414  | PHD1_Rco1 |
| cd15625 | 450-493  | PHD_TIF1delta |
| cd15533 | 372-414  | PHD1_PHF12 |
| cd15627 | 452-493  | PHD_BAZ1A |
| cd15622 | 451-493  | PHD_TIF1alpha |
| cd15567 | 372-414  | PHD4_NSD |
| cd15541 | 372-414  | PHD_TIF1_like |
| cd15489 | 372-414  | PHD_SF |
| cd15489 | 451-493  | PHD_SF |
| cd15628 | 452-493  | PHD_BAZ1B |
| cd15545 | 372-414  | PHD_BAZ2A_like |
| cd15568 | 451-492  | PHD5_NSD |
| cd15537 | 372-414  | PHD_BS69 |
| cd15527 | 373-414  | PHD2_KAT6A_6B |
| cd15658 | 451-493  | PHD4_NSD3 |
| cd15602 | 452-493  | PHD1_KDM5A |
| cd15544 | 452-493  | PHD_BAZ1A_like |
| cd15627 | 373-414  | PHD_BAZ1A |
| cd15624 | 451-493  | PHD_TIF1gamma |
| cd15525 | 452-493  | PHD_UHRF1_2 |
| cd15559 | 372-414  | PHD1_BPTF |
| cd15617 | 452-493  | PHD_UHRF2 |
| cd15527 | 452-493  | PHD2_KAT6A_6B |
| cd15545 | 451-493  | PHD_BAZ2A_like |
| cd15568 | 372-413  | PHD5_NSD |
| cd15603 | 452-493  | PHD1_KDM5B |
| cd15661 | 372-412  | PHD5_NSD3 |
| smart00298 | 622-676  | CHROMO |
| cd15543 | 372-414  | PHD_RSF1 |
| cd15629 | 373-414  | PHD_BAZ2A |
| cd15656 | 451-493  | PHD4_NSD1 |
| cd15536 | 451-493  | PHD_PHRF1 |
| cd15622 | 372-414  | PHD_TIF1alpha |
| cd15513 | 452-493  | PHD5_KMT2C_like |
| cd15544 | 373-414  | PHD_BAZ1A_like |
| cd15538 | 451-493  | PHD_PRKCBP1 |
| cd15628 | 373-414  | PHD_BAZ1B |
| cd15538 | 372-414  | PHD_PRKCBP1 |
| cd15625 | 369-414  | PHD_TIF1delta |
| cd15657 | 451-493  | PHD4_NSD2 |
| pfam00385 | 624-674  | Chromo |
| cd15536 | 372-414  | PHD_PHRF1 |
| cd15530 | 372-414  | PHD2_d4 |
| cd15616 | 452-493  | PHD_UHRF1 |
| cd15513 | 373-414  | PHD5_KMT2C_like |
| cd15594 | 373-414  | PHD2_KMT2C |
| cd15624 | 372-414  | PHD_TIF1gamma |
| cd15510 | 452-493  | PHD2_KMT2C_like |
| cd15595 | 373-414  | PHD2_KMT2D |
| cd15629 | 452-493  | PHD_BAZ2A |
| cd11725 | 359-420  | ADDz_Dnmt3 |
| cd15595 | 452-493  | PHD2_KMT2D |
| cd15660 | 372-412  | PHD5_NSD2 |
| cd15626 | 452-493  | PHD_SP110_140 |
| cd15623 | 452-493  | PHD_TIF1beta |
| cd15656 | 372-414  | PHD4_NSD1 |
| cd15497 | 372-414  | PHD1_Snt2p_like |
| cd15661 | 451-491  | PHD5_NSD3 |
| cd15605 | 373-414  | PHD1_Lid_like |
| cd15604 | 373-414  | PHD1_KDM5C_5D |
| cd15504 | 372-414  | PHD_PRHA_like |
| cd15515 | 373-414  | PHD1_KDM5A_like |
| cd15658 | 372-414  | PHD4_NSD3 |
| cd15499 | 373-416  | PHD1_MTF2_PHF19_like |
| cd15594 | 452-493  | PHD2_KMT2C |
| cd15626 | 373-414  | PHD_SP110_140 |
| cd15497 | 452-493  | PHD1_Snt2p_like |
| cd15603 | 373-414  | PHD1_KDM5B |
| cd15617 | 373-414  | PHD_UHRF2 |
| cd15563 | 373-414  | PHD3_PHF14 |
| cd15602 | 373-417  | PHD1_KDM5A |
| cd15510 | 373-414  | PHD2_KMT2C_like |
| cd15525 | 373-414  | PHD_UHRF1_2 |
| cd15534 | 451-492  | PHD2_PHF12_Rco1 |
| cd15623 | 373-414  | PHD_TIF1beta |
| cd15530 | 452-493  | PHD2_d4 |
| smart00298 | 540-579  | CHROMO |
| cd15562 | 451-493  | PHD2_PHF14 |
| cd15537 | 451-493  | PHD_BS69 |
