Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADAMTS5 | 11096 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 21 | ADMP-2, ADAMTS11 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21298349 | 2011 | Cell line : - Source : Samsung Medical Center (Seoul, Korea) Sample Type : CRC tumor and normal tissues No. of Sample : 22 Stage : - | Pyrosequencing,Methylation profiling based on bead-chip arrays | Methylation | - | Validated ten CpG sites that were hypermethylated (ADHFE1, BOLL, SLC6A15, ADAMTS5, TFPI2, EYA4, NPY, TWIST1, LAMA1, GAS7) and 2 CpG sites showing hypomethylation (MAEL, SFT2D3) in CRC compared to the normal mucosa. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidases with thrombospondin type 1 motif |
| Description | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
| Chromosome | 21 |
| Location | 21q21.3 |
| Start | 28290231 |
| End | 28339439 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 49209 |
| OMIM ID | 605007 |
| HGNC ID | HGNC:221 |
| Unigene ID | Hs.58324 |
| Ensembl ID | ENSG00000154736 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_008969.2 |
|---|---|
| Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 930 |
| Uniprot ID | Q9UI15 |
| Ensembl Protein ID | ENSP00000273368 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4322 | MMP13 | 2522 | NP_002418.1 | in vitro | 11032846 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04273 | 269-473 | ZnMc_ADAMTS_like |
| cl00064 | 269-473 | ZnMc superfamily |
| pfam05986 | 732-852 | ADAM_spacer1 |
| cl20316 | 732-852 | ADAM_spacer1 superfamily |
| cd04267 | 269-465 | ZnMc_ADAM_like |
| cd04269 | 269-474 | ZnMc_adamalysin_II_like |
| pfam01562 | 67-175 | Pep_M12B_propep |
| cl03265 | 67-175 | Pep_M12B_propep superfamily |
| smart00209 | 570-622 | TSP1 |
| cl15278 | 570-622 | TSP_1 superfamily |
| cd04272 | 269-464 | ZnMc_salivary_gland_MPs |
| pfam13582 | 311-421 | Reprolysin_3 |
| cd00203 | 360-464 | ZnMc |
| pfam13688 | 268-421 | Reprolysin_5 |
| pfam13583 | 271-460 | Reprolysin_4 |
| pfam13574 | 356-465 | Reprolysin_2 |
| pfam00090 | 573-621 | TSP_1 |
| smart00209 | 879-930 | TSP1 |
| cl15278 | 879-930 | TSP_1 superfamily |
| cd04278 | 406-420 | ZnMc_MMP |
| smart00608 | 486-556 | ACR |
| cl15456 | 486-556 | ADAM_CR superfamily |
| cd04277 | 406-420 | ZnMc_serralysin_like |
| pfam01421 | 269-476 | Reprolysin |
| pfam00413 | 406-424 | Peptidase_M10 |
| smart00235 | 407-424 | ZnMc |
Ontology Information
| HPRD ID | 6405 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Peptidase activity (GO:0008233) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.