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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DIDO1 11083 death inducer-obliterator 1  20DIO1, dJ885L7.8, FLJ11265, KIAA0333, DIO-1, BYE1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22711543   2012Cell line : -

Source : VU University medical center, Amsterdam, The Netherlands.

Sample Type : Tissue microarrays

No. of Sample : 82 colon adenomas and 82 CRCs

Stage : -

Immunohistochemistry ,genome-wide (microarray-based) DNA and mRNA profilingUp-regulation-DIDO1 and RBM39 protein expression was quite strong in the majority of tumors irrespective of 20q DNA copy number status.


Gene Details



NC_000020.10 (61509090..61569304, complement)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]  
Chromosome 20
Location 20q13.33
Start 61509090  
End 61569304  
Strand -  
Gene Sequence

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Length 60215  
OMIM ID 604140   
HGNC ID HGNC:2680   
Unigene ID Hs.517172   
Ensembl ID ENSG00000101191   
PharmGKB ID PA27147   

mRNA Information


mRNA ID ?NM_001193369.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS13508.2



Protein Information


      
Protein IDNP_001180298.1
Protein Namedeath inducer-obliterator 1
Molecular Wt. (Da)0
Protein Sequence

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Length 2240  
Uniprot IDQ9UHD2
Ensembl Protein ID ENSP00000329967  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation152;-
SPhosphorylation154;-
TPhosphorylation151;-
SPhosphorylation152;-
SPhosphorylation154;-
TPhosphorylation151;-
SPhosphorylation152;-
SPhosphorylation154;-
TPhosphorylation151;-
SPhosphorylation152;-
SPhosphorylation154;-
TPhosphorylation151;-
SPhosphorylation156;-
SPhosphorylation156;-
SPhosphorylation156;-
SPhosphorylation156;-
TPhosphorylation1719;-
SPhosphorylation898;-
SPhosphorylation898;-
SPhosphorylation1040;-
SPhosphorylation1040;-
SPhosphorylation809;-
SPhosphorylation811;-
SPhosphorylation809;-
SPhosphorylation811;-
SPhosphorylation817;-
SPhosphorylation817;-
SPhosphorylation677;-
SPhosphorylation677;-
TPhosphorylation1310;-
SPhosphorylation1456;-
TPhosphorylation1256;-
SPhosphorylation1260;-
SPhosphorylation805
SPhosphorylation805
SPhosphorylation1017
SPhosphorylation1017
SPhosphorylation1019
SPhosphorylation1019
SPhosphorylation1030
TPhosphorylation1035
SPhosphorylation1030
TPhosphorylation1035
SPhosphorylation1248
SPhosphorylation1254
TPhosphorylation1255
TPhosphorylation1469
SPhosphorylation1712
SPhosphorylation1714
SPhosphorylation1312
SPhosphorylation650
SPhosphorylation650
SPhosphorylation1471
SPhosphorylation609
SPhosphorylation609
SPhosphorylation88
SPhosphorylation114
SPhosphorylation88
SPhosphorylation114
SPhosphorylation88
SPhosphorylation114
SPhosphorylation88
SPhosphorylation114
SPhosphorylation111
SPhosphorylation117
SPhosphorylation111
SPhosphorylation117
SPhosphorylation111
SPhosphorylation117
SPhosphorylation111
SPhosphorylation117
SPhosphorylation1582
SPhosphorylation523
SPhosphorylation523
SPhosphorylation523
SPhosphorylation523
SPhosphorylation1327
SPhosphorylation1331
SPhosphorylation1522
SPhosphorylation1974
SPhosphorylation2192
SPhosphorylation2194

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15639266-319  PHD_DIDO1_like
cl22851266-319  PHD_SF superfamily
smart00510672-773  TFS2M
cl02637672-773  TFIIS_M superfamily
pfam07500666-776  TFIIS_M
cd15552270-319  PHD_PHF3_like
pfam077441057-1163  SPOC
cl066711057-1163  SPOC superfamily
cd15560270-319  PHD2_3_BPTF
cd15554270-319  PHD_PHF2_like
cd15553270-319  PHD_Cfp1
cd15638272-319  PHD_PHF3
cd16039270-319  PHD_SPP1
cd15640270-322  PHD_KDM7
pfam00628270-320  PHD
smart00249270-319  PHD
cd15642269-323  PHD_PHF8
cd15550271-319  PHD_MLL5
cd15489270-319  PHD_SF
cd15641270-319  PHD_PHF2
cd15518270-319  PHD_Ecm5p_Lid2p_like
cd15505270-319  PHD_ING
cd15606270-319  PHD2_KDM5A
cd15517283-319  PHD_TCF19_like
cd15610285-319  PHD3_KDM5A_like
cd15522270-319  PHD_TAF3
cd15613278-320  PHD_AL_plant
cd15542270-319  PHD_UBR7
cd15556271-319  PHD_MMD1_like
cd15585270-319  PHD_ING3
cd15520271-319  PHD3_Lid2p_like
cd15570271-319  PHD_Bye1p_SIZ1_like
cd15634271-319  PHD_PHF20
cd15516270-319  PHD2_KDM5A_like
cd15549271-319  PHD_PHF20_like
cd15506282-319  PHD1_KMT2A_like
cd15584270-319  PHD_ING1_2
pfam049591735-1826  ARS2
cl202831735-1826  ARS2 superfamily
cd15529271-319  PHD2_PHF10
cd15633271-320  PHD_PHF20L1
cd15615283-319  PHD_ARID4_like
cd15547271-319  PHD_SHPRH
cd15686273-320  PHD3_KDM5A
cd15548271-319  PHD_ASH1L
cd15587270-320  PHD_Yng1p_like
cd15511257-319  PHD3_KMT2C
cd15687273-319  PHD3_KDM5B
cd15546271-319  PHD_PHF13_like
cd15632271-319  PHD_PHF13
cd15503270-297  PHD2_MTF2_PHF19_like
cd15543271-319  PHD_RSF1
pfam041021472-1525  SlyX
cl010901472-1525  SlyX superfamily
TIGR01385651-767  TFSII
PHA032471525-2054  PHA03247
pfam096061725-2055  Med15
COG5034160-302  TNG2
TIGR016222125-2230  SF-CC1
pfam097701811-2082  PAT1
PHA032471523-1829  PHA03247
pfam097701723-2015  PAT1
PRK077641582-1799  PRK07764
pfam031571729-2064  Glutenin_hmw
PRK077641601-1798  PRK07764
PHA033071604-1942  PHA03307
PRK077641539-1888  PRK07764
pfam096061544-1950  Med15
PHA033071640-1933  PHA03307
PHA032471716-2066  PHA03247
PRK123231522-1752  PRK12323
TIGR016281888-2038  PABP-1234
TIGR016422124-2226  U2AF_lg
PRK123231459-1699  PRK12323
PRK077641687-2061  PRK07764
pfam074151735-1827  Herpes_LMP2
PRK126782037-2214  PRK12678
TIGR016222124-2236  SF-CC1
PHA03247773-1044  PHA03247
PRK077641637-1858  PRK07764
pfam031571537-2077  Glutenin_hmw
TIGR016422125-2235  U2AF_lg
PHA032471679-2063  PHA03247
pfam152401738-1834  Pro-rich
PHA033071593-2007  PHA03307
PHA033781703-1834  PHA03378
PLN03209860-1041  PLN03209
PLN03209860-1022  PLN03209
pfam152401738-1920  Pro-rich


Ontology Information


   
HPRD ID12531
Molecular ClassUnclassified
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of cell cycle (GO:0000074); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO