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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22948784 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 143 Stage : - | Real-time PCR, Western blotting, immunohistochemistry | Up-regulation | - | ESM-1 is significantly overexpressed, which is regulated by HIF-1 in CRC patients, and can be used as a potential biomarker and a therapeutic target for CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | 5 |
| Location | 5q11 |
| Start | 54977867 |
| End | 54985586 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7720 |
| OMIM ID | 601521 |
| HGNC ID | HGNC:3466 |
| Unigene ID | Hs.129944 |
| Ensembl ID | ENSG00000164283 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001135604.1 |
|---|---|
| Exon | join(1..370,6152..7720) | mRNA Sequence | Download Select all |
| Length | 1939 |
CDS Information
| Location | join(70..370,6152..6255) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47206.1 |
Protein Information
| Protein ID | NP_001129076.1 |
|---|---|
| Protein Name | endothelial cell-specific molecule 1 |
| Molecular Wt. (Da) | 12540 |
| Protein Sequence | Download Select all |
| Length | 134 |
| Uniprot ID | Q14624 |
| Ensembl Protein ID | ENSP00000266041 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3689 | ITGB2 | 2506 | NP_000202.2 | in vivo | 11544294 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00121 | 26-100 | IB |
| cl02472 | 26-100 | IGFBP superfamily |
| pfam00219 | 28-83 | IGFBP |
Ontology Information
| HPRD ID | 993 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.