| cd15529 | 452-493  | PHD2_PHF10 |
| cd15504 | 451-493  | PHD_PRHA_like |
| cd15630 | 451-493  | PHD_BAZ2B |
| cd15566 | 451-492  | PHD3_NSD |
| cd15630 | 372-414  | PHD_BAZ2B |
| cd15502 | 451-493  | PHD_Phf1p_Phf2p_like |
| cd15657 | 372-414  | PHD4_NSD2 |
| cd15502 | 373-414  | PHD_Phf1p_Phf2p_like |
| cd15616 | 373-414  | PHD_UHRF1 |
| cd15562 | 373-414  | PHD2_PHF14 |
| cd11726 | 439-471  | ADDz_ATRX |
| cd15659 | 373-412  | PHD5_NSD1 |
| cd15659 | 452-491  | PHD5_NSD1 |
| cd15509 | 373-414  | PHD1_KMT2C_like |
| cd15578 | 373-415  | PHD1_MTF2 |
| cd15534 | 373-412  | PHD2_PHF12_Rco1 |
| cd15507 | 451-493  | PHD2_KMT2A_like |
| cd15529 | 373-414  | PHD2_PHF10 |
| cd15660 | 452-491  | PHD5_NSD2 |
| cd15590 | 451-493  | PHD2_KMT2A |
| cd15499 | 452-495  | PHD1_MTF2_PHF19_like |
| cd15509 | 451-493  | PHD1_KMT2C_like |
| cd15572 | 451-493  | PHD_BRPF |
| cd15591 | 451-493  | PHD2_KMT2B |
| cd11726 | 363-416  | ADDz_ATRX |
| cd15648 | 373-414  | PHD1_NSD1_2 |
| cd15566 | 372-413  | PHD3_NSD |
| cd15578 | 452-493  | PHD1_MTF2 |
| cd15563 | 452-493  | PHD3_PHF14 |
| cd15506 | 452-493  | PHD1_KMT2A_like |
| cd15501 | 452-493  | PHD_Int12 |
| cd15522 | 372-414  | PHD_TAF3 |
| cd15585 | 372-414  | PHD_ING3 |
| cd15505 | 372-414  | PHD_ING |
| cd04718 | 471-494  | BAH_plant_2 |
| cl02608 | 471-494  | BAH superfamily |
| cd15648 | 452-494  | PHD1_NSD1_2 |
| cd04718 | 392-417  | BAH_plant_2 |
| cl02608 | 392-417  | BAH superfamily |
| cd15585 | 459-493  | PHD_ING3 |
| cd15677 | 452-493  | PHD_BRPF2 |
| cd15676 | 452-493  | PHD_BRPF1 |
| pfam14962 | 1583-1658  | AIF-MLS |
| cl20843 | 1583-1658  | AIF-MLS superfamily |
| cd15522 | 451-493  | PHD_TAF3 |
| cd15677 | 376-414  | PHD_BRPF2 |
| cd15492 | 451-493  | PHD_BRPF_JADE_like |
| cd15492 | 373-414  | PHD_BRPF_JADE_like |
| cd15685 | 372-417  | PHD_ING5 |
| cd15507 | 372-414  | PHD2_KMT2A_like |
| cd15679 | 373-414  | PHD_JADE1 |
| cd11672 | 440-493  | ADDz |
| cd15573 | 373-414  | PHD_JADE |
| cd15678 | 451-493  | PHD_BRPF3 |
| cd15590 | 372-414  | PHD2_KMT2A |
| cd15680 | 452-493  | PHD_JADE2 |
| cd15586 | 372-414  | PHD_ING4_5 |
| cd15681 | 373-414  | PHD_JADE3 |
| cd11672 | 363-414  | ADDz |
| pfam13831 | 459-493  | PHD_2 |
| cd15584 | 372-414  | PHD_ING1_2 |
| cd15572 | 376-414  | PHD_BRPF |
| cd15556 | 452-493  | PHD_MMD1_like |
| pfam04851 | 869-904  | ResIII |
| pfam00176 | 729-1025  | SNF2_N |
| PLN03142 | 724-1281  | PLN03142 |
| COG0553 | 711-1222  | HepA |
| smart00487 | 720-928  | DEXDc |
| PRK04914 | 866-973  | PRK04914 |
| COG5034 | 364-417  | TNG2 |
| pfam06614 | 1531-1649  | Neuromodulin |
| COG1061 | 724-1176  | SSL2 |
| COG0513 | 1068-1164  | SrmB |
| COG1111 | 1064-1232  | MPH1 |
| PRK14950 | 1532-1658  | PRK14950 |
| PRK13108 | 1522-1649  | PRK13108 |
| PRK10811 | 1518-1658  | rne |
Ontology Information
| HPRD ID | 1218 |    
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
