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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CHD4 1108 chromodomain helicase DNA binding protein 4  12Mi-2b, Mi2-BETA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21447119   2011Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 28 gastric cancers (GCs) with high MSI (MSI-H), 45 GCs with low MSI (MSI-L)/stable MSI (MSS), 35 colorectal cancers (CRCs) with MSI-H and 45 CRCs with MSI-L/MSS.

Stage : -

SSCP, immunohistochemistryLoss of expression mutation-Frameshift mutation and loss of expression of CHD genes are common in GCs and CRCs with MSI-H.


Gene Details



NC_000012.11 (6679248..6716551, complement)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]  
Chromosome 12
Location 12p13
Start 6679248  
End 6716551  
Strand -  
Gene Sequence

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Length 37304  
OMIM ID 603277   
HGNC ID HGNC:1919   
Unigene ID Hs.162233   
Ensembl ID -   
PharmGKB ID PA26455   

mRNA Information


mRNA ID XM_006718962.1
Exon join(1..140,989..1166,4943..5064,5265..5480,5674..5792, 5910..6151,6387..6514,6771..6906,7084..7223,7428..7667, 9015..9218,9341..9546,11303..11434,12010..12106, 12790..12981,13824..14024,14212..14349,14623..14744, 14874..15047,15383..15524,15615..15746,15857..15974, 19018..19142,19491..19728,19881..20056,24062..24242, 24327..24413,24504..24592,24692..24825,25159..25303, 25626..25791,26052..26149,26267..26402,28523..28594, 28894..29031,29303..29411,29523..29655,34171..34369, 36408..36571,36747..37358)  
mRNA Sequence

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Length 6521  



CDS Information


   
Location219..5927
CDS Sequence

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CCDS ID CCDS8552.1



Protein Information


      
Protein IDXP_006719025.1
Protein Namechromodomain helicase DNA binding protein 4
Molecular Wt. (Da)216750
Protein Sequence

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Length 1902  
Uniprot IDQ01974
Ensembl Protein ID ENSP00000364860  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation100
SPhosphorylation1560
SPhosphorylation1562
SPhosphorylation1627
SPhosphorylation103
SPhosphorylation1535
SPhosphorylation1537
SPhosphorylation1602
SPhosphorylation1349;-
SPhosphorylation425;-
SPhosphorylation428;-
SPhosphorylation1556;-
SPhosphorylation1531;-
SPhosphorylation322;-
SPhosphorylation316;-
SPhosphorylation325;-
YPhosphorylation326;-
SPhosphorylation327;-
SPhosphorylation328;-
YPhosphorylation329;-
SPhosphorylation330;-
SPhosphorylation325;-
SPhosphorylation319;-
SPhosphorylation334;-
SPhosphorylation337;-
TPhosphorylation333;-
TPhosphorylation336;-
SPhosphorylation329;-
SPhosphorylation332;-
SPhosphorylation332;-
SPhosphorylation335;-
TPhosphorylation43;-
TPhosphorylation46;-
SPhosphorylation528;-
SPhosphorylation531;-
SPhosphorylation305;-
SPhosphorylation307;-
SPhosphorylation308;-
SPhosphorylation310;-
SPhosphorylation306;-
SPhosphorylation309;-
SPhosphorylation512;-
SPhosphorylation515;-
TPhosphorylation514;-
TPhosphorylation517;-
SPhosphorylation102
SPhosphorylation105
YPhosphorylation107
SPhosphorylation105
SPhosphorylation108
YPhosphorylation110
TPhosphorylation526
TPhosphorylation529
TPhosphorylation1567
TPhosphorylation1542
SPhosphorylation1595
SPhosphorylation1601
SPhosphorylation1570
SPhosphorylation1576
TPhosphorylation1574
TPhosphorylation1578
TPhosphorylation1549
TPhosphorylation1553
KAcetylation984
KAcetylation987
KAcetylation881
KAcetylation884
KAcetylation1668
KAcetylation1643
TPhosphorylation1565
TPhosphorylation1540
TPhosphorylation1678
TPhosphorylation1653
SPhosphorylation1360
SPhosphorylation1364
SPhosphorylation1370
SPhosphorylation82
SPhosphorylation85
SPhosphorylation1395
YPhosphorylation1088
YPhosphorylation1091
SPhosphorylation582
SPhosphorylation585
SPhosphorylation83
SPhosphorylation86
SPhosphorylation41
SPhosphorylation44
SPhosphorylation1305
SPhosphorylation1308
SPhosphorylation1525
SPhosphorylation1500
TPhosphorylation1704
TPhosphorylation1679

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
545ATR8369NP_001175.2in vitro;in vivo10545197   
3065HDAC13143NP_004955.2in vitro9804427   
6597SMARCA44459NP_001122321.1in vivo;yeast 2-hybrid14530259   


Pathway Information


      
Pathway Name Pathway ID
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15531372-414  PHD1_CHD_II
cl22851372-414  PHD_SF superfamily
cd15532451-493  PHD2_CHD_II
cl22851451-493  PHD_SF superfamily
cd000791064-1172  HELICc
cl214551064-1172  P-loop_NTPase superfamily
cd00046746-904  DEXDc
cl21455746-904  P-loop_NTPase superfamily
cd00024619-674  CHROMO
cl17459619-674  CHROMO superfamily
cd00024540-577  CHROMO
cl17459540-577  CHROMO superfamily
pfam080741724-1896  CHDCT2
cl069031724-1896  CHDCT2 superfamily
pfam064611378-1523  DUF1086
cl057881378-1523  DUF1086 superfamily
pfam08073163-217  CHDNT
cl06902163-217  CHDNT superfamily
smart004901080-1164  HELICc
pfam002711084-1164  Helicase_C
pfam064651302-1352  DUF1087
cl057921302-1352  DUF1087 superfamily
cd15533452-493  PHD1_PHF12
cd15523451-493  PHD_PHF21A
cd15532372-414  PHD2_CHD_II
cd15539452-493  PHD1_AIRE
cd15541451-493  PHD_TIF1_like
pfam00628451-495  PHD
cd15559452-493  PHD1_BPTF
cd15539372-414  PHD1_AIRE
cd15519452-493  PHD1_Lid2p_like
cd15523372-414  PHD_PHF21A
cd15531451-493  PHD1_CHD_II
pfam00628372-414  PHD
cd15515452-493  PHD1_KDM5A_like
cd15535451-493  PHD1_Rco1
smart00249451-493  PHD
cd15524451-493  PHD_PHF21B
cd15567451-493  PHD4_NSD
cd15524372-414  PHD_PHF21B
cd15604452-493  PHD1_KDM5C_5D
cd15605452-493  PHD1_Lid_like
cd15519373-414  PHD1_Lid2p_like
smart00249372-414  PHD
cd15543452-493  PHD_RSF1
cd15535372-414  PHD1_Rco1
cd15625450-493  PHD_TIF1delta
cd15533372-414  PHD1_PHF12
cd15627452-493  PHD_BAZ1A
cd15622451-493  PHD_TIF1alpha
cd15567372-414  PHD4_NSD
cd15541372-414  PHD_TIF1_like
cd15489372-414  PHD_SF
cd15489451-493  PHD_SF
cd15628452-493  PHD_BAZ1B
cd15545372-414  PHD_BAZ2A_like
cd15568451-492  PHD5_NSD
cd15537372-414  PHD_BS69
cd15527373-414  PHD2_KAT6A_6B
cd15658451-493  PHD4_NSD3
cd15602452-493  PHD1_KDM5A
cd15544452-493  PHD_BAZ1A_like
cd15627373-414  PHD_BAZ1A
cd15624451-493  PHD_TIF1gamma
cd15525452-493  PHD_UHRF1_2
cd15559372-414  PHD1_BPTF
cd15617452-493  PHD_UHRF2
cd15527452-493  PHD2_KAT6A_6B
cd15545451-493  PHD_BAZ2A_like
cd15568372-413  PHD5_NSD
cd15603452-493  PHD1_KDM5B
cd15661372-412  PHD5_NSD3
smart00298622-676  CHROMO
cd15543372-414  PHD_RSF1
cd15629373-414  PHD_BAZ2A
cd15656451-493  PHD4_NSD1
cd15536451-493  PHD_PHRF1
cd15622372-414  PHD_TIF1alpha
cd15513452-493  PHD5_KMT2C_like
cd15544373-414  PHD_BAZ1A_like
cd15538451-493  PHD_PRKCBP1
cd15628373-414  PHD_BAZ1B
cd15538372-414  PHD_PRKCBP1
cd15625369-414  PHD_TIF1delta
cd15657451-493  PHD4_NSD2
pfam00385624-674  Chromo
cd15536372-414  PHD_PHRF1
cd15530372-414  PHD2_d4
cd15616452-493  PHD_UHRF1
cd15513373-414  PHD5_KMT2C_like
cd15594373-414  PHD2_KMT2C
cd15624372-414  PHD_TIF1gamma
cd15510452-493  PHD2_KMT2C_like
cd15595373-414  PHD2_KMT2D
cd15629452-493  PHD_BAZ2A
cd11725359-420  ADDz_Dnmt3
cd15595452-493  PHD2_KMT2D
cd15660372-412  PHD5_NSD2
cd15626452-493  PHD_SP110_140
cd15623452-493  PHD_TIF1beta
cd15656372-414  PHD4_NSD1
cd15497372-414  PHD1_Snt2p_like
cd15661451-491  PHD5_NSD3
cd15605373-414  PHD1_Lid_like
cd15604373-414  PHD1_KDM5C_5D
cd15504372-414  PHD_PRHA_like
cd15515373-414  PHD1_KDM5A_like
cd15658372-414  PHD4_NSD3
cd15499373-416  PHD1_MTF2_PHF19_like
cd15594452-493  PHD2_KMT2C
cd15626373-414  PHD_SP110_140
cd15497452-493  PHD1_Snt2p_like
cd15603373-414  PHD1_KDM5B
cd15617373-414  PHD_UHRF2
cd15563373-414  PHD3_PHF14
cd15602373-417  PHD1_KDM5A
cd15510373-414  PHD2_KMT2C_like
cd15525373-414  PHD_UHRF1_2
cd15534451-492  PHD2_PHF12_Rco1
cd15623373-414  PHD_TIF1beta
cd15530452-493  PHD2_d4
smart00298540-579  CHROMO
cd15562451-493  PHD2_PHF14
cd15537451-493  PHD_BS69
cd15529452-493  PHD2_PHF10
cd15504451-493  PHD_PRHA_like
cd15630451-493  PHD_BAZ2B
cd15566451-492  PHD3_NSD
cd15630372-414  PHD_BAZ2B
cd15502451-493  PHD_Phf1p_Phf2p_like
cd15657372-414  PHD4_NSD2
cd15502373-414  PHD_Phf1p_Phf2p_like
cd15616373-414  PHD_UHRF1
cd15562373-414  PHD2_PHF14
cd11726439-471  ADDz_ATRX
cd15659373-412  PHD5_NSD1
cd15659452-491  PHD5_NSD1
cd15509373-414  PHD1_KMT2C_like
cd15578373-415  PHD1_MTF2
cd15534373-412  PHD2_PHF12_Rco1
cd15507451-493  PHD2_KMT2A_like
cd15529373-414  PHD2_PHF10
cd15660452-491  PHD5_NSD2
cd15590451-493  PHD2_KMT2A
cd15499452-495  PHD1_MTF2_PHF19_like
cd15509451-493  PHD1_KMT2C_like
cd15572451-493  PHD_BRPF
cd15591451-493  PHD2_KMT2B
cd11726363-416  ADDz_ATRX
cd15648373-414  PHD1_NSD1_2
cd15566372-413  PHD3_NSD
cd15578452-493  PHD1_MTF2
cd15563452-493  PHD3_PHF14
cd15506452-493  PHD1_KMT2A_like
cd15501452-493  PHD_Int12
cd15522372-414  PHD_TAF3
cd15585372-414  PHD_ING3
cd15505372-414  PHD_ING
cd04718471-494  BAH_plant_2
cl02608471-494  BAH superfamily
cd15648452-494  PHD1_NSD1_2
cd04718392-417  BAH_plant_2
cl02608392-417  BAH superfamily
cd15585459-493  PHD_ING3
cd15677452-493  PHD_BRPF2
cd15676452-493  PHD_BRPF1
pfam149621583-1658  AIF-MLS
cl208431583-1658  AIF-MLS superfamily
cd15522451-493  PHD_TAF3
cd15677376-414  PHD_BRPF2
cd15492451-493  PHD_BRPF_JADE_like
cd15492373-414  PHD_BRPF_JADE_like
cd15685372-417  PHD_ING5
cd15507372-414  PHD2_KMT2A_like
cd15679373-414  PHD_JADE1
cd11672440-493  ADDz
cd15573373-414  PHD_JADE
cd15678451-493  PHD_BRPF3
cd15590372-414  PHD2_KMT2A
cd15680452-493  PHD_JADE2
cd15586372-414  PHD_ING4_5
cd15681373-414  PHD_JADE3
cd11672363-414  ADDz
pfam13831459-493  PHD_2
cd15584372-414  PHD_ING1_2
cd15572376-414  PHD_BRPF
cd15556452-493  PHD_MMD1_like
pfam04851869-904  ResIII
pfam00176729-1025  SNF2_N
PLN03142724-1281  PLN03142
COG0553711-1222  HepA
smart00487720-928  DEXDc
PRK04914866-973  PRK04914
COG5034364-417  TNG2
pfam066141531-1649  Neuromodulin
COG1061724-1176  SSL2
COG05131068-1164  SrmB
COG11111064-1232  MPH1
PRK149501532-1658  PRK14950
PRK131081522-1649  PRK13108
PRK108111518-1658  rne


Ontology Information


   
HPRD ID1218
Molecular ClassDNA binding protein
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO